Nanomaterial compositions, synthesis, and assembly

Patent metadata

Field	Value
Publication number	US-12534468-B2
Application number	US-202318156306-A
Country	US
Kind code	B2
Filing date	Jan 18, 2023
Priority date	Nov 17, 2014
Publication date	Jan 27, 2026
Grant date	Jan 27, 2026

Abstract

Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII).

First claim

What is claimed:

1 . A composition comprising a compound of formula (I):

or a pharmaceutically acceptable salt or ester thereof wherein,
n is an integer of 0, 1, 2, 3, 4, 5 or 6;
R 1 is selected from an α-amino acid, a β-amino acid, an α-polypeptide,
a β-polypeptide,

j, k, m and p are each independently an integer of 0 to 20;
R x is aliphatic or H;
R y is H or

q, s and t are each independently an integer of 0 to 20;
R 2 is selected from H, CH 3 , or NHR z ;
R z is selected from H or aliphatic; and
wherein the compound is operative to self-assemble to form a nanotube.

2 . The composition of claim 1 , comprising a compound of formula (I)

wherein the compound of Formula (I) is Compound A,

3 . The composition of claim 1 , wherein
n is an integer of 1, 2, 3, 4, 5 or 6; j, k, m and p are each independently an integer of 1 to 20; and q, s and t are each independently an integer of 1 to 20.

4 . The composition of claim 1 , wherein R 1 is selected from an α-amino acid comprising a covalent bond between an α-amino group and (CH 2 ) n , a β-amino acid comprising a covalent bond between a β-amino group and (CH 2 ) n , an α-polypeptide comprising a covalent bond between an α-amino group and (CH 2 ) n , a β-polypeptide comprising a covalent bond between a β-amino group and (CH 2 ) n ,

5 . The composition of claim 2 , wherein R 1 is an α-amino acid comprising a covalent bond between an α-amino group and (CH 2 ) n or a β-amino acid comprising a covalent bond between a β-amino group and (CH 2 ) n .

6 . The composition of claim 5 , wherein R 1 in Formula (I) is

7 . The composition of claim 1 , wherein the compounds are provided in the form of a nanotube.

8 . The composition of claim 7 , wherein said nanotube further comprises one or more therapeutic agents.

9 . The composition of claim 8 , wherein said therapeutic agent comprises a nucleic acid, a peptide or a molecule.

10 . The composition of claim 8 , further comprising matrilin.

11 . The composition of claim 10 , wherein said matrilin comprises Matrilin-3.

12 . The composition of claim 8 , further comprising a bioactive agent.

13 . The composition of claim 12 , wherein the bioactive agent comprises a bone morphogenetic protein (BMP), vascular endothelial growth factor (VEGF), connective tissue growth factor (CTGF), osteoprotegerin, growth differentiation factor (GDF), cartilage-derived morphogenetic protein (CDMP), LIM mineralization protein (LMP), transforming growth factor beta (TGF-β), antibiotic, immunosuppressive agent, or a combination thereof.

14 . The composition of claim 10 , further comprising an immunosuppressive agent.

15 . The composition of claim 14 , wherein the immunosuppressive agent is selected from the group consisting of steroids, cyclosporine, cyclosporine analogs, cyclophosphamide, methylprednisolone, prednisone, azathioprine, FK-506, and er-15-deoxyspergualin.

Assignees

• Rhode Island Hospital

Inventors

• Chen Qian
• Yu Hongchuan
• Chen Yupeng

Classifications

• A61L2400/12

  Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title

• A61L2300/414

  Growth factors · CPC title

• A61L2300/406

  Antibiotics · CPC title

• A61L2300/252

  Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines · CPC title

• A61F2/30756

  Cartilage endoprostheses (A61F2/3603 takes precedence) · CPC title