Macroencapsulation devices

Patent metadata

Field	Value
Publication number	US-12544545-B2
Application number	US-202017600670-A
Country	US
Kind code	B2
Filing date	Apr 2, 2020
Priority date	Apr 3, 2019
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

The present disclosure relates to macroencapsulation devices and related methods of manufacture where the membranes of a device may be mounted to an associated frame in a relaxed, or slack, configuration prior to filling with a desired material.

First claim

What is claimed is:

1 . A macroencapsulation device for housing a population of cells comprising:
a first membrane; a second membrane disposed on the first membrane, wherein the first membrane and the second membrane are bonded along a perimeter of the first and second membranes to form an internal volume there between, wherein the first membrane and/or the second membrane is semipermeable; and a frame that extends along at least a portion of the perimeter of the first and second membranes, and wherein a surface area of the first and/or second membrane is greater than a transverse cross sectional area of the frame in a plane in which the frame extends and the first and second membranes are mounted within; wherein the internal volume is configured to house the population of cells.

2 . The macroencapsulation device of claim 1 , wherein the frame extends completely around the perimeter of the first and second membranes.

3 . The macroencapsulation device of claim 1 , wherein the first and second membranes are configured to block passage of the population of cells out of the device.

4 . The macroencapsulation device of claim 3 , further comprising the population of cells disposed in the internal volume.

5 . The macroencapsulation device of claim 1 , wherein the internal volume includes a plurality of channels.

6 . The macroencapsulation device of claim 5 , further comprising a plurality of bonded portions of the first and second membrane disposed radially inward from the frame that form the plurality of channels, and wherein at least some of the bonded portions include a through hole passing there through.

7 . The macroencapsulation device of claim 1 , wherein the first membrane and/or the second membrane is sintered.

8 . The macroencapsulation device of claim 1 , wherein the first and/or second membranes includes a hydrophilic coating.

9 . The macroencapsulation device of claim 1 , wherein the plane in which the frame extends is a plane in which a maximum transverse dimension of the macroencapsulation device is located.

10 . The macroencapsulation device of claim 1 , wherein the plane in which the frame extends is a plane in which the first and/or second membrane are mounted.

11 . The macroencapsulation device of claim 1 , wherein the first membrane is directly bonded to the second membrane.

12 . A macroencapsulation device for housing a population of cells comprising:
a first membrane; a second membrane disposed on the first membrane, wherein the first membrane and the second membrane are bonded along a perimeter of the first and second membranes to form an internal volume there between, wherein the first membrane and/or the second membrane is semipermeable; and a frame that extends along at least a portion of the perimeter of the first and second membranes, and wherein a portion of the first and second membranes connected to the frame is deformed to fit within an area of the frame that is smaller than an area of the portion of the first and second membranes in an undeformed configuration; wherein the internal volume is configured to house the population of cells.

13 . The macroencapsulation device of claim 12 , wherein the portion of the first and second membranes connected to the frame includes a plurality of locations disposed around a perimeter of the frame where the first and second membranes are deformed from a first larger area to a second smaller area.

14 . The macroencapsulation device of claim 12 , wherein a surface area of the first and/or second membrane is greater than a transverse cross sectional area of the frame the first and second membranes are mounted within.

15 . The macroencapsulation device of claim 12 , wherein the frame extends completely around the perimeter of the first and second membranes.

16 . The macroencapsulation device of claim 12 , wherein the first and second membranes are configured to block passage of the population of cells out of the device.

17 . The macroencapsulation device of claim 16 , further comprising the population of cells disposed in the internal volume.

18 . The macroencapsulation device of claim 12 , wherein the internal volume includes a plurality of channels.

19 . The macroencapsulation device of claim 18 , further comprising a plurality of bonded portions of the first and second membrane disposed radially inward from the frame that form the plurality of channels, and wherein at least some of the bonded portions include a through hole passing there through.

20 . The macroencapsulation device of claim 12 , wherein the first membrane and/or the second membrane is sintered.

21 . The macroencapsulation device of claim 12 , wherein the first and/or second membranes includes a hydrophilic coating.

22 . The macroencapsulation device of claim 12 , wherein the first membrane is directly bonded to the second membrane.

23 . The macroencapsulation device of claim 12 , wherein the area of the frame is along a plane in which the first and/or second membrane is mounted.

Assignees

• Vertex Pharma

Inventors

• Thanos Christopher
• Lavin Danya M
• Mills John
• Billings Megan

Classifications

• B01D2325/0283

  Pore size · CPC title

• C12N5/0676

  Pancreatic cells · CPC title

• A61K35/39

  Pancreas; Islets of Langerhans (Langerhans cells of epidermis A61K35/36) · CPC title

• A61K9/0024

  Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue (compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L) · CPC title

• A61F2/022 Primary

  Artificial gland structures using bioreactors (hemodialysis A61M1/16; hemofiltration A61M1/34; other extracorporeal blood treatment A61M1/36) · CPC title