Fat composition and nutritional composition based thereon

Patent metadata

Field	Value
Publication number	US-12544405-B2
Application number	US-202017431957-A
Country	US
Kind code	B2
Filing date	Feb 27, 2020
Priority date	Mar 1, 2019
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

The invention relates to a fat composition and a nutritional composition comprising such fat composition. The nutritional composition is particularly suitable for therapeutic applications in treating gut discomfort and/or constipation as well as in non-therapeutic applications for reducing the intestinal formation of calcium and magnesium fatty acid soaps. The fat composition comprises a mixture of triacylglycerols (TAG) originating from a bovine milk fat source and a vegetable lipid source, said mixture being characterized by: (a) a content of butanoate groups (C4:0) of 0.5-2.8% by weight based on total weight of fatty acid acyl groups in TAG; (b) a wLCSFA(sn-1,3) of 18.0-35.0% by weight; (c) a mLCFA (sn-1,3) of 48.0-61.0 mol %; and (d) a ratio mLCFA (sn-1,3)/SFA of 0.70-1.25, wherein: —LCFA(sn-1,3) are the long chain fatty acid acyl groups having a chain length of 12 or more carbon atoms at the sn-1 and sn-3 position in TAG; —LCSFA(sn-1,3) are the long chain saturated fatty acid acyl groups having a chain length of 12 or more carbon atoms at the sn-1 and sn-3 position in TAG; —wLCSFA(sn-1,3) is the amount of LCFA(sn-1,3) in % by weight based on total weight of fatty acid acyl groups in TAG; —mLCFA(sn-1,3) is the mole fraction of LCFA(sn-1,3) based on total moles of fatty acid acyl groups in the TAG as expressed in mol %; and—SFA is the mole fraction of saturated fatty acid acyl groups in the TAG as expressed in mol %.

First claim

The invention claimed is:

1 . A fat composition comprising a mixture of triacylglycerols (TAG) originating from a bovine milk fat source and a vegetable lipid source, said mixture comprising:
(a) a content of butanoate groups (C4:0) of 0.5-2.8% by weight, based on total weight of fatty acid acyl groups in TAG; (b) a wLCSFA(sn-1,3) of 18.0-35.0% by weight; (c) a mLCFA (sn-1,3) of 48.0-61.0 mol %, preferably 50.0-59.0 mol %; and (d) a ratio mLCFA (sn-1,3)/SFA of 0.70-1.25, wherein:
LCFA(sn-1,3) are the long chain fatty acid acyl groups having a chain length of 12 or more carbon atoms at the sn-1 and sn-3 position in TAG;
LCSFA(sn-1,3) are the long chain saturated fatty acid acyl groups having a chain length of 12 or more carbon atoms at the sn-1 and sn-3 position in TAG;
wLCSFA(sn-1,3) is the amount of LCSFA(sn-1,3) in % by weight based on total weight of fatty acid acyl groups in TAG;
mLCFA(sn-1,3) is the mole fraction of LCFA(sn-1,3) based on total moles of fatty acid acyl groups in the TAG as expressed in mol %; and
SFA is the mole fraction of saturated fatty acid acyl groups in the TAG as expressed in mol %.

2 . The fat composition according to claim 1 , wherein:
the content of butanoate groups (C4:0) is 0.5-2.2% by weight, based on total weight of fatty acid acyl groups in TAG; and the ratio mLCFA (sn-1,3)/SFA is 0.95-1.25.

3 . The fat composition according to claim 1 comprising 10-60 wt %, based on total weight of TAG, of TAG originating from the bovine milk fat source.

4 . The fat composition according to claim 3 , wherein the bovine milk fat source is whole milk and/or cream.

5 . A nutritional composition comprising proteins, carbohydrates and a lipid source, wherein the lipid source comprises the fat composition according to claim 1 .

6 . The nutritional composition according to claim 5 , wherein the nutritional composition has a ratio

mLCFA
⁡

(

sn
-
1

,
3

)

*

(

Ca
+
Mg

)

SFA

in the range of 0.40 to 0.75 grams per 100 grams of nutritional composition (g/100 g),
wherein (Ca+Mg) is a concentration of calcium plus a concentration of magnesium in the nutritional composition in g/100 g.

7 . A method of treating gut discomfort and/or constipation in a subject, the method comprising administering to the subject an effective amount of the nutritional composition of claim 5 , wherein the subject is a human subject of 0-36 months of age.

8 . A method of reducing intestinal formation of calcium and magnesium fatty acid soaps in a subject, the method comprising administering to the subject an effective amount of the nutritional composition of claim 5 .

9 . A method of treating gut discomfort and/or constipation in a subject, the method comprising administering to the subject an effective amount of the fat composition of claim 1 , wherein the subject is a human subject of 0-36 months of age.

10 . A method of reducing intestinal formation of calcium and magnesium fatty acid soaps in a subject, the method comprising administering to the subject an effective amount of the fat composition of claim 1 .

11 . The fat composition according to claim 1 , wherein the content of butanoate groups (C4:0) in the mixture is 0.6-2.7% by weight, based on total weight of fatty acid acyl groups in TAG.

12 . The fat composition according to claim 1 , wherein the content of butanoate groups (C4:0) in the mixture is 0.6-2.0% by weight, based on total weight of fatty acid acyl groups in TAG.

13 . The fat composition according to claim 1 , wherein the wLCSFA (sn-1,3) of the mixture is 19.0-32.0% by weight.

14 . The fat composition according to claim 1 , wherein the mLCFA (sn-1,3) of the mixture is 50.0-59.0 mol %.

15 . The fat composition according to claim 1 , wherein the ratio mLCFA (sn-1,3)/SFA is 0.80-1.20.

16 . The fat composition according to claim 1 , wherein the ratio mLCFA (sn-1,3)/SFA is 1.00-1.20.

Assignees

• Frieslandcampina Nederland Bv

Inventors

• Feitsma Anouk Leonie
• Kloek William
• Parikh Panam Mohit
• Timmer-Keetels Christina Josephina Antonia Maria
• Vonk Marlotte Marianne
• Rombout-Jeurink Prescilla Vera

Classifications

• A61K31/23

  of acids having a carboxyl group bound to a chain of seven or more carbon atoms · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23D9/00

  Other edible oils or fats, e.g. shortenings or cooking oils (preservation of other edible oils A23B20/30) · CPC title

• A61P1/14

  Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title