Benzopyrazole compound

Patent metadata

Field	Value
Publication number	US-12545648-B2
Application number	US-202017789662-A
Country	US
Kind code	B2
Filing date	Dec 30, 2020
Priority date	Dec 31, 2019
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

Disclosed is a benzopyrazole compound. Specifically disclosed are a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.

First claim

The invention claimed is:

1 . A compound represented by formula (I) or a pharmaceutically acceptable salt thereof,

wherein,
X is selected from NH and O;
ring A is selected from

and the

are optionally substituted by 1, 2 or 3 R a ;
T 1 is selected from CH 2 and O;
each of T 2 , T 3 and T 4 is independently selected from CH and N;
T 5 is selected from NH and O;
T 6 is selected from CH and N;
ring B is selected from phenyl;
R 1 is selected from H and C 1-3 alkoxy, and the C 1-3 alkoxy is optionally substituted by 1, 2 or 3 R b ;
each of R 2 is independently selected from H, F, Cl, Br and CH 3 ;
R 3 is selected from C 1-6 alkyl, and the C 1-6 alkyl is optionally substituted by 1, 2 or 3 R c ;
m is selected from 0, 1 and 2;
n is selected from 1 and 2;
each of R a is independently selected from H and C 1-3 alkyl, and the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R;
each of R b is independently selected from H, F, Cl, Br and I;
each of R c is independently selected from H, F, Cl, Br, I and OH;
each of R is independently selected from F and OCH 3 .

2 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein the compound is selected from

3 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein each of R a is independently selected from H, CH 3 , CF 3 , CH 2 CH 3 , C(CH 3 ) 2 and CH 2 CH 2 OCH 3 .

4 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein ring A is selected from

and the

are optionally substituted by 1, 2 or 3R a .

5 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 4 , wherein ring A is selected from

and are optionally substituted by 1, 2 or 3 R a .

6 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 5 , wherein ring A is selected from

7 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein the structural moiety

is selected from

8 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 7 , wherein the structural moiety

selected from

9 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein R 1 is selected from H and OCH 3 , and the OCH 3 is optionally substituted by 1, 2 or 3 R b .

10 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 9 , wherein R 1 is selected from H and OCH 3 .

11 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein R 3 is selected from C 1-3 alkyl, and the C 1-3 alkyl is optionally substituted by 1, 2 or 3 R.

12 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 11 , wherein R 3 is selected from CH 3 , CH 2 CH 3 and C(CH 3 ) 2 .

13 . The compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 , wherein the compound is selected from

14 . A compound represented by the following formula or a pharmaceutically acceptable salt thereof, and the compound is selected from

15 . A method for treating diseases related to glucocorticoid receptors in a subject in need thereof, comprising: administering an effective amount of the compound or the pharmaceutically acceptable salt thereof as claimed in claim 1 to the subject.

16 . The method as claimed in claim 15 , wherein the diseases related to glucocorticoid receptors are rheumatoid arthritis.

Assignees

• Medshine Discovery Inc

Inventors

• Su Sheng
• Wei Xiawei
• Luo Yunfu
• Zhang Guoli
• Wang Yong
• Chen Shuhui

Classifications

• C07D498/04

  Ortho-condensed systems · CPC title

• C07D487/04

  Ortho-condensed systems · CPC title

• C07D471/04

  Ortho-condensed systems · CPC title

• C07D417/04

  directly linked by a ring-member-to-ring-member bond · CPC title

• C07D413/04

  directly linked by a ring-member-to-ring-member bond · CPC title