Method for preparing poly (thioctic acid)-copper coating on surface of cardiovascular stent material

Patent metadata

Field	Value
Publication number	US-12569598-B2
Application number	US-202318515201-A
Country	US
Kind code	B2
Filing date	Nov 20, 2023
Priority date	Nov 29, 2022
Publication date	Mar 10, 2026
Grant date	Mar 10, 2026

Abstract

A method for preparing a poly(thioctic acid)-copper coating (poly(TA-Cu)) on a surface of a cardiovascular stent material includes: grinding a cardiovascular stent material with sandpaper until the surface of the cardiovascular stent material is flat and smooth, rinsing the cardiovascular stent material with deionized water and anhydrous ethanol in sequence, and drying the cardiovascular stent material to obtain a pre-treated cardiovascular stent material; dissolving thioctic acid in an alcoholic solvent, adding anhydrous copper chloride to a mixed solution of thioctic acid and the alcoholic solvent, stirring the mixed solution, to yield a precursor solution; treating the pre-treated cardiovascular stent material with the precursor solution, and drying, thus forming a poly(thioctic acid)-copper coating on the surface of the pre-treated cardiovascular stent material. The concentration of thioctic acid in the alcoholic solvent is 0.1-0.3 g/mL, and the molar ratio of anhydrous copper chloride to thioctic acid monomer is 1:100-5000.

First claim

What is claimed is:

1 . A method for preparing a poly(thioctic acid)-copper coating (poly(TA-Cu)) on a surface of a cardiovascular stent material, comprising:
grinding a cardiovascular stent material with sandpaper until a surface of the cardiovascular stent material is flat and smooth, rinsing the cardiovascular stent material with deionized water and anhydrous ethanol in sequence, and drying the cardiovascular stent material to obtain a pre-treated cardiovascular stent material; dissolving thioctic acid in an alcoholic solvent, adding anhydrous copper chloride to a mixed solution of thioctic acid and the alcoholic solvent, stirring the mixed solution, to yield a precursor solution; treating the pre-treated cardiovascular stent material with the precursor solution, and drying, thus forming a poly(thioctic acid)-copper coating on the surface of the pre-treated cardiovascular stent material;
wherein:
a concentration of thioctic acid in the alcoholic solvent is 0.1-0.3 g/mL, and a molar ratio of anhydrous copper chloride to thioctic acid monomer is between 1:100 and 1:5000.

2 . The method of claim 1 , wherein the cardiovascular stent material is magnesium alloy, zinc alloy, iron alloy, 316L stainless steel, nickel titanium alloy, cobalt chromium alloy, or polylactic acid.

3 . The method of claim 1 , wherein the alcoholic solvent is anhydrous methanol or anhydrous ethanol.

4 . The method of claim 1 , wherein the cardiovascular stent material is treated with the precursor solution through dip coating, spin coating, or spray coating, to form the poly(thioctic acid)-copper coating on the surface of the pre-treated cardiovascular stent material.

5 . The method of claim 1 , further comprising disposing a magnesium fluoride conversion layer on the pre-treated cardiovascular stent material, which comprises submerging the pre-treated cardiovascular stent material into a hydrofluoric acid solution for 40-50 hours at 20-40° C., cleaning and drying a resulting product, to achieve the magnesium fluoride conversion layer on the pre-treated cardiovascular stent material; wherein the hydrofluoric acid solution has a concentration of 35-40 wt. %, and the poly(thioctic acid)-copper coating is formed on the magnesium fluoride conversion layer.

Assignees

• Univ Zhengzhou

Inventors

• Guan Shaokang
• Zhang Zhaoqi
• Li Jingan
• Zhu Shijie
• Wang Liguo
• Tong Peiduo
• Wang Yahui

Classifications

• A61L2420/02

  Methods for coating medical devices · CPC title

• A61L2420/06

  Coatings containing a mixture of two or more compounds · CPC title

• A61L31/10

  Macromolecular materials · CPC title

• A61L31/16

  Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} · CPC title

• A61L31/022

  Metals or alloys · CPC title