Nanoparticles for medical and diagnostic applications

Patent metadata

Field	Value
Publication number	US-12569450-B2
Application number	US-202017776481-A
Country	US
Kind code	B2
Filing date	Nov 9, 2020
Priority date	Nov 13, 2019
Publication date	Mar 10, 2026
Grant date	Mar 10, 2026

Abstract

The present disclosure provides nanoparticles comprising methyl palmitate and at least one serumglobular protein and uses thereof.

First claim

The invention claimed is:

1 . A composition comprising nanoparticles comprising methyl palmitate and albumin, wherein the nanoparticles comprise methyl palmitate and albumin in a weight ratio (w/w) between 5:1 and 2:1.

2 . The composition according to claim 1 , wherein the average diameter size of the nanoparticles is comprised between 180 nm and 240 nm.

3 . A method for producing the nanoparticles according to claim 1 , comprising the following steps:
preparing a first solution comprising methyl palmitate, preparing a second solution comprising albumin, adding the second solution to the first solution to obtain a third solution comprising methyl palmitate and albumin in a weight ratio (w/w) comprised between 2:2.5 and 2:20, mixing the third solution thereby allowing the production of nanoparticles in the solution, and separating the nanoparticles.

4 . The method according to claim 3 , wherein the separating step is carried out by centrifugation of the solution containing the nanoparticles.

5 . The method according to claim 3 , wherein the separating step is carried out at a temperature comprised between 4° C. and 9° C.

6 . A kit comprising the composition according to claim 1 and at least one active principle or at least one imaging agent, said at least one active principle or said at least one imaging agent being contained in at least one Secondary Administered Nanoparticle,
for separate and sequential use in inhibiting the phagocytic activity of the macrophages and in increasing the bioavailability of said active principle and/or said imaging agent in a mammal.

Assignees

• Fondazione St Italiano Tecnologia

Inventors

• Palomba Roberto
• Decuzzi Paolo

Classifications

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• B82Y5/00

  Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K9/5192

  Processes · CPC title

• A61K9/5123 Primary

  Organic compounds, e.g. fats, sugars · CPC title