Systems, devices and methods for dispensing biocompatible reactive formulations and controlling cross-linking of the reactive components of the biocompatible reactive formulations

Patent metadata

Field	Value
Publication number	US-12539374-B2
Application number	US-202217672807-A
Country	US
Kind code	B2
Filing date	Feb 16, 2022
Priority date	Feb 19, 2021
Publication date	Feb 3, 2026
Grant date	Feb 3, 2026

Abstract

A system for dispensing a biocompatible reactive formulation includes a first chamber containing a first fluid having a first reactive component, a second chamber containing a second fluid having a second reactive component, and a third chamber containing a third fluid.

First claim

What is claimed is:

1 . A system for dispensing a biocompatible reactive formulation, the system comprising:
a spray tip housing having a proximal end, a distal end, an outer wall that extends from said proximal end to said distal end of said spray tip housing, and an elongated conduit surrounded by said outer wall that extends from said proximal end to said distal end of said spray tip housing; a fluid connector secured to said proximal end of said spray tip housing and opposing a proximal end of a mixing element, said fluid connector including:
first and second fluid channels in fluid communication with a mixing chamber, said first and second fluid channels comprising first and second fluid inlet openings, first and second fluid exit openings, and first and second fluid conduits extending between said first and second fluid inlet openings and said first and second fluid exit openings, respectively; and
a third fluid channel in fluid communication with a third fluid inlet opening of said mixing element;
said mixing element disposed within said elongated conduit of said spray tip housing; and said mixing chamber located between an outer surface of said mixing element and an inner surface of said outer wall of said spray tip housing; said mixing element including:
said proximal end adjacent said proximal end of said spray tip housing and a distal end adjacent said distal end of said spray tip housing;
said third fluid inlet opening at said proximal end of said mixing element; and
one or more third fluid exit openings formed in said outer surface of said mixing element that are in fluid communication with said third fluid inlet opening, wherein said one or more third fluid exit openings extend laterally through said mixing element to said outer surface of said mixing element for being in fluid communication with said mixing chamber.

2 . The system as claimed in claim 1 , wherein said mixing element further comprises a third fluid conduit extending distally from said third fluid inlet opening of said mixing element toward said distal end of said mixing element for interconnecting said third fluid inlet opening and said one or more third fluid exit openings of said mixing element.

3 . The system as claimed in claim 2 , wherein said fluid connector has a proximal end and a distal end, and wherein said distal end of said fluid connector is disposed within said elongated conduit of said spray tip housing and opposes said proximal end of said mixing element.

4 . The system as claimed in claim 3 , wherein said first, second and third fluid channels of said fluid connector extend from said proximal end to said distal end of said fluid connector, and wherein said first, second and third fluid channels are isolated from one another within said fluid connector.

5 . The system as claimed in claim 4 , wherein said third fluid channel of said fluid connector extends through a central region of said fluid connector, and wherein said first and second fluid channels of said fluid connector extend on opposite sides of said third fluid channel.

6 . The system as claimed in claim 2 , wherein said one or more third fluid exit openings are located adjacent said distal end of said mixing element, and wherein said third fluid conduit of said mixing element extends to said distal end of said mixing element for being in fluid communication with said one or more third fluid exit openings.

7 . The system as claimed in claim 2 , wherein said one or more third fluid exit openings are located midway between said proximal and distal ends of said mixing element, and wherein said third fluid conduit of said mixing element extends to said midway location of said mixing element for being in fluid communication with said one or more third fluid exit openings.

8 . The system as claimed in claim 1 , wherein said one or more third fluid exit openings are located adjacent said proximal end of said mixing element, and wherein said third fluid inlet opening is in fluid communication with said one or more third fluid exit openings.

9 . The system as claimed in claim 2 , further comprising:
said inner surface of said outer wall of said spray tip housing comprising internal threads located adjacent said proximal end of said spray tip housing; and said distal end of said fluid connector having external threads that are configured to mesh with said internal threads of said spray tip housing for securing said distal end of said fluid connector with said proximal end of said spray tip housing.

10 . The system as claimed in claim 9 , wherein said first fluid channel of said fluid connector is aligned with a first lateral side of said mixing chamber, said second fluid channel of said fluid connector is aligned with a second lateral side of said mixing chamber, and said third fluid channel of said fluid connector is aligned with said third fluid inlet opening and said third fluid conduit of said mixing element.

11 . The system as claimed in claim 2 , further comprising:
a first chamber containing a first fluid having a first reactive component, wherein said first chamber is in fluid communication with said first fluid channel of said fluid connector; a second chamber containing a second fluid having a second reactive component that is reactive with said first reactive component, wherein said second chamber is in fluid communication with said second fluid channel of said fluid connector; and a third chamber containing a third fluid, wherein said third chamber is in fluid communication with said third fluid channel of said fluid connector; wherein said system is configured to direct said first and second fluids in series through said respective first and second fluid channels of said fluid connector and into said mixing chamber for forming a first mixture, and wherein said system is configured to direct said third fluid in series through said third fluid channel of said fluid connector, into said third fluid inlet opening of said mixing element, through said third fluid conduit of said mixing element, and laterally through said one or more third fluid exit openings of said mixing element for entering into said mixing chamber for being added into said first mixture of said first and second fluids to form a final mixture.

12 . The system as claimed in claim 11 , further comprising a dispensing cap disposed within said elongated conduit of said spray tip housing and secured to said distal end of said spray tip housing for opposing said distal end of said mixing element, wherein said dispensing cap comprises a dispensing opening that is in fluid communication with a distal end of said mixing chamber for expressing said final mixture of said first, second, and third fluids.

13 . A system for dispensing a biocompatible reactive formulation, the system comprising:
a first chamber containing a first fluid having a first reactive component; a second chamber containing a second fluid having a second reactive component that is reactive with said first reactive component; a third chamber containing a third fluid; a spray tip assembly that is configured for spraying a final mixture of said first, second and third fluids, said spray tip assembly comprising:
a spray tip housing having a proximal end, a distal end, an outer wall that extends from said proximal end to said distal end of said spray tip housing, and an elongated conduit surrounded by said outer wall that extends from said proximal end to said distal end of said spray tip housing;
a fluid connector secured to said proximal end of said spray tip housing and opposing a proximal end of a mixing element, said fluid connector incl

Assignees

• Ethicon Inc

Inventors

• Guo Jianxin
• Ghodbane Salim
• Dhanaraj Sridevi

Classifications

• A61K38/4833

  Thrombin (3.4.21.5) · CPC title

• A61K38/363

  Fibrinogen · CPC title

• A61J1/2093

  Containers having several compartments for products to be mixed · CPC title

• A61M11/06 Primary

  of the injector type · CPC title

• A61M5/2448

  comprising means for injection of two or more media, e.g. by mixing · CPC title