Small molecule modulators of PanK

US12534451B2 · US · B2

Patent metadata
FieldValue
Publication numberUS-12534451-B2
Application numberUS-202017598163-A
CountryUS
Kind codeB2
Filing dateMar 26, 2020
Priority dateMar 27, 2019
Publication dateJan 27, 2026
Grant dateJan 27, 2026

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  1. Title

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  2. Abstract

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  3. Assignees and inventors

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  4. Key dates

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  5. First independent claim

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  6. CPC / IPC classifications

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  7. Citations and related patents

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Abstract

Official abstract text for this publication.

The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment.

First claim

Opening claim text (preview).

What is claimed is: 1 . A compound selected from the group consisting of: 2 . A pharmaceutical composition comprising a therapeutically effective amount of at least one compound of claim 1 and a pharmaceutically acceptable carrier. 3 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 4 . The compound of claim 1 , wherein the compound is: 5 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 6 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 7 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 8 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 9 . The compound of claim 1 , wherein the compound is selected from the group consisting of: 10 . The compound of claim 1 , wherein the compound is: 11 . The compound of claim 1 , wherein the compound is: 12 . The compound of claim 1 , wherein the compound is: 13 . The compound of claim 1 , wherein the compound is: 14 . The compound of claim 1 , wherein the compound is: 15 . The compound of claim 1 , wherein the compound is: 16 . The compound of claim 1 , wherein the compound is: 17 . The compound of claim 1 , wherein the compound is: 18 . The compound of claim 1 , wherein the compound is:

Assignees

Inventors

Classifications

  • Ortho-condensed systems · CPC title

  • Ortho-condensed systems · CPC title

  • Ortho-condensed systems · CPC title

  • directly linked by a ring-member-to-ring-member bond · CPC title

  • directly linked by a ring-member-to-ring-member bond · CPC title

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Frequently asked questions

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What does patent US12534451B2 cover?
The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment.
Who is the assignee on this patent?
St Jude Childrens Res Hospital, St Jude Childrens Res Hospital Inc
What technology area does this patent fall under?
Primary CPC classification C07D403/04. Mapped technology areas include Chemistry & Metallurgy.
When was this patent published?
Publication date Tue Jan 27 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
What related patents are in patentsdb?
We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).