System and methods for delivering a test bolus for medical imaging

Patent metadata

Field	Value
Publication number	US-12514974-B2
Application number	US-202017606532-A
Country	US
Kind code	B2
Filing date	Jun 2, 2020
Priority date	Jun 4, 2019
Publication date	Jan 6, 2026
Grant date	Jan 6, 2026

Abstract

Provided is a method for delivering a medical fluid. The method includes administering a test injection at a preselected total volumetric flowrate for a preselected duration. The preselected total volumetric flowrate of the test injection is substantially maintained throughout the preselected duration of the test injection and is substantially similar to an anticipated total volumetric flowrate of the fluid to be administered during at least a first phase of a diagnostic injection protocol. The method further includes performing a test scan of one or more regions of interest of the patient, determining a patient response function for the patient for each of the one or more regions of interest based, at least in part, on the enhancement output, and determining a diagnostic injection protocol based at least in part upon the patient response function from each of the one or more regions of interest.

First claim

The invention claimed is:

1 . A method of administering a medical fluid comprising a contrast agent to a patient in connection with a diagnostic imaging procedure, the method comprising:
(a) administering a test injection into the patient at a preselected total volumetric flowrate for a preselected duration, wherein the test injection is comprised of a volumetric amount of a contrast agent and, optionally, a volumetric amount of a flush fluid, wherein the preselected total volumetric flowrate of the test injection is substantially maintained throughout the preselected duration of the test injection, wherein the test injection is comprised of a plurality of phases including at least a first phase in which the fluid administered consists entirely of the flush fluid and a second phase following the first phase in which the fluid administered comprises both the contrast agent and the flush fluid, and wherein the preselected total volumetric flowrate is substantially similar to an anticipated total volumetric flowrate of the fluid to be administered during at least a first phase of a diagnostic injection protocol; (b) performing a test scan of one or more regions of interest of the patient as the test injection propagates therethrough to obtain scan data resulting therefrom; (c) determining from the scan data an enhancement output from each of the one or more regions of interest at one or more points in time as a result of the propagation of the test injection therethrough; (d) determining a patient response function for the patient for each of the one or more regions of interest based, at least in part, on the enhancement output; (e) determining the diagnostic injection protocol based at least in part upon the patient response function from at least one of the one or more regions of interest, wherein a first phase of the diagnostic injection protocol comprises administering the fluid at a total volumetric flowrate that is substantially similar to the preselected total volumetric flowrate of the test injection; and administering a diagnostic injection into the patient according to the diagnostic injection protocol.

2 . The method of claim 1 , wherein a total duration of any contrast-containing phases of the test injection is no more than 80% of a total duration of any contrast-containing phases of the diagnostic injection.

3 . The method of claim 1 , wherein administering the diagnostic injection into the patient comprises:
delivering, during a first duration of the diagnostic injection protocol, a volume of the medical fluid at a total volumetric flowrate, wherein the total volumetric flowrate is substantially similar to the preselected total volumetric flowrate of the test injection.

4 . The method of claim 1 , wherein the one or more regions of interest include at least two regions of interest.

5 . The method of claim 1 , wherein the fluid administered during the second phase of the test injection further comprises the flush fluid.

6 . The method of claim 1 , wherein the fluid administered during the second phase of the test injection comprises at least 50% by volume of the contrast agent.

7 . The method of claim 1 , wherein the test injection comprises, among the plurality of phases, a third phase that follows the second phase, wherein a fluid administered during the third phase of the test injection consists entirely of the flush fluid.

8 . The method of claim 1 , wherein a final phase of the plurality of phases of the test injection comprises administering a fluid that consists entirely of the flush fluid.

9 . The method of claim 1 , wherein the preselected total volumetric flowrate of the test injection is between about 0.5 mL/s and about 10 mL/s.

10 . The method of claim 1 , wherein the preselected total volumetric flowrate of the test injection is between about 1 mL/s and about 7 mL/s.

11 . The method of claim 1 , wherein the preselected duration of the test injection is between about 5 and about 50 seconds.

12 . The method of claim 1 , wherein the preselected duration of the test injection is between about 5 and about 20 seconds.

13 . The method of claim 1 , wherein a timing to perform the test scan is determined based upon at least one of the following: information about a medical imager system to be used to perform the test scan, the one or more regions of interest, and movement capability of the medical imager system.

14 . The method of claim 13 , wherein the test injection is administered by an injector and the test scan is performed by the medical imager system.

15 . The method of claim 14 , further comprising transferring at least one of the scan data and the enhancement output from the medical imager system to the injector through a data capture method comprising taking, using a digital camera, a photograph of a user interface of the medical imager system, wherein the user interface displays at least one of the scan data and the enhancement output, processing the photograph to extract portions of the at least one of the scan data and the enhancement output, and transferring the extracted portions of the at least one of the scan data and the enhancement output to the injector.

16 . A fluid delivery system, comprising:
a fluid administration device adapted to deliver to a patient a test injection and a diagnostic injection, wherein each injection comprises a volumetric amount of a contrast agent and, optionally, a volumetric amount of a flush fluid; and a processor and non-transitory machine-readable storage medium, wherein the non-transitory machine-readable storage medium comprises programming instructions that, when executed by the processor, enable the fluid administration device to:
administer the test injection at a preselected total volumetric flowrate for a preselected duration, wherein the preselected total volumetric flowrate is substantially maintained throughout the preselected duration of the test injection, wherein the test injection is comprised of a plurality of phases including at least a first phase in which the fluid administered consists entirely of the flush fluid and a second phase following the first phase in which the fluid administered comprises both the contrast agent and the flush fluid, and wherein the preselected total volumetric flowrate is substantially similar to an anticipated total volumetric flowrate of at least a first phase of the diagnostic injection;
receive scan data from a test scan of one or more regions of interest of the patient, wherein the test scan is performed as the test injection propagates through the patient;
determine from the scan data an enhancement output from each of the one or more regions of interest at one or more points in time as a result of the propagation of the test injection through the patient;
determine a patient response function for the patient for each of the one or more regions of interest based, at least in part, on the enhancement output;
determine a diagnostic injection protocol, based at least in part, upon the patient response function from at least one of the one or more regions of interest; and
administer a diagnostic injection into the patient according to the diagnostic injection protocol.

17 . A system for patient imaging, comprising:
a fluid administration device adapted to deliver to a patient a test injection and a diagnostic injection, wherein each injection comprises a volumetric amount of a contrast agent and, optionally, a volumetric amount of a flush fluid; a medical imager system adapted to perform an imaging scan of the patient; and a

Assignees

• Bayer Healthcare Llc

Inventors

• Uber Iii Arthur
• Barone William

Classifications

• A61M2205/502

  User interfaces, e.g. screens or keyboards · CPC title

• A61M2005/14208

  with a programmable infusion control system, characterised by the infusion program · CPC title

• A61M5/16877

  Adjusting flow; Devices for setting a flow rate · CPC title

• A61M5/007 Primary

  for contrast media · CPC title