Fiber-hydrogel composite surgical meshes for tissue repair

Patent metadata

Field	Value
Publication number	US-12544489-B2
Application number	US-202217733797-A
Country	US
Kind code	B2
Filing date	Apr 29, 2022
Priority date	Aug 17, 2015
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of laminar composite is disclosed for the purpose of reducing foreign body response, managing tissue-materials interface, and improving the integration of the surgical mesh with the surrounding tissue of a subject.

First claim

What is claimed is:

1 . A surgical device comprising:
i) a scaffold complex comprising polymeric fibers having a mean diameter of from 100 nm to 8000 nm covalently linked to a hydrogel material; wherein the scaffold complex comprises a plurality of pores present on or within a surface of the scaffold complex, wherein the pores are present at a concentration of at least 50 pores per cm 2 , and wherein at least 80% of the pores have an average pore diameter of at least 5 microns; and ii) a surgical mesh material.

2 . The device of claim 1 wherein the polymeric fibers are dispersed throughout the hydrogel material.

3 . The device of claim 1 , wherein the hydrogel material comprises hyaluronic acid.

4 . The device of claim 1 , wherein the polymeric fibers comprise a polyester.

5 . The device of claim 1 , wherein the polymeric fibers comprise a functionalized polycaprolactone.

6 . The device of claim 3 , wherein the polymeric fibers comprise a functionalized polycaprolactone.

7 . The device of claim 1 , wherein the surgical mesh comprises a polypropylene.

8 . The device of claim 1 , configured as a sheet having a first dimension and a second dimension independently at least five times as great in length as a third dimension.

9 . The device of claim 8 , wherein the third dimension is less than 1 cm.

10 . The device of claim 8 , wherein the third dimension is less than 5 mm.

11 . The device of claim 8 , wherein the third dimension is less than 1 mm.

12 . The device of claim 8 , wherein the first dimension and second dimension are independently greater than 1 cm.

13 . The device of claim 8 , wherein the first dimension and second dimension are independently greater than 1 cm.

14 . The device of claim 1 , configured to be subdermally implantable in a human subject in need thereof.

15 . A medical device for use in a subject undergoing a surgical procedure, comprising the device of claim 1 in an amount effective to provide for the reinforcement and/or regeneration of one or more tissues including skin, fascia, pleura, dura, pericardium, paratenon, periosteum, perineurium, blood vessel wall, lymphatic wall when administered to the subject, or the reinforcement or coverage of a medical implant when administered to the subject.

Assignees

• Univ Johns Hopkins

Inventors

• Martin Russell
• Reddy Sashank
• Sacks Justin
• Li Xiaowei
• Cho Brian Honewee
• Mao Hai-Quan

Classifications

• A61L2430/34

  for soft tissue reconstruction · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L27/3633

  Extracellular matrix [ECM] · CPC title

• A61F2250/0067

  Means for introducing or releasing pharmaceutical products into the body · CPC title

• A61F2210/0061

  swellable · CPC title