Substance-encapsulating vesicle and process for producing the same
US-10357454-B2 · Jul 23, 2019 · US
Metabolisable pH sensitive polymersomes
US12544334B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12544334-B2 |
| Application number | US-201917046953-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 11, 2019 |
| Priority date | Apr 13, 2018 |
| Publication date | Feb 10, 2026 |
| Grant date | Feb 10, 2026 |
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- Title
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Abstract
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The present application relates to pH-sensitive polymersomes. The polymersomes are capable of degradation at endosomes' mild acidic pH into resorbable materials, which also allows avoiding liposome premature degradation of the payload once internalised inside the cells. The polymersomes can thus be used in methods for the treatment or prevention of diseases.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A polymersome that comprises: (a) a protein repellent polymer; and (b) a pH sensitive biodegradable succinate polymer comprising (i) succinate monomeric units in the polymer backbone, and (ii) a pendant group with a pKa of from 6.2 to 7, wherein the pendant group comprises an imidazole moiety. 2 . The polymersome of claim 1 , wherein the protein repellent polymer is an acrylate polymer, a polypeptide, a polyester, a polyamide, a polyanhydride, a polyurethane, a polyether, a polyimine, a polyurea, a polyacetal, a polysaccharide or a polycarbonate. 3 . The polymersome of claim 2 , wherein the protein repellent polymer comprises units of formula (I) in which R p is hydrogen or methyl and A p is a group of formula (I′) in which X p is a C 1-6 alkylene group. 4 . The polymersome of claim 1 , wherein the protein repellent polymer is poly (2-(methacryloyloxy) ethyl phosphorylcholine) or poly (ethylene oxide). 5 . The polymersome of claim 1 , wherein the imidazole moiety is imidazole, methylimidazole or dimethylimidazole. 6 . The polymersome of claim 1 , wherein the pH sensitive biodegradable succinate polymer is poly[propylene 2-((2-(2-(1H-imidazol-5-yl) acetamido)-3-(tert-butoxy)-3-oxopropyl) thio) succinate]. 7 . The polymersome of claim 1 , which further comprises a drug encapsulated within the polymersome. 8 . A pharmaceutical composition comprising: a plurality of the polymersomes of claim 1 ; and one or more pharmaceutically acceptable excipients or diluents. 9 . A method that comprises administering the polymersome of claim 1 to a subject. 10 . A method that comprises: (i) administering the polymersome of claim 7 to a subject; and (ii) releasing the drug in vivo in the subject.
Assignees
Inventors
Classifications
Manufacture or treatment of nanostructures · CPC title
Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery · CPC title
- A61K9/1273Primary
Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances · CPC title
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Frequently asked questions
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- What does patent US12544334B2 cover?
- The present application relates to pH-sensitive polymersomes. The polymersomes are capable of degradation at endosomes' mild acidic pH into resorbable materials, which also allows avoiding liposome premature degradation of the payload once internalised inside the cells. The polymersomes can thus be used in methods for the treatment or prevention of diseases.
- Who is the assignee on this patent?
- Ucl Business Ltd
- What technology area does this patent fall under?
- Primary CPC classification A61K9/1273. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Feb 10 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).