Ultrahigh ductility, novel Mg—Li based alloys for biomedical applications

Patent metadata

Field	Value
Publication number	US-12558454-B2
Application number	US-202418402953-A
Country	US
Kind code	B2
Filing date	Jan 3, 2024
Priority date	Dec 12, 2014
Publication date	Feb 24, 2026
Grant date	Feb 24, 2026

Abstract

The invention includes compositions including magnesium-lithium alloys containing various alloying elements for medical implant devices. The devices are constructed of the compositions or have applied thereto a coating formed therefrom. Within the structure of the magnesium-lithium alloy, there is a co-existence of alpha and beta phases. The invention also includes methods of preparing the magnesium-lithium-based alloys and articles, such as medical implant devices, for use in medical applications, including orthopedic, dental, craniofacial and cardiovascular surgeries.

First claim

The invention claimed is:

1 . A method for preparing a coated medical implant device, comprising:
obtaining a substrate structured for implanting into a body; forming a coating composition comprising: forming an alloy, comprising:
I alloying about 9.0% by weight of lithium, 0.96% by weight of zinc, and 0.01% by weight of aluminum, and a remainder of magnesium based on the total weight of the alloy, or
II alloying about 8.99% by weight of lithium, 0.87% by weight zinc, and 1.07% by weight aluminum, and a remainder of magnesium based on the total weight of the alloy, or
III alloying about 6.11% by weight of lithium, 0.92% by weight zinc, and 0.04% by weight aluminum, and a remainder of magnesium based on the total weight of the alloy,
wherein the alloy of I, II or III is structured to exhibit a co-existence of alpha and beta phases, and
wherein the alloy of I, II or III exhibits one or more of improved ductility and elasticity; and
applying the coating composition onto a surface of the substrate to form a coating thereon.

2 . The method of claim 1 , wherein the alloying step further comprises adding to I, II or III one or more alloying elements selected from the group consisting of iron, zirconium, manganese, calcium, yttrium, rare earth elements, strontium, copper, silver, silicon, sodium, potassium, and cerium.

3 . The method of claim 1 , further comprising adding an active agent to the coating composition.

4 . The method of claim 1 , further comprising using the coated medical implant device in orthopedic, dental, craniofacial and cardiovascular surgeries.

5 . The method of claim 1 , wherein the coated medical implant device releases lithium ions as a therapeutic drug eluting device.

6 . The method of claim 1 , wherein the alloying step comprises:
high energy mechanical alloying of I, II or III alloy compositions; followed by uniaxial or isostatic compaction; and followed by sintering.

Assignees

• Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• Kumta Prashant N
• Wu Jingyao
• Velikokhatnyi Oleg

Classifications

• A61L31/082

  Inorganic materials · CPC title

• A61L31/088

  Other specific inorganic materials not covered by A61L31/084 or A61L31/086 · CPC title

• A61L27/306

  Other specific inorganic materials not covered by A61L27/303 - A61L27/32 · CPC title

• A61L27/047 Primary

  Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06 · CPC title

• A61L31/022

  Metals or alloys · CPC title