Increased operational capabilities of a dialysis system

Patent metadata

Field	Value
Publication number	US-12569601-B2
Application number	US-202117224256-A
Country	US
Kind code	B2
Filing date	Apr 7, 2021
Priority date	Apr 7, 2021
Publication date	Mar 10, 2026
Grant date	Mar 10, 2026

Abstract

The disclosure relates to systems and methods for increasing the functional capabilities of a sorbent-based dialysis system. The systems and methods allow for the mode of operation of the dialysis system to be switched between single pass mode and a sorbent based multi-pass mode by controlling an amount of water added to the dialysate between 0% to 100% of the dialysate flow rate.

First claim

What is claimed is:

1 . A system comprising:
a fluid flow path comprising:
a dialyzer outlet fluidly connectable to a dialyzer;
a first valve fluidly connecting the fluid flow path to a drain line;
a sorbent cartridge positioned downstream of the first valve;
a second valve fluidly connecting the fluid flow path to a water source; and
a dialyzer inlet downstream of the sorbent cartridge; and
a control system,
wherein the control system is programmed to control a mode of operating the fluid flow path between a first mode of operation and a second mode of operation by controlling a water addition rate using the first valve and the second valve,
wherein one of the first mode of operation and the second mode of operation is a hybrid mode,
wherein, in the hybrid mode, at least a first portion of a fluid in the fluid flow path is diverted to the drain line and while the at least first portion of the fluid is diverted to the drain line, at least a second portion of the fluid simultaneously remains in the fluid flow path; and

wherein the control system is programmed to temporarily switch the mode of operation during a dialysis session based on a detected condition of the fluid flow path, until the detected condition is resolved.

2 . The system of claim 1 , wherein the first mode of operation is a first water addition rate and the second mode of operation is a second water addition rate.

3 . The system of claim 1 , wherein the control system is programmed to switch from the first mode of operation to the second mode of operation at a predetermined time during the dialysis session.

4 . The system of claim 3 , wherein the control system is programmed to determine the predetermined time based on one or more patient parameters.

5 . The system of claim 3 , wherein the control system is programmed to determine the predetermined time based on a sorbent cartridge capacity.

6 . The system of claim 3 , wherein the predetermined time is based on a patient weight.

7 . The system of claim 3 , wherein the predetermined time is based on at least one of a patient BUN level, a bicarbonate prescription, blood flow rate, dialysate flow rate, dialyzer koA, and patient volume.

8 . The system of claim 1 , further comprising at least one sensor between the dialyzer outlet and the first valve.

9 . The system of claim 8 , wherein the control system is programmed to determine a percent clearance for a dialysis session based on the at least one sensor.

10 . The system of claim 9 , wherein the control system is programmed to switch the mode of operation at a predetermined percent clearance.

11 . The system of claim 8 , wherein the sensor measures either creatinine or urea.

12 . The system of claim 8 , wherein the control system is programmed to determine if a sorbent cartridge capacity has been reached based on the at least one sensor.

13 . The system of claim 12 , wherein the control system is programmed to switch from the hybrid mode to a single pass mode if the sorbent cartridge capacity has been reached.

14 . The system of claim 1 , wherein the detected condition is a concentration of one or more solutes in the dialysate due to release of the ions from a sorbent cartridge.

15 . The system of claim 1 , wherein the detected condition is ammonia detected by an ammonia sensor positioned downstream of a sorbent cartridge.

16 . The system of claim 1 , further comprising:
a sensor positioned fluidly between the dialyzer inlet and the sorbent cartridge configured to detect if at least one capacity of the sorbent cartridge has been reached.

17 . The system of claim 1 , wherein the first valve is a proportioning valve configured to divert between 0% to 100% of the flow through the first valve to the drain line based on the mode of operating the fluid flow path.

18 . A system comprising:
a fluid flow path fluidly connected to a dialyzer comprising:
i) a first valve fluidly connecting the fluid flow path to a drain line; and
ii) a second valve fluidly connecting the fluid flow path to a water source; and
a control system,
wherein the control system is programmed to control a mode of operating the fluid flow path between a plurality of modes of operation by controlling a water addition rate,
wherein a first mode of the plurality of modes of operation is a single pass mode and a second mode of the plurality of modes of operation is a hybrid mode,
wherein, in the single pass mode, all of a fluid that passes through the first valve is diverted to the drain line,
wherein, in the hybrid mode, at least a first portion of a fluid in the fluid flow path is diverted to the drain line and while the at least first portion of the fluid is diverted to the drain line, at least a second portion of the fluid simultaneously remains in the fluid flow path, and water is pumped into the fluid flow path from the water source; and

wherein the control system is programmed to switch the mode of operation during a dialysis session to the single pass mode when a concentration of solutes in the fluid is detected and is programmed to switch the mode of operation back to the hybrid mode when the concentration of solutes in the fluid reaches a threshold level.

Assignees

• Mozarc Medical Us Llc

Inventors

• Patil Kaustubh R
• Dutta Sukalyan
• Hobot Christopher M
• Pudil Bryant J

Classifications

• A61M1/1611

  Weight of the patient · CPC title

• A61M2205/3334

  Measuring or controlling the flow rate · CPC title

• A61M2205/3327

  Measuring · CPC title

• A61M1/1647 Primary

  with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser · CPC title

• A61M1/1607

  before use, i.e. upstream of dialyser · CPC title