Systems, methods, and devices for monitoring and treatment of tissues within and/or through a lumen wall

Patent metadata

Field	Value
Publication number	US-12544131-B2
Application number	US-202418656031-A
Country	US
Kind code	B2
Filing date	May 6, 2024
Priority date	Nov 5, 2012
Publication date	Feb 10, 2026
Grant date	Feb 10, 2026

Abstract

A system for controlled sympathectomy procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. Systems and methods for accessing target tissues as part of a neuromodulation procedure from within a lumen are disclosed.

First claim

What is claimed is:

1 . A tool comprising:
an elongate member comprising a distal tip and a control end, the elongate member configured to extend from an entry site on a body into a lumen within the body; two or more probes coupled with the distal tip of the elongate member, the two or more probes being configured for deployment responsive to actuation at the control end; wherein each of the two or more probes comprises (i) a probe tip configured to penetrate at least one of into and through a wall of the lumen upon deployment and (ii) one or more electrodes configured to at least one of monitor and alter electrophysiological activity; and wherein the control end of the elongate member is configured:
to deploy a first one of the two or more probes such that at least one of the one or more electrodes of the first probe is proximate a first site;
to deploy a second one of the two or more probes such that at least one of the one or more electrodes of the second probe is proximate a second site;
to reference electrophysiological signals captured from the first site to electrophysiological signals captured at a third site to generate first referenced electrophysiological signals;
to reference electrophysiological signals captured from the second site to electrophysiological signals captured at the third site to generate second referenced electrophysiological signals;
to process the first referenced electrophysiological signals and the second referenced electrophysiological signals to determine electrophysiological activity originating at the first site, wherein processing the first referenced electrophysiological signals and the second referenced electrophysiological signals comprises determining a state of completion of a surgical procedure at the first site by removing dominant content of the second referenced electrophysiological signals captured at the second site from dominant content of the first referenced electrophysiological signals captured at the first site and based at least in part on monitoring for one or more population synchrony changes of the first referenced electrophysiological signals and the second referenced electrophysiological signals; and
to control at least one of the one or more electrodes of the first probe to apply a stimulating train of one or more pulses to the first site based at least in part in the determined state of completion of the surgical procedure at the first site.

2 . The tool of claim 1 , wherein the electrophysiological activity comprises electrophysiological signals related to one or more of water concentration, tissue tone, evoked potential, remotely stimulated nervous activity, sympathetic activity, an electromyographic signal [EMG], a mechanomyographic signal [MMG], a local field potential, an electroacoustic event, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity [MSNA], central sympathetic drive, nerve traffic, or combinations thereof.

3 . The tool of claim 1 , further comprising a microcircuit embedded in the elongate member and coupled to the one or more electrodes of the two or more probes, the microcircuit configured to condition the first referenced electrophysiological signals and the second referenced electrophysiological signals conveyed from the one or more electrodes to the control end of the elongate member.

4 . The tool of claim 1 , wherein the one or more electrodes of the first probe comprise one or more stimulating electrodes configured to provide at least one of a stimulating and ablating current to the first site via the stimulating train of one or more pulses.

5 . The tool of claim 1 , wherein the first probe comprises a channel fluidly coupled with the control end of the elongate member, the channel configured to deliver at least one of a diagnostic and therapeutic substance to the first site.

6 . The tool of claim 1 , wherein the first probe comprises a stabilizing element positioned at a predetermined distance from the probe tip of the first probe, the stabilizing element configured to limit a depth that the first probe penetrates into the wall of the lumen upon deployment from the elongate member.

7 . The tool of claim 1 , wherein the first probe comprises an anchor for securing the first probe to the wall of the lumen upon deployment of the first probe from the elongate member.

8 . The tool of claim 1 , further comprising one or more stabilizing members coupled to the elongate member, wherein the one or more stabilizing members comprise a plurality of wire members.

9 . The tool of claim 8 , wherein the plurality of wire members have blunt tips, the plurality of wire members being configured to curl outwardly upon deployment from the distal tip of the elongate member to bias against the wall of the lumen without puncturing the wall of the lumen.

10 . The tool of claim 8 , wherein the plurality of wire members comprises a basket catheter.

11 . The tool of claim 10 , further comprising a guiding lumen at the distal tip of the elongate member and a distal portion of the basket catheter.

12 . The tool of claim 11 , further comprising a guidewire configured for advancement and retraction through the guiding lumen.

13 . The tool of claim 8 , wherein the first probe is configured for deployment from a given one of the plurality of wire members.

14 . The tool of claim 13 , wherein the given wire member comprises a channel for communication of a fluid to the probe tip of the first probe.

15 . The tool of claim 1 , wherein the first probe is configured for deployment from the elongate member.

16 . The tool of claim 1 , further comprising one or more stabilizing members coupled to the elongate member, the one or more stabilizing members comprising one or more additional electrodes, the one or more additional electrodes being configured to at least one of monitor and alter electrophysiological activity in the vicinity of the lumen at the third site.

17 . A system comprising:
a tool comprising an elongate member and two or more probes coupled to a distal tip of the elongate member, the two or more probes being configured for deployment responsive to actuation at a control end of the elongate member, each of the two or more probes comprising (i) a probe tip configured to penetrate at least one of into and through a wall of the lumen upon deployment and (ii) one or more electrodes configured to at least one of monitor and alter electrophysiological activity; and a control unit configured to exchange signaling with the control end of the elongate member:
to deploy a first one of the two or more probes such that at least one of the one or more electrodes of the first probe is proximate a first site;
to deploy a second one of the two or more probes such that at least one of the one or more electrodes of the second probe is proximate a second site;
to reference electrophysiological signals captured from the first site to electrophysiological signals captured at a third site to generate first referenced electrophysiological signals;
to reference electrophysiological signals captured from the second site to electrophysiological signals captured at the third site to generate second referenced electrophysiological signals;
to process the first referenced electrophysiological signals and the second referenced electrophysiological signals to determine electrophysiological activity originating at the first site, wherein processing the first referenced electrophysiological signals and the second referenced electrophysiological signals comprises determining a state of completion

Assignees

• Autonomix Medical Inc

Inventors

• Toth Landy
• Martin Roy

Classifications

• A61N1/303

  Constructional details (electrodes for external use A61N1/0428) · CPC title

• A61N1/05

  for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) · CPC title

• A61B2018/00577

  Ablation · CPC title

• A61B5/7203

  for noise prevention, reduction or removal · CPC title

• A61B5/6858

  with a distal basket, e.g. expandable basket · CPC title