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Carbon monoxide dehydrogenase having excellent oxygen resistance and enzyme activity, and use thereof
US12509664B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12509664-B2 |
| Application number | US-202018006563-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 27, 2020 |
| Priority date | Jul 24, 2020 |
| Publication date | Dec 30, 2025 |
| Grant date | Dec 30, 2025 |
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- Title
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Abstract
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Provided is a carbon monoxide (CO) dehydrogenase with increased oxygen resistance and/or enzyme activity, specifically, a mutant CO dehydrogenase with increased oxygen resistance and/or enzyme activity by mutating amino acid residues. The CO dehydrogenase may detoxify toxic carbon monoxide at room temperature and pressure by easily oxidizing carbon monoxide and converting the same into carbon dioxide, and may effectively oxidize carbon monoxide even in gas including oxygen. Furthermore, since it is possible to remove carbon monoxide, which is emitted in large quantities in industries such as petrochemical and steel industries, cigarette burning, household cooking, various boilers, and combustion, through cigarette filters, air purifiers, intake filters in household cooking equipment, gas boilers, etc. the CO dehydrogenase may be utilized in various ways.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A carbon monoxide (CO) dehydrogenase with increased oxygen resistance and/or enzyme activity, wherein the CO dehydrogenase is a protein encoded by a polynucleotide having a nucleotide sequence according to one of SEQ ID NOs: 24, 26, 30, 35-38, or 40-43. 2 . The CO dehydrogenase of claim 1 , wherein the oxygen resistance is increased 1 to 200 times compared to a wild type CO dehydrogenase. 3 . The CO dehydrogenase of claim 1 , wherein the enzyme activity is increased 1 to 200 times compared to the wild type CO dehydrogenase. 4 . A polynucleotide encoding the CO dehydrogenase of claim 1 . 5 . A vector expressing the CO dehydrogenase of claim 1 . 6 . A microorganism expressing the CO dehydrogenase of claim 1 . 7 . A method of preparing the CO dehydrogenase comprising culturing the microorganism expressing the polynucleotide encoding the CO dehydrogenase of claim 1 . 8 . A method of removing carbon monoxide comprising contacting carbon monoxide with the CO dehydrogenase of claim 1 . 9 . A method of preparing carbon dioxide comprising contacting carbon monoxide with the CO dehydrogenase of claim 1 . 10 . A device for removing carbon monoxide comprising the CO dehydrogenase of claim 1 . 11 . A filter comprising the CO dehydrogenase of claim 1 .
Assignees
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Classifications
Carbon-monoxide dehydrogenase (cytochrome b-561)(1.2.2.4) · CPC title
- C12N15/70Primary
Vectors or expression systems specially adapted for E. coli · CPC title
Carbon monoxide · CPC title
Biological processes · CPC title
by biological methods, i.e. processes using enzymes or microorganisms · CPC title
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- What does patent US12509664B2 cover?
- Provided is a carbon monoxide (CO) dehydrogenase with increased oxygen resistance and/or enzyme activity, specifically, a mutant CO dehydrogenase with increased oxygen resistance and/or enzyme activity by mutating amino acid residues. The CO dehydrogenase may detoxify toxic carbon monoxide at room temperature and pressure by easily oxidizing carbon monoxide and converting the same into carbon d…
- Who is the assignee on this patent?
- Ulsan Nat Inst Science & Tech Unist
- What technology area does this patent fall under?
- Primary CPC classification C12N15/70. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).