Dryer for a spray drying system

Patent metadata

Field	Value
Publication number	US-12539355-B2
Application number	US-202318467115-A
Country	US
Kind code	B2
Filing date	Sep 14, 2023
Priority date	Sep 15, 2022
Publication date	Feb 3, 2026
Grant date	Feb 3, 2026

Abstract

The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.

First claim

What is claimed is:

1 . A spray drying apparatus for use in a spray drying system that comprises a spray drying disposable and the spray drying apparatus, the spray drying disposable having a spray drying head, a plasma drying chamber and a gas outlet, wherein the spray drying head comprises a spray dry nozzle assembly that comprises a vortex generator; a plenum having a drying gas inlet in communication with a drying gas source, wherein the plenum supports the nozzle assembly; and a baffle plate forming a floor of the plenum having one or more drying gas jets; wherein the plasma drying chamber is attached to the spray drying head, and wherein the plasma drying chamber comprises a capture filter, the spay drying apparatus comprising:
A) the drying gas source that provides a drying gas from a Clean Dry Air (CDA) system, wherein when in use, the drying gas resides in the plenum with uniform air pressure, wherein, when in use, the one or more drying gas jets provide the drying gas to the plasma drying chamber; B) a plasma source that provides a plasma from one or more donors; C) a pressurized aerosol gas source that provides a pressurized aerosol gas from the CDA system; wherein when in use, the spray dry nozzle assembly is in fluid communication with the plasma source and the pressurized aerosol gas source, the pressurized aerosol gas atomizes the plasma entering the plasma drying chamber to thereby obtain atomized plasma droplets, atomized plasma droplets evaporate when coming into contact with the drying gas emitted from the one or more drying gas jets to thereby obtain dried plasma particles and humid air, and the capture filter captures the dried plasma particles and allows the humid air to pass; D) an exhaust port in communication with an exhaust line, wherein said gas outlet is attached to the exhaust port of the spray drying system during operation, wherein the humid air flows through the gas outlet; wherein the spray drying disposable acts as a barrier between the plasma and dryer or outside environment.

2 . The spray drying apparatus of claim 1 , wherein the drying gas source that provides the drying gas at a rate, when entering the nozzle, in a range from about 720 slpm to about 780 slmp.

3 . The spray drying apparatus of claim 1 , wherein the drying gas source provides the drying gas at a temperature in a range from about 110° C. to about 120° C.

4 . The spray drying apparatus of claim 1 , wherein the pressurized aerosol gas is provided at a rate in a range between from about 20 splm to about 60 slpm.

5 . The spray drying apparatus of claim 1 , wherein the pressurized aerosol gas is provided at a pressure in a range from about 180 kPa to about 260 kPa.

6 . The spray drying apparatus of claim 1 , wherein the vortex generator has gas pressure in a range from about 2.54×10 1 psig to about −2.24 psig.

7 . The spray drying apparatus of claim 1 , wherein the vortex generator has velocity in a range from about 2.00×10 1 m/s to about −3.75 ×10 2 m/s.

8 . The spray drying apparatus of claim 1 , wherein the plasma source that provides plasma when it enters the nozzle at a rate from about 6 mL/min to about 23 mL/min.

9 . The spray drying apparatus of claim 1 , an exhaust temperature ranges from about 62° C. to about 68° C.

10 . The spray drying apparatus of claim 1 , further including a closed loop wherein an exhaust temperature controls a plasma feed rate.

11 . The spray drying apparatus of claim 10 , wherein when the exhaust temperature increases, the plasma feed rate increases, and wherein when the exhaust temperature decreases, the plasma feed rate decreases.

12 . The spray drying apparatus of claim 10 , wherein the exhaust temperature has a range from about 62° C. to about 68° C. and plasma feed rates has a range from about 6 to about 23 mL/min.

13 . The spray drying apparatus of claim 1 , further comprising one or more filters in communication with the drying gas, the pressurized aerosol gas, humid air or combination thereof.

14 . A spray drying apparatus for use in a spray drying system that comprises a spray drying disposable and the spray drying apparatus, the spray drying disposable having a spray drying head, a plasma drying chamber and a gas outlet, wherein the spray drying head comprises a spray dry nozzle assembly that comprises a vortex generator; a plenum having a drying gas inlet in communication with a drying gas source, wherein the plenum supports the nozzle assembly; and a baffle plate forming a floor of the plenum having one or more drying gas jets and a baffle filter; wherein the plasma drying chamber is attached to the spray drying head, and wherein the plasma drying chamber comprises a capture filter, the spay drying apparatus comprising:
A) a housing having an inner chamber and a housing exhaust line having a housing exhaust valve; B) a leak detection line comprising a leak detection valve and a flow sensor; C) the drying gas source that provides a drying gas through a drying gas inlet from a Clean Dry Air (CDA) system, wherein when in use, the drying gas resides in the plenum with uniform air pressure, wherein, when in use, the one or more drying gas jets provide the drying gas to the plasma drying chamber; D) a plasma source that provides a plasma from one or more donors; said plasma source in communication with a scale; E) a pressurized aerosol gas source that provides a pressurized aerosol gas from the CDA system; wherein when in use, the spray dry nozzle assembly is in fluid communication with the plasma source and the pressurized aerosol gas source, the pressurized aerosol gas atomizes the plasma entering the plasma drying chamber to thereby obtain atomized plasma droplets, atomized plasma droplets evaporate when coming into contact with the drying gas emitted from the one or more drying gas jets to thereby obtain dried plasma particles and humid air, and the capture filter captures the dried plasma particles and allows the humid air to pass; F) an exhaust port in communication with a disposable exhaust line, wherein said gas outlet is attached to the exhaust port of the spray drying system during operation, wherein the humid air flows through the gas outlet, wherein the disposable exhaust line includes an exhaust valve; and G) at least one pressure sensing device at the inner chamber, the drying gas inlet or at the exhaust port; H) a computer system comprising at least one processor, at least one memory device, at least one data storage device, and at least one output device.

15 . The spray drying apparatus of claim 14 , further including the at least one pressure sensing device resides at the inner chamber and outside of the spray drying disposable wherein the pressure sensing device measures the pressure within the spray drying disposable.

16 . The spray drying apparatus of claim 15 , wherein the pressure sensing device detects a mechanical force and generates a proportional electrical output signal.

17 . A leak detection method using the spray drying apparatus of claim 14 , wherein the leak detection method determines an integrity of the spray drying disposable, the method comprising the steps of:
A) starting the spray drying apparatus; B) providing the drying gas at a temperature ranging between about 110° C. and about 120° C.; C) closing the exhaust valve in the disposable exhaust line, wherein one of the housing exhaust valve in the housing exhaust line or the leak detection valve in the leak detection line is closed; D) providing the pressurized aerosol gas or drying gas to the plasma drying chamber

Assignees

• Velico Medical Inc

Inventors

• Larocque Ryan
• Merritt William J

Classifications

• A61M1/0281 Primary

  Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing · CPC title

• A01N1/162

  Temperature processes, e.g. following predefined temperature changes over time · CPC title

• A01N1/146

  Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving · CPC title

• A01N1/142

  Apparatus · CPC title

• A61M2202/0415

  Plasma · CPC title