System and method for adjusting insulin delivery

Patent metadata

Field	Value
Publication number	US-12551621-B2
Application number	US-202318162033-A
Country	US
Kind code	B2
Filing date	Jan 31, 2023
Priority date	Jan 13, 2017
Publication date	Feb 17, 2026
Grant date	Feb 17, 2026

Abstract

The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include adjusting user specific dosage parameters in response to one or more back-filled time segments associated with a diurnal time block.

First claim

What is claimed is:

1 . A method comprising:
receiving a user input comprising a total daily dose of insulin and patient weight; generating an insulin delivery profile based on the user input including the total daily dose of insulin and the patient weight; delivering insulin based on the insulin delivery profile and responsive to glucose values received; determining multiple sets of one or more glucose target values based on the glucose values received and the user input including the total daily dose of insulin and the patient weight: determining variations of predicted glucose values from the multiple sets of one or more glucose target values: performing an evaluation of the variations of predicted glucose values; selecting a set of one or more glucose target values from the multiple sets of one or more glucose target values based on the evaluation; adjusting the insulin delivery profile based on the set of one or more glucose target values selected; and delivering the insulin based on the adjusted insulin delivery profile.

2 . The method of claim 1 , wherein generating the inulin delivery profile includes determining user specific dosage parameters including a baseline basal rate based on the user input including the total daily dose of insulin and the patient weight and utilizing the baseline basal rate to determine the insulin delivery profile.

3 . The method of claim 1 , wherein the insulin delivery profile comprises a series of insulin delivery action.

4 . The method of claim 1 , wherein determining the variations of predicted glucose values from the multiple sets of one or more glucose target values includes generating a prediction of future glucose levels at various points in time.

5 . The method of claim 4 , wherein determining variations of predicted glucose values from the multiple sets of one or more glucose target values is based at least in part on an effect of one or more parameters chosen from among glucose, insulin, carbohydrates, and other disturbances projected at the various points in time.

6 . The method of claim 1 , wherein performing the evaluation of variations of predicted glucose values utilizes a cost function to evaluate differences between predicted future glucose values and the multiple sets of one or more glucose target values.

7 . The method of claim 6 , wherein selecting the set of one or more glucose target values from the multiple sets of one or more glucose target values based on the evaluation comprises minimizing the cost function to select the set of one or more glucose target values that minimizes differences between respective predicted future glucose values and the multiple sets of one or more glucose target values.

8 . The method of claim 1 , wherein selecting the set of one or more glucose target values from the multiple sets of one or more glucose target values based on the evaluation comprises minimizing differences between respective predicted glucose values from the multiple sets of one or more glucose target values.

9 . The method of claim 1 , further comprising adjusting the insulin delivery profile based on detected time periods for when a basal delivery differed from a baseline delivery rate.

10 . A system comprising:
an insulin delivery mechanism; and one or more controllers configured to:
receive a user input comprising a total daily dose of insulin and patient weight;
generate an insulin delivery profile based on the user input including the total daily dose of insulin and the patient weight; and
cause the insulin delivery mechanism to deliver insulin based on the insulin delivery profile and responsive to glucose values received;
determine multiple sets of one or more glucose target values based on the glucose values received and the user input including the total daily dose of insulin and the patient weight;
determine variations of predicted glucose values from the multiple sets of one or more glucose target values;
perform an evaluation of the variations of predicted glucose values;
select a set of one or more glucose target values from the multiple sets of one or more glucose target values based on the evaluation;
adjust the insulin delivery profile based on the set of one or more glucose target values selected; and
deliver the insulin based on the adjusted insulin delivery profile.

11 . The system of claim 10 , further comprising:
a pump assembly, the pump assembly comprising the insulin delivery mechanism and a first controller configured to cause the insulin delivery mechanism to deliver the insulin; and a second controller in communication with the pump assembly, the second controller configured to receive the user input comprising a total daily dose of insulin and patient weight, wherein the one or more controllers comprises the first controller and the second controller.

12 . The system of claim 10 , wherein generating the inulin delivery profile includes determining user specific dosage parameters including a baseline basal rate based on the user input including the total daily dose of insulin and the patient weight and utilizing the baseline basal rate to determine the insulin delivery profile.

13 . The system of claim 10 , wherein the insulin delivery profile comprises a series of insulin delivery action.

14 . The system of claim 10 , wherein determining the variations of predicted glucose values from the multiple sets of one or more glucose target values includes generating a prediction of the future glucose levels at various points in time.

15 . The system of claim 14 , wherein determining variations of predicted glucose values from the multiple sets of one or more glucose target values is based at least in part on an effect of one or more parameters chosen from among glucose, insulin, carbohydrates, and other disturbances projected at the various points in time.

16 . The system of claim 10 , wherein performing the evaluation of variations of predicted glucose values utilizes a cost function to evaluate differences between predicted future glucose values and the multiple sets of one or more glucose target values.

17 . The system of claim 16 , wherein selecting the set of one or more glucose target values from the multiple sets of one or more glucose target values based on the evaluation comprises minimizing the cost function to select the set of one or more glucose target values that minimizes differences between respective predicted future glucose values and the multiple sets of one or more glucose target values.

18 . The system of claim 10 , wherein the one or more controllers configured to adjust the insulin delivery profile based on detected time periods for when a basal delivery differed from a baseline delivery rate.

Assignees

• Insulet Corp

Inventors

• Mazlish Bryan
• Desborough Lane
• Naylor Ross

Classifications

• G16H40/63

  for local operation · CPC title

• A61M2205/3569

  sublocal, e.g. between console and disposable · CPC title

• A61M2205/3379

  Masses, volumes, levels of fluids in reservoirs, flow rates · CPC title

• A61M2205/3584

  using modem, internet or Bluetooth® · CPC title

• A61M2205/8206

  battery-operated · CPC title