Methods and kits for removing calculus using a metal ion and bicarbonate

Patent metadata

Field	Value
Publication number	US-12514792-B2
Application number	US-201716342824-A
Country	US
Kind code	B2
Filing date	Sep 5, 2017
Priority date	Oct 20, 2016
Publication date	Jan 6, 2026
Grant date	Jan 6, 2026

Abstract

Methods and kits for removing calculus from a tooth, wherein the method can include applying a component A to the tooth, wherein component A comprises: a metal ion selected from the group of lithium ion, magnesium ion, calcium ion, a precursor thereto, and a combination thereof; and an aprotic base having a pKb in water of greater than 15.4, or a precursor thereto; applying a component B to the tooth, wherein component B comprises a bicarbonate ion or a precursor thereto; wherein components A and B are applied simultaneously or sequentially to the tooth, thereby generating a gas to soften and/or loosen at least part of the calculus on the tooth; and removing at least a part of the calculus from the tooth.

First claim

What is claimed is:

1 . A method of removing calculus from a tooth, the method comprising:
applying a component A to the tooth,
component A is selected from calcium chloride and magnesium chloride, wherein component A is applied as an aqueous solution at a concentration of 3M or a saturated solution;
applying a component B to the tooth,
component B is a source of bicarbonate ion,
wherein component B is applied as an aqueous solution at a concentration of 1 M, wherein component A and component B are applied simultaneously or sequentially to the tooth, and wherein component A and component B generate gas when combined to soften and/or loosen at least part of the calculus on the tooth; and
removing at least a part of the calculus from the tooth.

2 . The method of claim 1 , wherein component A is applied before or after component B is applied.

3 . The method of claim 2 , wherein component A is applied for a period of less than 1 hour before applying component B.

4 . The method of claim 2 , wherein component B is applied for a period of less than 1 hour before applying component A.

5 . The method of claim 1 , wherein component A is a saturated aqueous solution.

6 . The method of claim 1 , wherein component A is an aqueous solution at a concentration of 3 M.

7 . The method of claim 1 , wherein the source of bicarbonate ion comprises a carbonate and an acid.

8 . The method of claim 1 , wherein component B is sodium bicarbonate, potassium bicarbonate, or a combination thereof.

9 . A kit of parts for use in a method of removing calculus from a tooth according to claim 1 , the kit comprising:
a component A selected from calcium chloride and magnesium chloride, component A provided as an aqueous solution at a concentration of 3M or a saturated solution; a component B is a source of bicarbonate ion, component B provided as an aqueous solution at a concentration of 1M; and a set of instructions directing a user to:
apply component A and component B to the tooth simultaneously or sequentially, and
remove at least a part of the calculus from the tooth.

10 . The method of claim 1 component A is magnesium chloride and component B is sodium bicarbonate, potassium bicarbonate, or a combination thereof.

11 . The method of claim 10 , wherein component A is an aqueous solution at a concentration of 3M.

12 . The method of claim 10 , wherein component A is a saturated aqueous solution.

13 . The method of claim 1 , component A is calcium chloride and component B is sodium bicarbonate, potassium bicarbonate, or a combination thereof.

14 . The method of claim 13 , wherein component A is an aqueous solution at a concentration of 3M.

15 . The method of claim 13 , wherein component A is a saturated aqueous solution.

Assignees

• Solventum Intellectual Properties Company

Inventors

• Kohler Riedi Petra L
• Hajime Evan Koon Lun Yuuji
• Swanson Steven P
• Cao Chuntao
• Haeberlein Ingo R
• Gong Tao

Classifications

• A61K33/14

  Alkali metal chlorides; Alkaline earth metal chlorides · CPC title

• A61K33/06

  Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay} · CPC title

• A61K33/10

  Carbonates; Bicarbonates · CPC title

• A61Q11/00 Primary

  Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses · CPC title

• A61K2800/88

  Two- or multipart kits · CPC title