Cranial implant devices, systems, and related methods

Patent metadata

Field	Value
Publication number	US-12521244-B2
Application number	US-202017642408-A
Country	US
Kind code	B2
Filing date	Sep 11, 2020
Priority date	Sep 13, 2019
Publication date	Jan 13, 2026
Grant date	Jan 13, 2026

Abstract

Provided herein are cranial implant devices that include at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials. The cranial implant devices are structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject and typically includes a substantially anatomically-compatible shape. In addition, the cranial implant devices permit transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the cranial opening of the subject. Other aspects are directed to various related systems and methods of obtaining diagnostic information from, and/or administering therapy to, a subject.

First claim

What is claimed is:

1 . A cranial implant device, comprising:
at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials; one or more transparent, sonolucent, and/or acoustically inert materials disposed at least proximal to a first and/or a second side of the acoustic, optical, and/or photoacoustic lens element;
wherein the cranial implant device is structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject,
wherein the cranial implant device comprises a substantially anatomically-compatible shape, and
wherein the cranial implant device permits transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the at least one cranial opening of the subject; and
at least one cover positioned over the at least one cranial opening of the subject when the cranial implant device is subgalealy implanted within, beneath, and/or over the at least one cranial opening of the subject, which cover is structured as an acoustic lens.

2 . The cranial implant device of claim 1 , wherein the acoustic, optical, and/or photoacoustic lens element comprises one or more wave-guides.

3 . A cranial implant device, comprising:
at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials; and one or more transparent, sonolucent, and/or acoustically inert materials disposed at least proximal to a first and/or a second side of the acoustic, optical, and/or photoacoustic lens element,
wherein the cranial implant device is structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject,
wherein the cranial implant device comprises a substantially anatomically-compatible shape,
wherein the cranial implant device permits transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the at least one cranial opening of the subject, and
wherein the acoustic, optical, and/or photoacoustic lens element comprises at least one metamaterial having a negative refractive index and at least one other material having a subwavelength microstructure.

4 . A cranial implant device, comprising:
at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials; and one or more transparent, sonolucent, and/or acoustically inert materials disposed at least proximal to a first and/or a second side of the acoustic, optical, and/or photoacoustic lens element,
wherein the cranial implant device is structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject,
wherein the cranial implant device comprises a substantially anatomically-compatible shape,
wherein the cranial implant device permits transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the at least one cranial opening of the subject, and
wherein the acoustic, optical, and/or photoacoustic lens element comprises at least one substantially flat diverging lens comprising at least two different materials, wherein at least a first material transmits sound at a higher speed than a tissue of the subject, and wherein at least a second material transmits sound at a lower speed than the tissue of the subject.

5 . A cranial implant device, comprising:
at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials; and one or more transparent, sonolucent, and/or acoustically inert materials disposed at least proximal to a first and/or a second side of the acoustic, optical, and/or photoacoustic lens element,
wherein the cranial implant device is structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject,
wherein the cranial implant device comprises a substantially anatomically-compatible shape,
wherein the cranial implant device permits transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the at least one cranial opening of the subject, and
wherein the acoustic, optical, and/or photoacoustic lens element comprises at least one diverging compound concave lens comprising at least two different materials, wherein at least a first material transmits sound at a higher speed than at least a second material, and wherein the second material is positioned closer to a scalp of the subject than the first material when the cranial implant device is subgalealy implanted within, beneath, and/or over the at least one cranial opening of the subject.

6 . A cranial implant device, comprising:
at least one acoustic, optical, and/or photoacoustic lens element comprising one or more electromagnetically translucent, electromagnetically transparent, sonolucent, and/or acoustically active materials; and one or more transparent, sonolucent, and/or acoustically inert materials disposed at least proximal to a first and/or a second side of the acoustic, optical, and/or photoacoustic lens element,
wherein the cranial implant device is structured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject,
wherein the cranial implant device comprises a substantially anatomically-compatible shape,
wherein the cranial implant device permits transcranial therapeutic ultrasound, transcranial diagnostic ultrasound, photoacoustic imaging, electromagnetic wave diagnostic imaging, and/or electromagnetic wave therapeutic intervention of intracranial matter of the subject via the acoustic, optical, and/or photoacoustic lens element when the cranial implant device is subgalealy implanted within, beneath, and/or over the at least one cranial opening of the subject, and
wherein the acoustic, optical, and/or photoacoustic lens element comprises at least one diverging compound convex lens comprising at least two different materials, wherein at least a first material transmits sound at a lower speed than at least a second material, and wherein the second material is positioned closer to a scalp of the subject than the first material when the cranial implant device is subgalely implanted within, beneath, and/or over the at least one cranial opening of the subject.

Assignees

• Univ Johns Hopkins

Inventors

• Gordon Chad
• Belzberg Micah
• Manbachi Amir

Classifications

• A61B8/0808

  for diagnosis of the brain · CPC title

• A61B5/6864

  Burr holes · CPC title

• A61B5/0095

  by applying light and detecting acoustic waves, i.e. photoacoustic measurements · CPC title

• A61F2/481

  Acoustic or audible means · CPC title

• A61F2/482

  Electrical means · CPC title