Biological material adhesion inhibitor

Patent metadata

Field	Value
Publication number	US-12509608-B2
Application number	US-202117904470-A
Country	US
Kind code	B2
Filing date	Feb 18, 2021
Priority date	Feb 19, 2020
Publication date	Dec 30, 2025
Grant date	Dec 30, 2025

Abstract

Provided are a composition for forming a coating film, a coating film and a substrate having the coating film, which have excellent compatibility with biological substances, as well as a method for producing the same. A composition for forming a coating film having the ability to inhibit adhesion of biological substances, the composition comprising a copolymer and a solvent, wherein the copolymer is obtained by subjecting a monomer mixture to polymerization, wherein the monomer mixture comprises compounds represented by the following formulae (1), (2), and (3):wherein R1 to R6, n, and m are as defined in the Description and Claims,wherein the compound represented by the formula (3) above is contained in a predetermined amount in the monomer mixture, a coating film obtained from the composition, and a substrate having the coating film as well as a method for producing the same.

First claim

The invention claimed is:

1 . A composition for forming a coating film having the ability to inhibit adhesion of biological substances, the composition comprising a copolymer and a solvent, wherein the copolymer is obtained by subjecting a monomer mixture to polymerization, the monomer mixture comprising
a compound represented by the following formula (1-3):

wherein and n represents an integer of 3 to 6,
a compound represented by the following formula (2):

wherein R 3 represents a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms, and R 4 represents a cationic monovalent organic group, and
a compound represented by the following formula (3):

wherein each R 5 independently represents a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms, R 6 represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted with a halogen atom, and m represents an integer of 1 to 30,
wherein the amount of the compound represented by the formula (3) is 2 to 40% by mass, based on the mass of the monomer mixture.

2 . A coating film having the ability to inhibit adhesion of biological substances, which is a coating film comprising the composition for forming the coating film according to claim 1 .

3 . A substrate having the ability to inhibit adhesion of biological substances, which has the coating film according to claim 2 on the surface thereof.

4 . The substrate having the ability to inhibit adhesion of biological substances according to claim 3 , which is for use in cell culture.

5 . A method for producing a substrate having the ability to inhibit adhesion of biological substances, comprising the steps of: applying the composition for forming the coating film according to claim 1 to a substrate; and then drying it.

6 . A cell culture container having the surface coated with a copolymer, wherein the copolymer is obtained by subjecting a monomer mixture to polymerization, the monomer mixture comprising
a compound represented by the following formula (1-3):

wherein n represents an integer of 3 to 6,
a compound represented by the following formula (2):

wherein R 3 represents a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms, and R 4 represents a cationic monovalent organic group, and
a compound represented by the following formula (3):

wherein each R 5 independently represents a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms, Re represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted with a halogen atom, and m represents an integer of 1 to 30,
wherein the amount of the compound represented by the formula (3) is 2 to 40% by mass, based on the mass of the monomer mixture.

Assignees

• Nissan Chemical Corp

Inventors

• HIROI Miya
• Shoji Takeaki
• Hiroi Yoshiomi
• Abe Natsuki
• Ueda Yuki

Classifications

• C09D5/1668

  Vinyl-type polymers · CPC title

• C08F230/02

  containing phosphorus · CPC title

• C12M23/20

  Material Coatings (immunocoatings C12M25/00) · CPC title

• C09D133/04

  Homopolymers or copolymers of esters {(C09D143/04 takes precedence)} · CPC title

• C09D5/16

  Antifouling paints; Underwater paints · CPC title