Preventing cytokine release syndrome

Patent metadata

Field	Value
Publication number	US-12564622-B2
Application number	US-202218078645-A
Country	US
Kind code	B2
Filing date	Dec 9, 2022
Priority date	Dec 27, 2017
Publication date	Mar 3, 2026
Grant date	Mar 3, 2026

Abstract

Provided herein are methods and materials for preventing cytokine release syndrome (CRS). For example, methods and materials for using one or more catecholamine inhibitors to prevent a mammal from developing CRS are provided.

First claim

What is claimed is:

1 . A method for treating a mammal having cytokine release syndrome (CRS), wherein said method comprises administering a catecholamine inhibitor to said mammal.

2 . The method of claim 1 , wherein said catecholamine is selected from the group consisting of epinephrine, norepinephrine, dopamine, and combinations thereof.

3 . The method of claim 2 , wherein said catecholamine is epinephrine.

4 . The method of claim 1 , wherein said mammal is a human.

5 . The method of claim 1 , wherein said catecholamine inhibitor comprises a tyrosine hydroxylase inhibitor, and wherein said tyrosine hydroxylase inhibitor is metyrosine.

6 . The method of claim 1 , wherein said catecholamine inhibitor comprises a natriuretic peptide selected from the group consisting of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and dendroaspis natriuretic peptide (DNP).

7 . The method of claim 6 , wherein said natriuretic peptide is ANP, and wherein said ANP comprises SEQ ID NO:1.

8 . The method of claim 1 , wherein said catecholamine inhibitor comprises an agent that can accelerate catecholamine degradation, and wherein said agent that can accelerate catecholamine degradation is a monoamine oxidase A activator or a catechol-O-methyltransferase (COMT) activator.

9 . The method of claim 1 , wherein said catecholamine inhibitor comprises an agent that can block catecholamine release, wherein said agent that can block catecholamine release is gabapentin.

10 . The method of claim 1 , wherein said catecholamine inhibitor comprises an agent that can block the α1 adrenergic receptor, wherein said agent that can block the α1 adrenergic receptor is prazosin.

11 . The method of claim 1 , wherein said catecholamine inhibitor comprises both a natriuretic peptide and a hydroxylase inhibitor, wherein said natriuretic peptide is atrial natriuretic peptide (ANP) and wherein said tyrosine hydroxylase inhibitor is metyrosine.

12 . The method of claim 1 , wherein said CRS is associated with sepsis.

13 . The method of claim 1 , wherein said CRS is associated with an immunotherapy.

14 . The method of claim 13 , wherein said immunotherapy is selected from the group consisting of orthoclone OKT3, muromonab-CD3, rituximab, alemtuzumab, tosituzumab, CP-870,893, LO-CD2a/BTI-322, TGN1412, tisagenlecleucel, axicabtagene ciloleucel, bi-specific T-cell engagers (BiTEs), adoptive T-cell therapy, dendritic cell therapy, interferon therapy, interleukin therapy, bacterial therapy, and viral therapy.

15 . The method of claim 13 , wherein said immunotherapy is a cancer immunotherapy.

Assignees

• Univ Johns Hopkins

Inventors

• Vogelstein Bert
• Kinzler Kenneth W
• Papadopoulos Nickolas
• Zhou Shibin
• Staedtke Verena
• Bai Renyuan
• Riggins Gregory J

Classifications

• A61K31/517

  ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine · CPC title

• A61K31/198

  Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00) · CPC title

• A61K31/137

  Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone} · CPC title

• A61P37/06

  Immunosuppressants, e.g. drugs for graft rejection · CPC title

• A61K31/195

  having an amino group · CPC title