Apparatus and method for augmented interpretation of magnetic resonance and ultrasound shear wave elastography for monitoring liver fibrosis

Patent metadata

Field	Value
Publication number	US-12569186-B2
Application number	US-202218273127-A
Country	US
Kind code	B2
Filing date	Jan 25, 2022
Priority date	Jan 27, 2021
Publication date	Mar 10, 2026
Grant date	Mar 10, 2026

Abstract

A method and system ( 100 ) for augmented interpretation of shear wave elastography between first and second imaging modalities comprises performing an elastography measurement via a second imaging modality ( 20 ), different from a first imaging modality ( 10 ), to obtain at least one second imaging modality elastography value ( 32, 60 ) of a region of interest ( 33 ). At least one corresponding first imaging modality elastography value ( 36, 38, 62 ) is predicted based on the obtained second imaging modality elastography value. A graphical user interface or smart report dashboard ( 50 ) is generated that shows (i) a fibrosis level ( 521 ) of the region of interest, wherein the fibrosis level is determined as a function of (i)(a) the at least one second imaging modality elastography value ( 32 ) and/or (i)(b) the predicted at least one corresponding first imaging modality elastography value ( 36, 38 ).

First claim

What is claimed is:

1 . A method for augmented interpretation of shear wave elastography between first and second imaging modalities, the method comprising:
performing an elastography measurement via a second imaging modality, different from a first imaging modality, to obtain at least one second imaging modality elastography value of a region of interest; predicting, via a processor, at least one corresponding first imaging modality elastography value based on the obtained second imaging modality elastography value; and generating, via the processor and a display, a smart report dashboard that includes (i) a fibrosis level of the region of interest, wherein the fibrosis level is determined as a function of (i) (a) the at least one second imaging modality elastography value and/or (i) (b) the predicted at least one corresponding first imaging modality elastography value.

2 . The method of claim 1 , wherein the second imaging modality is selected between (i) magnetic resonance shear wave elastography (MRE) and (ii) ultrasound shear wave elastography (UE), and wherein the first imaging modality comprises the non-selected imaging modality of the second imaging modality.

3 . The method of claim 1 , wherein elastography values obtained via the second imaging modality are not comparable with elastography values obtained via the first imaging modality.

4 . The method of claim 1 , wherein the at least one second imaging modality elastography value and the at least one corresponding predicted first imaging modality elastography value each comprise one or more of (i) a stiffness map and (ii) a stiffness value in units of kPa.

5 . The method of claim 1 , further comprising:
predicting, via the processor, a confidence score related to the at least one second imaging modality elastography value, wherein the predicted confidence score comprises a highest percentage of confidence among percentages of confidence in each of multiple fibrosis levels F0-F4 based on the second imaging modality elastography measurement; and selecting, via the processor, a predicted fibrosis level based on the fibrosis level having the highest percentage of confidence.

6 . The method of claim 1 , wherein the smart report dashboard further includes (ii) a baseline fibrosis level of the region of interest, the baseline fibrosis level having been determined based on a baseline elastography measurement performed via the first imaging modality to obtain at least one baseline first imaging modality elastography value of the region of interest, the baseline elastography measurement having been performed prior to the elastography measurement via the second imaging modality.

7 . The method of claim 6 , wherein the smart report dashboard further includes (iii) a percentage change in elastography value between (iii)(a) the predicted at least one first imaging modality elastography value based on the obtained at least one second imaging modality elastography value and (iii)(b) the at least one baseline first imaging modality elastography value.

8 . The method of claim 7 , wherein the smart report dashboard further includes (iv) the at least one second imaging modality elastography value of the region of interest, (v) the predicted at least one corresponding first imaging modality elastography value of the region of interest, and (vi) a confidence score related to the at least one second imaging modality elastography value, wherein the confidence score is a percentage between 0 and 100 percent and is representative of a level of confidence in the fibrosis level that is based on the at least one second imaging modality elastography value.

9 . The method of claim 1 , wherein predicting the at least one corresponding first imaging modality elastography value comprises initiating a deep learning-based algorithm to predict the at least one corresponding first imaging modality elastography value, wherein the deep learning-based algorithm comprises one selected from the group consisting of a generative adversarial network (GAN) and a convolutional neural network (CNN).

10 . The method of claim 9 , further comprising:
determining, via the processor and a second deep learning-based algorithm, a confidence score related to the at least one second imaging modality elastography value, and wherein determining of the confidence score is automatically activated simultaneously with the initiating of the deep learning-based algorithm, the confidence score further for providing a real-time classification of, or a level of confidence in, the fibrosis level that is based on the at least one second imaging modality elastography value.

11 . A system for augmented interpretation of shear wave elastography between first and second imaging modalities, comprising:
an input for receiving imaging data pertaining to an elastography measurement obtained from a second imaging modality; a controller configured to perform an elastography measurement via the second imaging modality, different from a first imaging modality, to obtain at least one second imaging modality elastography value of a region of interest, predict at least one corresponding first imaging modality elastography value based on the obtained second imaging modality elastography value, and generate a smart report dashboard that includes (i) a fibrosis level of the region of interest, wherein the fibrosis level is determined as a function of (i)(a) the at least one second imaging modality elastography value and/or (i)(b) the predicted at least one corresponding first imaging modality elastography value; and a display in communication with the controller to display the smart report dashboard.

12 . The system of claim 11 , wherein the second imaging modality is selected between (i) magnetic resonance shear wave elastography (MRE) and (ii) ultrasound shear wave elastography (UE), and wherein the first imaging modality comprises the non-selected imaging modality of the second imaging modality.

13 . The system of claim 11 , wherein elastography values obtained via the second imaging modality are not comparable with elastography values obtained via the first imaging modality.

14 . The system of claim 11 , wherein the at least one second imaging modality elastography value and the at least one corresponding predicted first imaging modality elastography value each comprise one or more of (i) a stiffness map and (ii) a stiffness value in units of kPa.

15 . The system of claim 11 , wherein the controller is further configured to:
predict a confidence score related to the at least one second imaging modality elastography value, wherein the predicted confidence score comprises a highest percentage of confidence among percentages of confidence in each of multiple fibrosis levels F0-F4 based on the second imaging modality elastography measurement; and select a predicted fibrosis level based on the fibrosis level having the highest percentage of confidence.

16 . The system of claim 11 , wherein the smart report dashboard further includes (ii) a baseline fibrosis level of the region of interest, the baseline fibrosis level having been determined based on a baseline elastography measurement performed via the first imaging modality to obtain at least one baseline first imaging modality elastography value of the region of interest, the baseline elastography measurement having been performed prior to the elastography measurement via the second imaging modality.

17 . The system of claim 16 , wherein the smart report dashboard further includes (iii) a percentage change in elastograp

Assignees

• Koninklijke Philips Nv

Inventors

• Sadeghi Seyedali
• Errico Claudia
• Kruecker Jochen
• Xie Hua

Classifications

• A61B8/5223

  for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012) · CPC title

• A61B8/465

  adapted to display user selection data, e.g. icons or menus · CPC title

• A61B8/463

  characterised by displaying multiple images or images and diagnostic data on one display · CPC title

• A61B5/7267

  involving training the classification device · CPC title

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title