Systems and methods for background signal reduction in biosensors

Patent metadata

Field	Value
Publication number	US-12533084-B2
Application number	US-202117370860-A
Country	US
Kind code	B2
Filing date	Jul 8, 2021
Priority date	Jul 10, 2020
Publication date	Jan 27, 2026
Grant date	Jan 27, 2026

Abstract

A method of operating an analyte device includes: receiving an analyte signal measured from an analyte sensor device having a sensor tail; generating adjusted analyte data based on the analyte signal, the generating the adjusted analyte data including reducing a background signal in the analyte signal in accordance with an offset signal; computing an analyte value based on the adjusted analyte data; and displaying the analyte value on a display device.

First claim

What is claimed is:

1 . A method of operating an analyte sensor device in a manner so as to attempt to reduce a background signal in an analyte reading of the analyte sensor device, resulting in mitigation of an erroneous detection of the analyte reading and further resulting in improved control of a drug delivery pump, said method comprising:
determine a drug dosage that is delivered to a user of the analyte sensor device via the drug delivery pump; deliver the drug dosage to the user via the drug delivery pump; receiving a first analyte signal and a second analyte signal measured by the analyte sensor device, which includes an analyte sensor, wherein the analyte sensor includes an in vivo portion; computing one or more metrics of agreement between the first analyte signal and the second analyte signal; comparing the one or more metrics of agreement against a threshold; in response to a determination that the one or more metrics of agreement exceed the threshold:
computing an orthogonal fit between the first analyte signal and the second analyte signal;
computing an offset based on the orthogonal fit;
correcting at least one of the first analyte signal and the second analyte signal based on the offset in real-time;
generating adjusted analyte data based on the corrected analyte signal in real-time, wherein generating the adjusted analyte data includes reducing the background signal in the corrected analyte signal;
computing an analyte value based on the adjusted analyte data; and
displaying the analyte value on a display device; and
in response to computing the analyte value, which is based on the adjusted analyte data in which the background signal is reduced, modifying the drug dosage that is delivered to the user via the drug delivery pump and subsequently delivering the modified drug dosage to the user via the drug delivery pump, such that reduction of the background signal facilitates an improved accuracy of the analyte value, which is used to control the drug delivery pump.

2 . The method of claim 1 , further comprising:
displaying a trend indicator; displaying an analyte level; or generating an alert.

3 . The method of claim 1 , wherein generating the adjusted analyte data further includes:
subtracting an offset signal from the corrected analyte signal to generate an offset corrected signal; calculating a plurality of sensitivities from the offset corrected signal, each sensitivity corresponding to a reference point of a plurality of analyte reference points; computing a median of the sensitivities over a time window; calculating the adjusted analyte data based on the offset corrected signal and the median of the sensitivities; and pairing the adjusted analyte data with the reference points.

4 . The method of claim 3 , wherein the offset signal is computed from a global time-varying background offset based on an elapsed time since activation of the analyte sensor device to compute the offset corrected signal.

5 . The method of claim 3 , wherein the offset signal is a time-invariant offset.

6 . The method of claim 3 , wherein the analyte sensor device comprises:
a first working electrode on the in vivo portion of the analyte sensor, the first working electrode having a first sensitivity; and a second working electrode on the in vivo portion of the analyte sensors, the second working electrode having a second sensitivity lower than the first sensitivity.

7 . The method of claim 6 , wherein the first working electrode has a first active region having a first quantity of a catalyst disposed thereon, and wherein the second working electrode has a second active region having a second quantity of the catalyst disposed thereon, the second active region having a surface area smaller than that of the first active region.

8 . The method of claim 7 , wherein generating the adjusted analyte data further includes:
detecting the first analyte signal from the first working electrode; detecting the second analyte signal from the second working electrode; computing a difference between the first analyte signal and the second analyte signal; and computing the adjusted analyte data based on the difference between the first analyte signal and the second analyte signal.

9 . The method of claim 8 , further comprising computing an individual background offset based on the first analyte signal, the second analyte signal, and the difference between the first analyte signal and the second analyte signal, wherein the offset signal is calculated based on the individual background offset.

10 . The method of claim 6 , wherein the second working electrode is configured to measure an individual background current, and wherein the offset signal is calculated based on the individual background current.

11 . The method of claim 1 , further comprising:
applying a temperature correction on the first analyte signal or the second analyte signal based on a temperature from a temperature sensor of the analyte sensor device.

12 . The method of claim 1 , wherein the in vivo portion of the analyte sensor extends from a body of the analyte sensor device and comprises:
a first working electrode, the first working electrode having a first sensing layer at a first position along a length of the in vivo portion; and a second working electrode, the second working electrode having a second sensing layer at a second position along the length of the in vivo portion, the second position being proximal to the first position.

13 . The method of claim 12 , further comprising:
detecting the first analyte signal from the first working electrode; and detecting the second analyte signal from the second working electrode.

14 . The method of claim 13 , wherein the offset is a fixed offset based on the orthogonal fit.

15 . The method of claim 13 , wherein the offset is a time-varying offset based on the orthogonal fit.

16 . The method of claim 1 , further comprising detecting a system fault of the analyte sensor device when the one or more metrics of agreement exceed the threshold, wherein the system fault is late sensor attenuation (LSA).

17 . An analyte sensor device that is configured to operate in a manner so as to attempt to reduce a background signal in an analyte reading of the analyte sensor device, resulting in mitigation of an erroneous detection of the analyte reading and further resulting in improved control of a drug delivery pump, said analyte sensor device comprising:
a plurality of communication circuitry; and a plurality of processing circuitry having memory storing instructions that, when executed by the processing circuitry, cause the processing circuitry to:
determine a drug dosage that is delivered to a user of the analyte sensor device via the drug delivery pump;
deliver the drug dosage to the user via the drug delivery pump;
receive a first analyte signal and a second analyte signal measured from the analyte sensor device, which includes an in vivo portion, the first analyte signal and the second analyte signal being received via the communication circuitry;
compute one or more metrics of agreement between the first analyte signal and the second analyte signal;
compare the one or more metrics of agreement against a threshold;
in response to a determination that the one or more metrics of agreement exceed the threshold:
compute an orthogonal fit between the first analyte signal and the second analyte signal;
compute an offset based on the orthogonal fit;
correct at least one of the first analyte signal and the second

Assignees

• Abbott Diabetes Care Inc

Inventors

• Ou Junli
• Cho Hyun
• Chen Ting
• Budiman Erwin S
• Oja Stephen
• Chen Kuan-Chou

Classifications

• A61B2560/0247

  for compensation or correction of the measured physiological value · CPC title

• A61B5/14546

  for measuring analytes not otherwise provided for, e.g. ions, cytochromes · CPC title

• A61B5/14532 Primary

  for measuring glucose, e.g. by tissue impedance measurement · CPC title

• A61B5/7221

  Determining signal validity, reliability or quality (preventing, reducing or removing noise induced by motion artefacts A61B5/7207; noise originating from a therapeutic or surgical apparatus A61B5/7217) · CPC title

• A61B5/4839

  combined with drug delivery · CPC title