2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide and derivatives as inhibitor of clock:bmal1 interaction for the treatment of circadian rhythm diseases and disorders

Patent metadata

Field	Value
Publication number	US-12558342-B2
Application number	US-201917785970-A
Country	US
Kind code	B2
Filing date	Dec 16, 2019
Priority date	Dec 16, 2019
Publication date	Feb 24, 2026
Grant date	Feb 24, 2026

Abstract

A 2-[2-({12,12-dimethyl-4-oxo-6-phenyl-3,11-dioxatricyclo[8.4.0.0,2,7]tetradeca-1,5,7,9-tetraen-8-yl}oxy)acetamido]benzamide compound and related derivatives, as well as the use thereof in the preparation of a medicament for treatment and/or prevention of diseases or disorders associated with the circadian rhythm are provided. The compound of the invention is a CLOCK-binding small molecule and also an inhibitor of CLOCK:BMAL1 interaction, and is therefore useful, as pharmaceutical agent, especially in the treatment and/or prevention of disorders associated with the circadian rhythm.

First claim

What is claimed is:

1 . A method for a treatment of a disease or a disorder associated with circadian rhythm in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound having the following formula or a pharmaceutically acceptable salt of the compound:

wherein the disease or the disorder is a sleep disorder.

2 . The method according to claim 1 , wherein the compound has an inhibition of CLOCK:BMAL1 interaction.

3 . The method according to claim 1 , wherein the sleep disorder is a circadian rhythm sleep disorder selected from the group consisting of a shift work sleep disorder, a jet lag syndrome, an advanced sleep phase syndrome, a non-24-hour sleep-wake syndrome, an irregular sleep-wake rhythm, and a delayed sleep phase syndrome.

Assignees

• Univ Koc

Inventors

• Kavakli Ibrahim Halil
• Turkay Metin
• Doruk Yagmur Umay
• Yarparvar Darya

Classifications

• A61K31/352 Primary

  condensed with carbocyclic rings, e.g. methantheline  {(cannabinoids A61K31/658)} · CPC title

• A61P25/00

  Drugs for disorders of the nervous system · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P25/20

  Hypnotics; Sedatives · CPC title

• A61K31/353 Primary

  3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title