Device and method for producing a patch which has a plurality of microstructures

Patent metadata

Field	Value
Publication number	US-12558525-B2
Application number	US-202117917347-A
Country	US
Kind code	B2
Filing date	Mar 29, 2021
Priority date	Apr 7, 2020
Publication date	Feb 24, 2026
Grant date	Feb 24, 2026

Abstract

A device for producing a patch which includes a plurality of microstructures has at least one die. The die is used to produce a microstructure and has a plurality of depressions for this purpose. Additionally, a support layer, which is provided with an adhesive layer, is provided. In a preferred embodiment, it is possible to move the microstructure formed in the die in the direction of the support layer using a lifting device such that said microstructure adheres to the face of the support layer, which is provided with the adhesive layer. For example, by carrying out a corresponding method multiple times, multiple microstructures can be provided on the support layer adjacently to one another. Optionally, multiple dies can also be provided so that multiple microstructures can be simultaneously arranged on the support layer.

First claim

The invention claimed is:

1 . A device for producing a patch which comprises multiple microstructures, the device comprising:
at least one die which comprises a plurality of depressions for producing a microstructure; a support layer which comprises an adhesive layer; and a lifting device comprising one plunger per each die of the at least one die such that the lifting device has at least one plunger that is displaceable in the direction of the support layer, wherein each plunger comprises an upper surface which rests on a lower surface of each plunger's respective die of the at least one die, wherein the lifting device is configured to move each plunger of the at least one plunger against each respective die of the at least one die so as to perform a relative movement between the at least one die and the support layer such that the microstructure arranged in the at least one die adhere to the support layer, and wherein a displacement device for horizontally displacing the support layer relative to the at least one die is provided, such that multiple microstructures are arranged side-by-side on the support layer, and/or multiple dies are provided side-by-side.

2 . The device according to claim 1 , wherein the lifting device is formed such that multiple microstructures can be moved simultaneously.

3 . The device according to claim 1 , wherein the at least one plunger is surrounded in each case, at least in part, by a receiving device, and wherein the receiving device supports the at least one die.

4 . The device according to claim 3 , wherein the at least one plunger can be displaced in the receiving device, and the at least one die is produced from resilient material.

5 . The device according to claim 3 , wherein the receiving device comprises a hollow cylinder which is connected to a base element.

6 . The device according to claim 5 , wherein two or more plungers are provided, and wherein the two or more plungers are interconnected by means of the base element.

7 . A method for producing a patch comprising multiple microstructures using a device for producing a patch which comprises multiple microstructures, the device comprising:
at least one die which comprises a plurality of depressions for producing a microstructure; a support layer which comprises an adhesive layer; and a lifting device for performing a relative movement between the at least one die and the support layer such that the microstructure arranged in the at least one die adhere to the support layer, wherein a displacement device for in particular horizontally displacing the support layer relative to the at least one die is provided, such that multiple microstructures are arranged side-by-side on the support layer, and/or multiple dies are provided side-by-side wherein the method comprises the steps of: metering a formulation into depressions of at least one die; moving the at least one die relative to a support layer comprising an adhesive layer, such that the microstructure arranged in the at least one die adheres to the support layer; displacing the at least one die relative to the support layer and subsequently moving the at least one die relative to the support layer comprising the adhesive layer, such that the microstructure arranged in the at least one die adheres to the support layer next to the microstructure(s) already adhering thereto; pushing at least one plunger into at least one receiving device, wherein, in each case, the receiving device is formed as a hollow cylinder, such that an upper surface of the at least one plunger rests on a lower surface of each respective die of the at least one die and/or simultaneously moving multiple dies relative to the support layer comprising the adhesive layer.

8 . The method according to claim 7 , wherein the at least one die is moved relative to the support layer, in that each respective plunger of the least one plunger is moved further, and wherein the at least one die undergoes elastic deformation.

Assignees

• Lts Lohmann Therapie Systeme Ag

Inventors

• Henke Stefan
• Trommer Hagen
• Scherr Sebastian

Classifications

• A61M2207/10

  Device therefor · CPC title

• A61M2037/0053

  Methods for producing microneedles · CPC title

• A61M2037/0046

  Solid microneedles · CPC title

• A61M37/0015 Primary

  by using microneedles · CPC title