Sealing systems for a reservoir of an on-body injector

Patent metadata

Field	Value
Publication number	US-12558482-B1
Application number	US-202217935321-A
Country	US
Kind code	B1
Filing date	Sep 26, 2022
Priority date	May 4, 2021
Publication date	Feb 24, 2026
Grant date	Feb 24, 2026

Abstract

An on-body injector includes a drug reservoir having an outlet. First and second pistons may be positioned within the reservoir, with the second piston first being moved to open the outlet, followed by the first piston being moved to convey a drug from the reservoir via the outlet. The reservoir may instead include a cover, with a valve positioned between the outlet and the cover. The valve is rotated to place a channel of the valve in fluid communication with a through-hole of the cover, allowing flow from the reservoir via the outlet. The reservoir may instead include a valve movable from a condition in which it deforms the outlet, preventing flow through the outlet, to a condition allowing flow. The reservoir may instead include a seal that is deformed by an increase in pressure within the reservoir, with the deformed seal being open to allow flow through the outlet.

First claim

The invention claimed is:

1 . An on-body injector comprising:
a housing; an adhesive pad associated with a lower surface of the housing and configured to be removably attached to a human body surface; a drug reservoir positioned within the housing and including a deformable outlet; a valve associated with the outlet and comprising first and second jaws configured to receive at least a portion of the outlet therebetween; a release mechanism associated to the valve and comprising a filament formed of a shape memory alloy; a needle fluidically connected to the outlet of the drug reservoir; and a controller configured to control the on-body injector to execute a drug delivery routine, wherein the filament is configured to contract in order to move at least a portion of at least one of the first and second jaws with respect to the other one of the first and second jaws so as to move the valve from a first condition in which the first and second laws engage and deform the outlet so as to prevent fluid flow from the drug reservoir via the outlet to a second condition in which the valve allows fluid flow from the drug reservoir via the outlet.

2 . The on-body injector of claim 1 , wherein
the controller is configured to cause an electrical current to flow through the filament, and the filament is configured to contract when said electrical current flows through the filament, thereby moving said at least a portion of said at least one of the first and second jaws with respect to the other one of the first and second jaws.

3 . The on-body injector of claim 1 , wherein the controller is configured to execute a drug delivery routine for a drug comprising pegfilgrastim.

4 . The on-body injector of claim 1 , wherein a portion of the drug reservoir is defined by a sidewall formed of a generally rigid material.

5 . The on-body injector of claim 4 , wherein
the drug reservoir includes an end associated with the sidewall, and the outlet is associated with said end of the drug reservoir.

6 . The on-body injector of claim 4 , further comprising a piston configured to form a seal with the sidewall and to move through the drug reservoir toward said end of the drug reservoir during the drug delivery routine.

7 . The on-body injector of claim 1 , wherein the drug reservoir is formed of a generally flexible or deformable material.

8 . The on-body injector of claim 7 , wherein an interior of the housing is pressurized so as to apply a force to the drug reservoir.

9 . The on-body injector of claim 7 , wherein the drug reservoir is configured to be deformed by physical contact.

10 . The on-body injector of claim 9 , further comprising two surfaces, wherein
at least a portion of the drug reservoir is positioned between said two surfaces, and at least one of said surfaces is configured to be moved toward the other surface so as to apply a compressive force to the portion of the drug reservoir positioned between said surfaces.

11 . The on-body injector of claim 10 , wherein each surface is configured to move toward the other surface so as to apply said compressive force to the portion of the drug reservoir positioned between said surfaces.

12 . The on-body injector of claim 10 , wherein each surface is configured as a flat plate.

13 . The on-body injector of claim 9 , wherein the controller is configured to cause said physical contact to be applied to the drug reservoir when the valve is in the first condition.

14 . The on-body injector of claim 9 , wherein the controller is configured to cause said physical contact to not be applied to the drug reservoir when the valve is in the first condition.

15 . The on-body injector of claim 1 , wherein
the outlet is configured as a tube, and the valve is configured to press a portion of the tube against an opposing portion of the tube when the valve is in the first condition.

16 . The on-body injector of claim 1 , wherein the outlet is formed of an elastomeric material.

17 . The on-body injector of claim 1 , wherein the outlet is formed of a polyvinyl chloride material.

18 . The on-body injector of claim 1 , wherein the release mechanism is configured to move the valve between said first and second conditions.

19 . The on-body injector of claim 1 , wherein the filament is secured to one of the first and second jaws.

Assignees

• Fresenius Kabi Deutschland Gmbh

Inventors

• Schiff David R
• West Sharon D
• Zerweck Jason

Classifications

• A61M5/14248 Primary

  of the skin patch type · CPC title

• A61M5/16881 Primary

  Regulating valves (on-off valves, e.g. clamps A61M39/28) · CPC title

• A61M2005/14252

  with needle insertion means · CPC title

• A61M5/1454 Primary

  spring-actuated, e.g. by a clockwork · CPC title