Automatic analysis device

Patent metadata

Field	Value
Publication number	US-12529709-B2
Application number	US-202017622908-A
Country	US
Kind code	B2
Filing date	Jul 2, 2020
Priority date	Jul 4, 2019
Publication date	Jan 20, 2026
Grant date	Jan 20, 2026

Abstract

The automatic analysis device includes an evaporative concentration unit configured to perform a concentration process of evaporating an extract solution obtained by extracting a component to be analyzed in a sample to concentrate the component to be analyzed; an analysis unit configured to analyze the component to be analyzed of the sample; and a control unit configured to control operations of the analysis unit and the evaporative concentration unit. The control unit determines whether to perform an evaporative concentration process on a component to be analyzed in the sample, and controls the evaporative concentration unit to concentrate a component to be analyzed in a sample which is determined to be subjected to an evaporative concentration process. The sample to be subjected to the evaporative concentration process is stored, and the control unit selects whether to perform the evaporative concentration on each sample or not based on stored content.

First claim

The invention claimed is:

1 . An automatic analysis device, comprising:
an evaporative concentration unit configured to perform a concentration process of evaporating an extract solution obtained by extracting a component to be analyzed in a sample to concentrate the component to be analyzed; an analysis unit configured to analyze the component to be analyzed of the sample; and a control unit configured to control operations of the analysis unit and the evaporative concentration unit, wherein the control unit is configured to determine whether to perform an evaporative concentration process on a component to be analyzed in the sample, and control the evaporative concentration unit to concentrate a component to be analyzed in a sample which is determined to be subjected to an evaporative concentration process, the extract solution contains an internal standard substance, a diluent containing a standard substance for concentration ratio calculation is added to the extract solution subjected to the concentration process performed by the evaporative concentration unit, the analysis unit is configured to detect signal amounts of the component to be analyzed, the internal standard substance, and the standard substance for concentration ratio calculation, and the control unit is configured to calculate a concentration ratio of the extract solution based on reference data for determination and the detected signal amounts, the reference data for determination being signal amounts of the internal standard substance and the standard substance for concentration ratio calculation, which are acquired in advance.

2 . The automatic analysis device according to claim 1 ,
wherein the evaporative concentration unit includes: a heating unit configured to heat and evaporate the extract solution; and an exhaust unit configured to aspirate vapor generated by the heating unit.

3 . The automatic analysis device according to claim 2 ,
wherein the evaporative concentration unit further includes a standby unit configured to hold a sample which is determined not to be subjected to an evaporative concentration by the control unit on standby.

4 . The automatic analysis device according to claim 2 ,
wherein the exhaust unit is configured to move between a first position separated by a predetermined distance from the heating unit and a second position in close contact with the heating unit, and wherein the control unit is configured to dispose the exhaust unit on the first position when the evaporative concentration is not performed, and move the exhaust unit to the second position when the evaporative concentration is to be performed.

5 . The automatic analysis device according to claim 2 ,
wherein the extract solution is accommodated in a container, and wherein the heating unit includes a container receiving unit which is configured to receiver the container, and an ejector pin which is configured to push up the container accommodated in the container receiving unit from below.

6 . The automatic analysis device according to claim 2 , further comprising:
a movable unit, wherein the extract solution is accommodated in a container, and the movable unit is configured to move the heating unit between a non-heating position not in contact with the container in which the extract solution in the container is not heated, and a heating position in contact with the container.

7 . The automatic analysis device according to claim 2 ,
wherein the heating unit is disposed in an evaporative concentration area and includes an opening/closing unit configured to open and close the evaporative concentration area, and the exhaust unit is configured to evacuate an inside of the evaporative concentration area.

8 . The automatic analysis device according to claim 1 , further comprising:
a display unit, wherein the control unit is configured to determine whether the evaporative concentration process is sufficient based on the concentration ratio of the extract solution, and when the evaporative concentration process is determined to be insufficient, an alarm indicating that the evaporative concentration process is insufficient is displayed on the display unit.

9 . The automatic analysis device according to claim 2 ,
wherein a sample to be subjected to an evaporative concentration process and a sample not to be subjected to the evaporative concentration process are mixed and are continuously processed at regular intervals.

Assignees

• Hitachi High Tech Corp

Inventors

• Ebihara Daisuke
• Matsuoka Shinya
• Sakazume Taku

Classifications

• G01N2035/00376

  Conductive heating, e.g. heated plates · CPC title

• G01N2030/025

  Gas chromatography · CPC title

• G01N35/025

  having a carousel or turntable for reaction cells or cuvettes · CPC title

• G01N35/0098

  involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation (magnetic particles used in immunoassays G01N33/54326; magnetic separation in general B03C) · CPC title

• G01N35/00594

  Quality control, including calibration or testing of components of the analyser · CPC title