De novo synthesized gene libraries
US-2016354752-A1 · Dec 8, 2016 · US
Variant nucleic acid libraries for glycans
US12553151B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12553151-B2 |
| Application number | US-202217734996-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 2, 2022 |
| Priority date | May 3, 2021 |
| Publication date | Feb 17, 2026 |
| Grant date | Feb 17, 2026 |
How to read this patent
A practical reading order for non-experts. Skip the full description unless you need deep technical detail.
- Title
What the patent document calls the invention.
- Abstract
A short plain-language summary of the technical disclosure.
- Assignees and inventors
Who owns or filed the patent and who is credited as inventor.
- Key dates
Filing, priority, publication, and grant dates set the timeline.
- First independent claim
The legal scope of protection — read this for what is actually claimed.
- CPC / IPC classifications
Technology tags used to group this patent with similar filings.
- Citations and related patents
Prior art links and similar publications in this corpus.
Abstract
Official abstract text for this publication.
Provided herein are methods and compositions relating to glycan libraries having nucleic acids encoding for a scaffold comprising a glycan domain. Glycan libraries described herein encode for immunoglobulins such as antibodies.
First claim
Opening claim text (preview).
What is claimed is: 1 . A nucleic acid library, comprising: a plurality of nucleic acids, wherein each of the nucleic acids encodes for a sequence that when translated encodes for a glycan binding immunoglobulin, wherein the glycan binding immunoglobulin comprises a variant of a glycan binding domain, wherein the glycan binding domain is a ligand for the glycan, and wherein the nucleic acid library comprises at least 10,000 variant immunoglobulin variable domain, heavy chains (VH) and at least 10,000 variant immunoglobulin variable domain, light chains (VL). 2 . The nucleic acid library of claim 1 , wherein the nucleic acid library comprises at least 10 5 non-identical nucleic acids. 3 . The nucleic acid library of claim 1 , wherein a length of the immunoglobulin VH when translated is about 90 to about 100 amino acids. 4 . The nucleic acid library of claim 1 , wherein a length of the immunoglobulin VH when translated is about 100 to about 400 amino acids. 5 . A vector library comprising the nucleic acid library of claim 1 . 6 . A cell library comprising the nucleic acid library of claim 1 .
Assignees
Inventors
Classifications
Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display · CPC title
Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody® · CPC title
against material not provided for elsewhere {, e.g. haptens, metals, DNA, RNA, amino acids} · CPC title
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies · CPC title
- C40B40/08Primary
Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries · CPC title
Patent family
Related publications grouped by family.
External sources
Frequently asked questions
Answers are generated from the same data shown on this page.
- What does patent US12553151B2 cover?
- Provided herein are methods and compositions relating to glycan libraries having nucleic acids encoding for a scaffold comprising a glycan domain. Glycan libraries described herein encode for immunoglobulins such as antibodies.
- Who is the assignee on this patent?
- Twist Bioscience Corp
- What technology area does this patent fall under?
- Primary CPC classification C40B40/08. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 17 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).