Labyrinthulid microorganism capable of producing microbial oil, microbial oil, methods for producing said microorganism and for producing said microbial oil, and uses of said microorganism and said microbial oil
US-11898190-B2 · Feb 13, 2024 · US
Method for producing microbial oil from labyrinthulid microorganism capable of producing said microbial oil
US12540343B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12540343-B2 |
| Application number | US-202418411156-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 12, 2024 |
| Priority date | Jul 3, 2015 |
| Publication date | Feb 3, 2026 |
| Grant date | Feb 3, 2026 |
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Abstract
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A method for producing a microbial oil includes genetically modifying a labyrinthulid which belongs to the genus Parietichytrium or the genus Schizochytrium by disrupting and/or silencing a Δ4 desaturase gene, a C20 elongase gene, and/or a C18 elongase gene, or by being transformed with an ω3 desaturase gene; culturing the labyrinthulid; and collecting the microbial oil from the labyrinthulid. The labyrinthulid has an activity of synthesizing DHA via a PUFA-PKS pathway in an amount of not more than 1/100 of a total amount of DHA synthesized in the labyrinthulid or no activity of producing PUFAs via the PUFA-PKS pathway, and the labyrinthulid has an activity of producing PUFAs via an endogenous elongase-desaturase pathway.
First claim
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The invention claimed is: 1 . A method for producing a microbial oil, comprising: genetically modifying a labyrinthulid which belongs to the genus Parietichytrium or the genus Schizochytrium by disrupting and/or silencing a Δ4 desaturase gene, a C20 elongase gene, and/or a C18 elongase gene, or by being transformed with an ω3 desaturase gene; culturing the labyrinthulid; and collecting the microbial oil from the labyrinthulid, wherein the labyrinthulid has an activity of synthesizing DHA via a PUFA-PKS pathway in an amount of not more than 1/100 of a total amount of DHA synthesized in the labyrinthulid or no activity of producing PUFAs via the PUFA-PKS pathway, and the labyrinthulid has an activity of producing PUFAs via an endogenous elongase-desaturase pathway. 2 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of DTA as compared with the microbial oil collected from the labyrinthulid whose Δ4 desaturase gene is not disrupted or silenced. 3 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of n-3 DPA as compared with the microbial oil collected from the labyrinthulid whose Δ4 desaturase gene is not disrupted or silenced. 4 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of EPA as compared with the microbial oil collected from the labyrinthulid whose C20 elongase gene is not disrupted or silenced. 5 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of ARA as compared with the microbial oil collected from the labyrinthulid whose C20 elongase gene is not disrupted or silenced. 6 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of STA as compared with the microbial oil collected from the labyrinthulid whose C18 elongase gene is not disrupted or silenced. 7 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of GLA as compared with the microbial oil collected from the labyrinthulid whose C18 elongase gene is not disrupted or silenced. 8 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of EPA as compared with the microbial oil collected from the labyrinthulid which is not transformed with the 03 desaturase gene. 9 . The method according to claim 1 , wherein the microbial oil comprises an increased amount of ETA as compared with the microbial oil collected from the labyrinthulid which is not transformed with the 03 desaturase gene. 10 . The method according to claim 1 , wherein the labyrinthulid belonging to the genus Parietichytrium is Parietichytrium sp. SEK358 (FERM BP-11405), Parietichytrium sarkarianum SEK364 (FERM BP-11298), or Parietichytrium sp. SEK571 (FERM BP 11406), and/or wherein the labyrinthulid belonging to the genus Schizochytrium is Schizochytrium aggregatum ATCC 28209.
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Classifications
Algae {; Processes using algae} · CPC title
Microorganisms {; Processes using microorganisms} · CPC title
Genes encoding for enzymes or proenzymes · CPC title
Unicellular algae isolates · CPC title
Microorganisms; Compositions thereof (medicinal preparations containing material from protozoa, bacteria or viruses A61K35/66, from algae A61K36/02, from fungi A61K36/06; preparing medicinal bacterial antigen or antibody compositions, e.g. bacterial vaccines, A61K39/00); Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor · CPC title
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- What does patent US12540343B2 cover?
- A method for producing a microbial oil includes genetically modifying a labyrinthulid which belongs to the genus Parietichytrium or the genus Schizochytrium by disrupting and/or silencing a Δ4 desaturase gene, a C20 elongase gene, and/or a C18 elongase gene, or by being transformed with an ω3 desaturase gene; culturing the labyrinthulid; and collecting the microbial oil from the labyrinthul…
- Who is the assignee on this patent?
- Univ Kyushu Nat Univ Corp, Konan Gakuen, Nippon Suisan Kaisha Ltd
- What technology area does this patent fall under?
- Primary CPC classification C12P7/6432. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Feb 03 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 5 related publications on this page (citations in our corpus or others sharing the same primary CPC).