Methods of detecting and mapping spinal cord epidurally-evoked potentials

Patent metadata

Field	Value
Publication number	US-12558018-B2
Application number	US-201716466236-A
Country	US
Kind code	B2
Filing date	Dec 12, 2017
Priority date	Dec 12, 2016
Publication date	Feb 24, 2026
Grant date	Feb 24, 2026

Abstract

Embodiments of the present invention relate to a novel approach to automatically detect the occurrence of evoked potentials, quantify the attributes of the signal and visualize the effect across a high number of spinal cord epidural stimulation parameters. This new method is designed to automate the current process for performing this task that has been accomplished manually by data analysts through observation of the raw EMG signals, which is laborious and time-consuming as well as being prone to human errors. The proposed method provides fast and accurate framework for activation detection and visualization of the results within five main algorithms.

First claim

What is claimed is:

1 . A method for detection and characterization of evoked potentials in muscles, comprising:
recording electrical signals from a plurality of a patient's muscles; dividing the electrical signals into sequential segments; reducing the noise of the electrical signals, wherein reducing the noise comprises converting each electrical signal into a 2-D image and applying an image smoothing method to the 2-D image to reduce signal noise; calculating, for each segment, a highest statistical difference Si between the electrical signal in that segment and background noise; calculating a dynamic threshold h; and detecting an evoked potential in the plurality of the patient's muscles if Si>h in at least 50% of the segments; and wherein detecting the evoked potential in the plurality of the patient's muscles includes localizing the evoked potential in one muscle in the plurality of the patient's muscles.

2 . The method of claim 1 , further comprising delivering a plurality of epidural stimulations to the patient's spinal cord at a first stimulation voltage, each of the plurality of epidural stimulations separated by a time interval.

3 . The method of claim 2 , wherein the delivering and the recording occur concurrently.

4 . The method of claim 2 , wherein each of the sequential segments has a duration equal to the time interval.

5 . The method of claim 2 , wherein each segment temporally overlaps with delivery of one of the plurality of epidural stimulations.

6 . The method of claim 1 , wherein the electrical signals are electromyography signals.

7 . The method of claim 1 , wherein Si is determined by

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.

8 . The method of claim 1 , wherein h is determined by
h=S max +σ S i .

9 . The method of claim 1 , further comprising delivering a plurality of epidural stimulations to the patient's spinal cord at a first stimulation voltage, followed by delivering a plurality of epidural stimulations to the patient's spinal cord at a second stimulation voltage, wherein the second stimulation voltage is unequal to the first stimulation voltage.

10 . The method of claim 9 , wherein the second stimulation voltage is higher than the first stimulation voltage.

11 . The method of claim 1 , further comprising extracting at least one feature of the evoked potential.

12 . The method of claim 11 , wherein the feature is one of a peak-to-peak interval, a min-max interval, an activation latency, and an integrated EMG.

13 . The method of claim 11 , further comprising displaying the at least one feature in a visually perceptible format.

14 . The method of claim 13 , wherein the visually perceptible format is a colormap image.

15 . The method of claim 1 , wherein the image smoothing method is a Gaussian Markov Random Field model.

16 . A method for detection and characterization of evoked potentials in muscles, comprising:
delivering a plurality of epidural stimulations to a patient at a stimulation voltage, each of the plurality of epidural stimulations separated by a time interval; recording electrical signals from a plurality of the patient's muscles, wherein the recording is concurrent with the delivering; dividing the electrical signals into sequential segments; reducing the noise of the electrical signals, wherein reducing the noise comprises converting each electrical signal into a 2-D image and applying an image smoothing method to the 2-D image to reduce signal noise; calculating, for each segment, a highest statistical difference Si between the electrical signal in that segment and background noise; calculating a dynamic threshold h; determining whether Si>h in at least 50% of the segments; and increasing the stimulation voltage until an evoked potential is detected; and localizing the evoked potential in one of the patient's muscles in the plurality of the patient's muscles; wherein the evoked potential is detected if Si>h in at least 50% of the segments.

17 . The method of claim 16 , further comprising extracting at least one feature of the evoked potential.

18 . The method of claim 17 , wherein the feature is one of a peak-to-peak interval, a min-max interval, an activation latency, and an integrated EMG.

19 . The method of claim 16 , wherein the image smoothing method is a Gaussian Markov Random Field model.

20 . A method for determining the location of a muscle activation potential evoked from epidural stimulation and minimum voltage required to evoke activation potential, comprising:
delivering a plurality of epidural stimulations to a patient at a stimulation voltage; recording electrical signals from a plurality of the patient's muscles; dividing the electrical signals into sequential segments; reducing the noise of the electrical si

Assignees

• Univ Louisville Res Found Inc

Inventors

• Harkema Susan J
• El-Baz Ayman
• Angeli Claudia
• Mesbah Samineh

Classifications

• A61B5/389 Primary

  Electromyography [EMG] · CPC title

• G06T5/70

  Denoising; Smoothing · CPC title

• A61B5/743

  Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61B5/7253

  characterised by using transforms · CPC title