Neurosteroid compounds and methods for their preparation and use in treating central nervous system disorders
US-11542296-B2 · Jan 3, 2023 · US
Neurosteroid compounds and methods for their preparation and use in treating central nervous system disorders
US12509487B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12509487-B2 |
| Application number | US-202218091431-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 30, 2022 |
| Priority date | Apr 23, 2018 |
| Publication date | Dec 30, 2025 |
| Grant date | Dec 30, 2025 |
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- Title
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- Abstract
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Abstract
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Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily synthesized and have improved pharmaceutical properties, including water solubility, compared to known neurosteroids.
First claim
Opening claim text (preview).
What is claimed is: 1 . A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof. 2 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 3 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 4 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 5 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 6 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 7 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 8 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 9 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 10 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof. 11 . The compound of claim 1 , wherein the compound is: or a pharmaceutically acceptable salt thereof; or the compound is: or a pharmaceutically acceptable salt thereof. 12 . A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. 13 . The pharmaceutical composition of claim 12 , wherein said pharmaceutically acceptable carrier is a cream, gel, liposome, nanoparticle, ointment, polymeric micelle, protein, or a microsphere.
Assignees
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Classifications
containing unsubstituted amino radicals · CPC title
not substituted in position 16 · CPC title
Antiepileptics; Anticonvulsants · CPC title
with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group · CPC title
Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom · CPC title
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Frequently asked questions
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- What does patent US12509487B2 cover?
- Described herein is the chemical structure of neurosteroid derivative compounds, methods of synthesizing the derivatives, and their uses in treating disorders, including those of the central nervous system. These compounds are readily synthesized and have improved pharmaceutical properties, including water solubility, compared to known neurosteroids.
- Who is the assignee on this patent?
- Texas A & M Univ Sys
- What technology area does this patent fall under?
- Primary CPC classification C07J43/003. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 30 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).