Sealing fluid for sealing capsules

Patent metadata

Field	Value
Publication number	US-12544339-B2
Application number	US-202118257002-A
Country	US
Kind code	B2
Filing date	Dec 13, 2021
Priority date	Dec 14, 2020
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

The present invention discloses a sealing fluid comprising an organic acid, an alcohol and optionally water, the organic acid is lactic acid or acetic acid, the alcohol is isopropanol or ethanol, the sealing fluid is a liquid composition for sealing telescopically joined hard capsules with coaxial partly overlapping body parts.

First claim

The invention claimed is:

1 . A hard capsule sealing fluid comprising, based on the weight of the sealing fluid:
a) at least 32.5 wt % of an organic acid selected from lactic acid or acetic acid; and b) at least 17.5 wt % of an alcohol selected from isopropanol or ethanol, wherein the sealing fluid does not contain hydroxypropyl methylcellulose (HPMC); and the sealing fluid has a viscosity of ≤100 mPa*s, with the viscosity measured at 22° C. using a rotational viscometer with a cylindrical spindle.

2 . The sealing fluid according to claim 1 , wherein the sealing fluid consists of the organic acid and the alcohol.

3 . The sealing fluid according to claim 2 , wherein the organic acid is acetic acid.

4 . The sealing fluid according to claim 2 , wherein the alcohol is isopropanol.

5 . The sealing fluid according to claim 3 , wherein based on the weight of the sealing fluid:
a) the acetic acid is in an amount ranging from 47.5 wt % to 80 wt %; and b) the alcohol is an amount ranging from 20 wt % to 52.5 wt %.

6 . The sealing fluid according to claim 1 , further comprising water, wherein based on the weight of the sealing fluid, the sum of the amounts of the organic acid, the alcohol and water is at least 97.5 wt %.

7 . The sealing fluid according to claim 6 , wherein based on the weight of the sealing fluid, the water is in an amount of at least 17.5 wt %.

8 . The sealing fluid according to claim 6 , wherein based on the weight of the sealing fluid:
a) the organic acid is acetic acid and is in an amount ranging from 40 wt % to 60 wt %; and b) the alcohol is an amount ranging from 20 wt % to 40 wt %.

9 . The sealing fluid according to claim 8 , wherein the alcohol is isopropanol.

10 . The sealing fluid according to claim 6 , wherein based on the weight of the sealing fluid:
a) the organic acid is lactic acid and is in an amount ranging from 32.5 wt % to 62.5 wt %; and b) the alcohol is an amount ranging from 17.5 wt % to 47.5 wt %.

11 . The sealing fluid according to claim 10 , wherein based on the weight of the sealing fluid, the alcohol is ethanol and is in an amount ranging from 25 wt % to 42.5 wt %.

12 . The sealing fluid according to claim 10 , wherein based on the weight of the sealing fluid:
a) the lactic acid is in an amount ranging from 37.5 wt % to 55 wt %; and b) the alcohol is isopropanol and is an amount ranging from 17.5 wt % to 42.5 wt %.

13 . The sealing fluid according to claim 12 , wherein based on the weight of the sealing fluid:
a) the lactic acid is in an amount ranging from 37.5 wt % to 45 wt %; and b) the isopropanol is an amount ranging from 35 wt % to 42.5 wt %.

14 . The sealing fluid according to claim 6 , wherein the sealing fluid consists of the organic acid, the alcohol, and water.

15 . The sealing fluid according to claim 14 , wherein the organic acid is lactic acid.

16 . The sealing fluid according to claim 14 , wherein the alcohol is isopropanol.

17 . The sealing fluid according to claim 6 , wherein based on the weight of the sealing fluid:
a) the organic acid is in the amount of 40 wt %; and b) the alcohol is the amount of 40 wt %.

18 . A method of preparing the sealing fluid of claim 1 , comprising mixing the organic acid and the alcohol.

19 . A method for sealing a hard capsule comprising applying the sealing fluid of claim 1 to the capsule.

20 . A sealed hard capsule obtainable by the method of claim 19 .

Assignees

• Capsugel Belgium Nv

Inventors

• Laurichesse Stephanie
• Palangetic Ljiljana

Classifications

• A61K9/4833

  Encapsulating processes; Filling of capsules (mechanical aspects A61J3/07) · CPC title

• A61K9/4808

  characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release (capsules filled with granules or microparticles A61K9/16; filled with microcapsules or coated microparticles A61K9/50; with mixture of different granules, microcapsules, (coated) microparticles A61K9/5084) · CPC title

• A61K9/4883

  Capsule finishing, e.g. dyeing, aromatising, polishing · CPC title

• A61K9/4858 Primary

  Organic compounds · CPC title

• A61K9/4816 Primary

  Wall or shell material · CPC title