Analysis system

Patent metadata

Field	Value
Publication number	US-12529640-B2
Application number	US-201917781657-A
Country	US
Kind code	B2
Filing date	Dec 25, 2019
Priority date	Dec 25, 2019
Publication date	Jan 20, 2026
Grant date	Jan 20, 2026

Abstract

A field flow fractionator (FFF device) 1 classifies particles in a liquid sample by applying a field to a liquid sample supplied from a sample injection device 5 . A detector 6 detects the particles in the liquid sample classified by the FFF device 1 . A bypass flow path 8 supplies the liquid sample from the sample injection device 5 to the detector 6 without via the FFF device 1 . A rotary valve (flow path switching unit) 4 switches a flow path to guide the liquid sample from the sample injection device 5 to the FFF device 1 or a bypass flow path 8 . The bypass flow path 8 is provided with a concentration adjusting device 9 for adjusting the concentration of the liquid sample from the sample injection device 5 . In a case where a sample with the same quantity as the sample supplied to the FFF device 1 is supplied to the bypass flow path 8 at the time of analysis, the sample is diluted by the concentration adjusting device 9 such that a detection signal from the detector 6 falls within a dynamic range.

First claim

The invention claimed is:

1 . An analysis system comprising:
a mobile phase supply section configured to supply a mobile phase; a sample injection device configured to inject a sample into the mobile phase supplied from the mobile phase supply section to produce a liquid sample; a field flow fractionator configured to classify particles in the liquid sample by applying a field to the liquid sample supplied from the sample injection device; a detector configured to detect the particles in the liquid sample classified by the field flow fractionator; a bypass flow path configured to directly fluidically connect the sample injection device and the detector; and a flow path switching unit configured to switch a flow path to guide the liquid sample from the sample injection device to the field flow fractionator or the bypass flow path, wherein the sample injection device is provided upstream of the flow path switching unit, wherein the bypass flow path is provided with a concentration adjusting device for adjusting a concentration of the liquid sample supplied from the sample injection device, wherein a quantity of the sample included in the liquid sample supplied to the field flow fractionator is the same as a quantity of the sample included in the liquid sample supplied to the bypass flow path, and wherein, prior to supplying the liquid sample to the detector by the bypass flow path, the concentration adjusting device dilutes the quantity of the sample included in the liquid sample supplied to the bypass flow path such that a first detection signal from the detector falls within a dynamic range of the detector.

2 . The analysis system as recited in claim 1 ,
wherein the concentration adjusting device dilutes the liquid sample supplied to the detector from the bypass flow path by increasing a quantity of mobile phase included within the liquid sample supplied to the detector from the bypass flow path.

3 . The analysis system as recited in claim 1 , further comprising:
an operation unit configured to calculate a recovery rate of the particles in the liquid sample based on: a second detection signal from the detector in a case where the liquid sample is supplied to the detector from the field flow fractionator and a field is applied; and the first detection signal from the detector in a case where the liquid sample is supplied to the detector from the bypass flow path.

4 . The analysis system as recited in claim 3 ,
wherein the concentration adjusting device includes a buffer section having a capacity that allows the liquid sample supplied to the detector from the bypass flow path to be diluted such that the first detection signal from the detector falls within the dynamic range of the detector.

5 . The analysis system as recited in claim 4 ,
wherein the capacity of the buffer section is equal to or substantially equal to a capacity of a flow path included in the field flow fractionator.

6 . The analysis system as recited in claim 4 ,
wherein the capacity of the buffer section allows the liquid sample supplied to the detector from the bypass flow path to be diluted such that a peak intensity of the first detection signal from the detector is equal to or substantially equal to the second detection signal from the detector.

Assignees

• Shimadzu Corp

Inventors

• Aoki Kengo

Classifications

• G01N1/10

  in the liquid or fluent state {(burettes, pipettes B01L3/02; sampling of ground water E02D1/06; metering by volume of fluids or fluent solid material G01F11/00, G01F13/00)} · CPC title

• G01N15/02

  Investigating particle size or size distribution (by measuring osmotic pressure G01N7/10; investigating sedimentation of particle suspensions G01N15/04; investigating individual particles G01N15/10) · CPC title

• G01N2015/0053

  in liquids, e.g. trouble · CPC title

• G01N15/1459

  the analysis being performed on a sample stream · CPC title

• G01N30/20

  using a sampling valve · CPC title