Composition for preventing or treating neuropathic pain, containing syringaresinol

Patent metadata

Field	Value
Publication number	US-12521364-B2
Application number	US-202017762955-A
Country	US
Kind code	B2
Filing date	Sep 25, 2020
Priority date	Sep 25, 2019
Publication date	Jan 13, 2026
Grant date	Jan 13, 2026

Abstract

The present invention relates to a composition for preventing, ameliorating, or treating neuropathic pain, comprising syringaresinol or a pharmaceutically acceptable salt thereof as an active ingredient. The composition of the present invention may be administered to a subject for which administration of an anticancer agent is scheduled or to which an anticancer agent has been administered, or to a subject which has suffered peripheral nerve damage, to thereby prevent, ameliorate, or treat neuropathic pain.

First claim

The invention claimed is:

1 . A method for treatment of neuropathic pain, the method comprising administering to a subject with a pharmaceutical composition comprising as an active ingredient syringaresinol or a pharmaceutically acceptable salt thereof, wherein the neuropathic pain is allodynia caused by an anticancer drug or a pain caused by peripheral nerve injury.

2 . The method of claim 1 , wherein the allodynia is at least one selected from the group consisting of cold allodynia and mechanical allodynia.

3 . The method of claim 1 , wherein the anticancer drug is at least one anticancer drug selected from the group consisting of taxane- and platinum-based anticancer drugs.

4 . The method of claim 3 , wherein the anticancer drug is at least one selected from the group consisting of paclitaxel and oxaliplatin.

5 . The method of claim 1 , wherein the composition is orally administered at a concentration of 5 mg/kg to 100 mg/kg.

6 . The method of claim 1 , wherein the method further comprises administering to a subject a composition containing an anticancer drug as an active ingredient.

7 . The method of claim 6 , wherein the routes and frequencies of administration of the pharmaceutical composition comprising as an active ingredient syringaresinol or a pharmaceutically acceptable salt thereof and the composition containing an anticancer drug as an active ingredient are independent, respectively.

Assignees

• Univ Industry Cooperation Group Kyung Hee Univ

Inventors

• Kim Sun Kwang
• Jang Dae Sik
• Cho Ik Hyun
• Lee Zee Hwan
• Chae Hyeonkyeong
• Choi Jonghee

Classifications

• A61P25/02 Primary

  for peripheral neuropathies · CPC title

• A23V2250/30

  Other Organic compounds · CPC title

• A23V2200/322

  having an effect on the health of the nervous system or on mental function · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L33/10

  using additives (addition of substantially indigestible substances A23L33/21) · CPC title