T-type calcium channel blocker
US-2022363667-A1 · Nov 17, 2022 · US
US12534451B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12534451-B2 |
| Application number | US-202017598163-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 26, 2020 |
| Priority date | Mar 27, 2019 |
| Publication date | Jan 27, 2026 |
| Grant date | Jan 27, 2026 |
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The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment.
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What is claimed is: 1 . A compound selected from the group consisting of: 2 . A pharmaceutical composition comprising a therapeutically effective amount of at least one compound of claim 1 and a pharmaceutically acceptable carrier. 3 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 4 . The compound of claim 1 , wherein the compound is: 5 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 6 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 7 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 8 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 9 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 10 . The compound of claim 1 , wherein the compound is: 11 . The compound of claim 1 , wherein the compound is: 12 . The compound of claim 1 , wherein the compound is: 13 . The compound of claim 1 , wherein the compound is: 14 . The compound of claim 1 , wherein the compound is: 15 . The compound of claim 1 , wherein the compound is: 16 . The compound of claim 1 , wherein the compound is: 17 . The compound of claim 1 , wherein the compound is: 18 . The compound of claim 1 , wherein the compound is:
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