Bacterial dna gyrase inhibitors and methods of use thereof
US-2023364057-A1 · Nov 16, 2023 · US
Bacterial DNA gyrase inhibitors and methods of use thereof
US12558366B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12558366-B2 |
| Application number | US-202418921816-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 21, 2024 |
| Priority date | Sep 13, 2021 |
| Publication date | Feb 24, 2026 |
| Grant date | Feb 24, 2026 |
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- Title
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Abstract
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The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
First claim
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We claim: 1 . A method for inhibiting a DNA gyrase of E. coli comprising contacting the DNA gyrase with a compound selected from compounds 25, 46, 48, 117, 119, 120, 121, 123, 124, and 125 and measuring the DNA gyrase activity.
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condensed with carbocyclic rings, e.g. methantheline {(cannabinoids A61K31/658)} · CPC title
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)} · CPC title
Antibacterial agents · CPC title
Purines, e.g. adenine · CPC title
having five-membered rings · CPC title
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- What does patent US12558366B2 cover?
- The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
- Who is the assignee on this patent?
- Leng Fenfei, Alfonso Eddy, Deng Zifang, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification A61K31/185. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).