Dried plasma system

Patent metadata

Field	Value
Publication number	US-12533604-B2
Application number	US-202519215132-A
Country	US
Kind code	B2
Filing date	May 21, 2025
Priority date	Sep 15, 2022
Publication date	Jan 27, 2026
Grant date	Jan 27, 2026

Abstract

The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.

First claim

What is claimed is:

1 . A spray dried plasma system having a unit of spray dried plasma that is obtained from a donor, the system comprises:
a) a container having the unit of spray dried plasma, provided to an intended recipient or a third party acting on behalf of the intended recipient at a first time point at which the intended recipient is not in need of a plasma transfusion; and b) a reconstitution solution, provided to a provider, the intended recipient or the third party; wherein the container having the unit of spray dried plasma is stored at a location controlled by the intended recipient or the third party for a storage period.

2 . The spray dried plasma system of claim 1 , wherein after the storage period, at a second time point at which the intended recipient is in need of a plasma transfusion; the provider combining an amount of the reconstitution solution with the spray dried plasma, to thereby obtain a reconstituted previously spray dried plasma; and transfusing the reconstituted previously spray dried plasma into the intended recipient.

3 . The spray dried plasma system of claim 1 , wherein when the reconstitution solution is combined with the unit of spray dried plasma in the container to thereby obtain a reconstituted previously spray dried plasma, a level of one or more plasma proteins of the reconstituted previously spray dried plasma is within about 25% of a level of the one or more plasma proteins in reconstituted spray dried plasma before storage.

4 . The spray dried plasma system of claim 1 , wherein the dried plasma has a residual moisture in a range from about 0.5% to about 2.5%.

5 . The spray dried plasma system of claim 1 , wherein the donor is the intended recipient, to thereby provide for an autologous plasma transfusion.

6 . The spray dried plasma system of claim 1 , wherein the intended recipient is at increased risk for a plasma transfusion.

7 . The spray dried plasma system of claim 1 , wherein the donor is a third-party donor.

8 . The spray dried plasma system of claim 1 , wherein when the reconstitution solution is combined with the unit of spray dried plasma in the container to thereby obtain a reconstituted previously spray dried plasma, the spray dried plasma reconstitutes in a time period ranging between about 2 minutes and about 5 minutes, as measured from first touch by a user to completed reconstitution with no visible clumps.

9 . The spray dried plasma system of claim 8 , wherein the reconstituted previously spray dried plasma is stable for transfusion, for up to about 8 hours.

10 . The spray dried plasma system of claim 8 , wherein the reconstituted previously spray dried plasma has a pH ranging from about 6.5 to about 7.8.

11 . The spray dried plasma system of claim 1 , wherein the reconstitution solution comprises SWFI.

12 . The spray dried plasma system of claim 1 , wherein the storage period ranges from about 1 day to about 4 years.

13 . A spray dried plasma system having spray dried plasma from a donor, said spray dried plasma is obtained using a spray drying disposable device having a spray drying head and a drying chamber, for use in a spray drying apparatus having a drying gas source providing a drying gas and a pressurized aerosol gas source providing a pressurized aerosol gas, a plasma source providing the plasma; wherein the spray dried plasma system comprises:
a) a container having spray drying plasma from the donor, wherein the container is obtained from a spray drying disposable device, wherein the spray drying disposable device comprises:
i) the spray drying head, wherein the spray drying head comprises:
(1) a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source, wherein the pressurized aerosol gas flows in a vortex pattern, wherein, when in use, the pressurized aerosol gas atomizes the plasma entering the drying chamber to obtain atomized plasma droplets;

ii) the drying chamber, attached to the spray drying head, wherein atomized plasma droplets evaporate in the drying gas emitted from the spray drying head, wherein, when in use, the drying chamber receives dried plasma particles and humid air; wherein the drying chamber is configured to house the spray dried plasma, to thereby obtain the container having a unit of spray dried plasma.

14 . The spray dried plasma system of claim 13 , wherein the system further comprises a reconstitution solution, wherein the reconstitution solution is combined with the spray dried plasma in the container to thereby obtain a reconstituted previously spray dried plasma.

15 . The spray dried plasma system of claim 13 , wherein the container having a unit of spray dried plasma is provided to an intended recipient that is not in need of a plasma transfusion at a first time point, wherein the container having the unit of spray dried plasma is stored for future use by the intended recipient.

16 . The spray dried plasma system of claim 15 , wherein the container having the unit of spray dried plasma is stored at a location controlled by the intended recipient or on behalf of the intended recipient for a storage period.

17 . The spray dried plasma system of claim 15 , wherein after the storage period at a second time point when the intended recipient is in need of a plasma transfusion, a provider combines an amount of the reconstitution solution with the spray dried plasma, to thereby obtain a reconstituted previously spray dried plasma, and transfuses the reconstituted previously spray dried plasma into the intended recipient.

18 . The spray dried plasma system of claim 14 , wherein when the reconstitution solution is combined with the unit of spray dried plasma in the container to thereby obtain a reconstituted previously spray dried plasma, a level of one or more plasma proteins of the reconstituted previously spray dried plasma is within about 25% of a level of the one or more plasma proteins in reconstituted spray dried plasma before storage.

19 . The spray dried plasma system of claim 13 , wherein the dried plasma has a residual moisture in a range from about 0.5% to about 2.5%.

20 . The spray dried plasma system of claim 15 , wherein the donor is the intended recipient, to thereby provide for an autologous plasma transfusion.

21 . The spray dried plasma system of claim 13 , wherein the donor is a third-party donor.

22 . The spray dried plasma system of claim 15 , wherein the intended recipient is at increased risk for a plasma transfusion.

23 . The spray dried plasma system of claim 22 , wherein the intended recipient that is at the increased future risk for a plasma transfusion comprises a soldier, a policeman, a fire fighter, or an adventurer.

24 . The spray dried plasma system of claim 17 , wherein the provider is a health care provider comprising a doctor, nurse or first responder.

25 . The spray dried plasma system of claim 14 , wherein when the reconstitution solution is combined with the unit of spray dried plasma in the container to thereby obtain a reconstituted previously spray dried plasma, the spray dried plasma reconstitutes in a time period ranging between about 2 minutes and about 5 minutes, as measured from first touch by a user to completed reconstitution with no visible clumps.

26 . The spray dried plasma system of claim 14 , wherein the reconstituted previously spray dried plasma is sta

Assignees

• Velico Medical Inc

Inventors

• Andrews Robert R
• Snyder Herman E
• Merritt William J
• Ordway Evan P
• Strohl Clair
• Meehan Richard
• Popovsky Mark A
• Buckley Lisa A
• Sohn Jihae

Classifications

• F26B25/06

  Chambers, containers, or receptacles {(large containers having means for heating, cooling, aerating or other conditioning of contents B65D88/74)} · CPC title

• F26B21/004

  Mechanical Engineering · mapped topic

• F26B3/12

  in the form of a spray {, i.e. sprayed or dispersed emulsions or suspensions (spray drying of solutions B01D1/18)} · CPC title

• C12N5/0634

  Cells from the blood or the immune system · CPC title

• B01D1/18 Primary

  to obtain dry solids (B01D1/24 takes precedence) · CPC title