Methods and techniques for processing responses of an olfactory test

Patent metadata

Field	Value
Publication number	US-12548641-B2
Application number	US-202218573920-A
Country	US
Kind code	B2
Filing date	Jun 29, 2022
Priority date	Jul 2, 2021
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

An olfactory test comprising an olfactory test article including a plurality of trials that each has an associated concentration of a stimulus of interest. Aspects of the present disclosure further relate to software application that guides a user through conducting the olfactory test based at least in part on the user's responses to trials of the olfactory test article, such that the user can be guided through a custom order of trials, and therefore different concentrations of the stimuli of interest, based at least in part on the user's responses to the trials as the user performs the olfactory test.

First claim

The invention claimed is:

1 . A computerized method for processing responses of an olfactory test performed by a user, the computerized method comprising:
receiving, by a computing device, data representative of a plurality of responses, each response indicating whether or not the user detects one or more stimuli of an olfactory test article, wherein the olfactory test article comprises a plurality of trials, wherein a trial of the plurality of trials comprises a sealable tab and a stimulus that is provided therewith; accessing, by the computing device, stored information comprising a plurality of possible series of trials and responses, wherein each possible series of trials and responses is associated with a recommended next trial of the plurality of trials; determining, by the computing device and for each of the plurality of responses, a next trial for the user to perform by (i) matching the data representative of the plurality of responses to a series of trials and responses of the plurality of possible series of trials and responses, (ii) determining, based on the plurality of responses, a parameter of an odor detection threshold that corresponds to a steepest slope, and (iii) determining a remaining number of trials for determining the odor detection threshold based at least in part on the parameter; generating, by the computing device and for each of the plurality of responses, an instruction based at least in part on the next trial; and providing, by the computing device and to a user interface rendered by the computing device, a set of one or more trials from the plurality of trials in accordance with the instruction.

2 . The computerized method of claim 1 , further comprising:
generating a measure corresponding to the odor detection threshold based at least in part on the plurality of responses.

3 . The computerized method of claim 1 , wherein the one or more stimuli comprise one or more concentrations of one or more odorants.

4 . The computerized method of claim 3 , wherein the one or more odorants comprise phenyl ethyl alcohol.

5 . The computerized method of claim 3 , wherein the one or more odorants comprise at least one of: butanol, beta-ionone, rotundone, androstenone, or a trigeminal stimulant.

6 . The computerized method of claim 1 , further comprising:
determining a recommended next trial for each of the plurality of possible series of trials and responses by calculating an expected value and standard error of an estimate for a parameter of interest for each potential response to each of one or more unperformed trials of the plurality of trials; and storing the recommended next trial for each of the plurality of possible series of trials and responses.

7 . The computerized method of claim 6 , wherein determining the recommended next trial for each of the plurality of possible series of trials and responses further comprises determining a trial of the one or more unperformed trials that minimized the standard error of the estimate for the parameter of interest.

8 . The computerized method of claim 1 , further comprising:
classifying the user as normosmic, hyposmic, or anosmic based at least in part on the plurality of responses.

9 . A device configured to process responses of an olfactory test performed by a user, the device comprising:
at least one computer processor; and at least one storage device encoded with a plurality of computer-executable instructions that, when executed by the at least one computer processor cause the device to at least: receive data representative of a plurality of responses, each response indicating whether or not the user detects one or more stimuli of an olfactory test article, wherein the olfactory test article comprises a plurality of trials, wherein a trial of the plurality of trials comprises a sealable tab and a stimulus that is provided therewith; access stored information comprising a plurality of possible series of trials and responses, wherein each possible series of trials responses is associated with a recommended next trial of the plurality of trials; determine, for each of the plurality of responses, a next trial for the user to perform by (i) matching the data representative of the plurality of responses to a series of trials and responses of the plurality of possible series of trials and responses, (ii) determining, based on the plurality of responses, a parameter of an odor detection threshold that corresponds to a steepest slope, and (iii) determining a remaining number of trials for determining the odor detection threshold based at least in part on the parameter; generate, for each of the plurality of responses, an instruction based at least in part on the next trial; and provide, to a user interface rendered by a computing device, a set of one or more trials from the plurality of trials in accordance with the instruction.

10 . The device of claim 9 , further comprising the device configured to:
generate a measure corresponding to the odor detection threshold based at least in part on the plurality of responses.

11 . The device of claim 9 , wherein the one or more stimuli comprise one or more concentrations of one or more odorants.

12 . The device of claim 11 , wherein the one or more odorants comprise phenyl ethyl alcohol.

13 . The device of claim 11 , wherein the one or more odorants comprise at least one of: butanol, beta-ionone, rotundone, androstenone, or a trigeminal stimulant.

14 . The device of claim 9 , further comprising the device configured to:
determine a recommended next trial for each of the plurality of possible series of trials and responses by calculating an expected value and standard error of an estimate for a parameter of interest for each potential response to each of one or more unperformed trials of the plurality of trials; and store the recommended next trial for each of the plurality of possible series of trials and responses.

15 . The device of claim 14 , wherein determining the recommended next trial for each of the plurality of possible series of trials and responses further comprises determining a trial of the one or more unperformed trials that minimized the standard error of the estimate for the parameter of interest.

16 . The device of claim 9 , further comprising the device configured to:
classify the user as normosmic, hyposmic, or anosmic based at least in part on the plurality of responses.

17 . An olfactory test article comprising:
a plurality of trials, wherein a trial of the plurality of trials comprises a sealable tab and a stimulus that is provided therewith, wherein (i) a set of one or more trials from the plurality of trials is provided to a user interface, (ii) the user interface is rendered by a computing device in accordance with an instruction that is generated by the computing device, and (iii) the instruction is generated by:
receiving data representative of a plurality of responses, each response indicating whether or not a user detects one or more stimuli for the set of one or more trials;
accessing stored information comprising a plurality of possible series of trials and responses, wherein each possible series of trials responses is associated with a recommended next trial of the plurality of trials;
determining, for each of the plurality of responses, a next trial for the user to perform by (i) matching the data to a series of trials and responses of the plurality of possible series of trials and responses, (ii) determining, based on the plurality of responses, a parameter of an odor detection thresho

Assignees

• Univ Florida
• Univ Arizona State
• Penn State Res Found

Inventors

• Munger Steven Dunn
• Hayes John E
• Gerkin Richard

Classifications

• G16H10/20 Primary

  for electronic clinical trials or questionnaires · CPC title

• A61B5/4011 Primary

  Evaluating olfaction, i.e. sense of smell · CPC title