Apparatus and process for the automated chemical synthesis of compounds

Patent metadata

Field	Value
Publication number	US-12508566-B2
Application number	US-202217944462-A
Country	US
Kind code	B2
Filing date	Sep 14, 2022
Priority date	Jan 12, 2016
Publication date	Dec 30, 2025
Grant date	Dec 30, 2025

Abstract

Provided is an process for the automated synthesis of at least one chemical compound including providing at least one substrate in at least one solvent in the at least one reaction container; automatically passing the at least one substrate through at least one first compartment of the at least one cartridge once or several times and collecting a formed substrate-reagent intermediate product in the at least one reaction container prior to passing the substrate-reagent intermediate product into a subsequent compartment; automatically passing the substrate-reagent intermediate product through at least one second compartment once or several times and collecting a formed reaction product prior to passing the reaction product into a subsequent compartment; automatically passing the reaction product through at least one third compartment for purifying the product once or several times and collecting a purified product in the at least one reaction container.

First claim

The invention claimed is:

1 . A process for the automated synthesis of chemical compounds, comprising:
providing an apparatus comprising: (a) at least one solvent container for storing solvent system(s) used for at least one compartment of at least one cartridge, the at least one solvent container comprising at least one solvent reservoir, the at least one solvent reservoir having an inlet and an outlet, (b) at least one reaction container for providing compound(s) to be fed into at least one of the compartments of the at least one cartridge and/or collecting reaction product(s) from at least one of the compartments of the at least one cartridge, the at least one reaction container having an inlet and an outlet; (c) at least one first valve for selecting a liquid source from the at least one solvent reservoir or the at least one reaction container, the at least one first valve having an inlet connected to the outlet of the at least one solvent reservoir and the outlet of the at least one reaction container, and an outlet connected to a pump inlet; (d) at least one pump comprising a first pump comprising the pump inlet for receiving liquid from the outlet of the first valve and a pump outlet connected to an inlet of at least one second valve for directing the liquid received from the at least one first valve to the at least one second valve either directly or through optional pump(s) of the at least one pump; (e) the at least one second valve for directing the liquid received from the at least one pump to an inlet of at least one compartment of the at least one cartridge or the inlet of the at least one reaction container, the at least one second valve having the inlet for receiving the liquid from the at least one pump, and an outlet connected to the inlet of the at least one compartment of the at least one cartridge and the inlet of the at least one reaction container; (f) at least one cartridge comprising:
(i) at least one first compartment for providing at least one first reagent for the chemical synthesis of the at least one compound, the at least one first compartment having the inlet connected to the outlet of the at least one second valve, and an outlet connected to the at least one reaction container for passing a formed substrate-reagent intermediate product into the at least one reaction container;
(ii) at least one second compartment for providing at least one second reagent for the chemical synthesis of the at least one compound, the at least one second compartment having an inlet for receiving the substrate-reagent intermediate product from the outlet of the at least one reaction container, and an outlet connected to the inlet of the at least one reaction container for passing a formed reaction product into the at least one reaction container, and
(iii) at least one third compartment for purifying the at least one synthesized compound, the at least one third compartment having an inlet connected to the outlet of the reaction container for receiving the formed reaction product from the outlet of the first reaction container, and an outlet connected to the inlet of the at least one reaction container for passing the purified product into the at least one reaction container, at least one heating unit for heating at least one of the first compartment or the second compartment, at least one stirring unit for stirring the at least one reaction container, and a controller programmed to operate and control the at least one first valve, the at least one second valve, the pump, the at least one heating unit, and the at least one stirring unit; providing at least one substrate in at least one solvent in the at least one reaction container; controlling the at least one first valve, the at least one second valve and the pump with the controller to automatically pass the at least one substrate through the at least one first compartment comprising the first reagent as at least one immobilized reagent once or several times, controlling the temperature of the at least one substrate with the controller to form a substrate-reagent intermediate product, and controlling the at least one first valve, the at least one second valve and the pump with the controller to collect the formed substrate-reagent intermediate product prior to passing the substrate-reagent intermediate product into a subsequent compartment; controlling the at least one first valve, the at least one second valve and the pump with the controller to automatically pass the substrate-reagent intermediate product through at least one second compartment comprising at least one catalyst as the second reagent once or several times, controlling the temperature of the substrate-reagent intermediate product with the controller to form a reaction product, and controlling the at least one first valve, the at least one second valve and the pump with the controller to collect the formed reaction product prior to passing the reaction product into a subsequent compartment; and controlling the at least one first valve, the at least one second valve and the pump with the controller to automatically pass the reaction product through at least one third compartment comprising at least one ion exchange support for purifying the reaction product once or several times and collect the purified product.

2 . The process according to claim 1 , wherein the process further comprises controlling the at least one first valve, the at least one second valve and the pump with the controller to automatically pass the reaction product formed in the at least one second compartment through at least one compartment C comprising at least one scavenging matrix for removing the at least one catalyst from the reaction product and collect a second reaction product prior to passing the second reaction product into the at least one third compartment.

3 . The process according to claim 1 for the automated synthesis of a chemical compound comprising at least one N-heterocyclic structure, wherein the substrate comprises
at least one aldehyde of the general formulae (IIa) R 8 —CHO or at least one ketone of the general formulae (IIb) R 8 R 9 CO, wherein R 8 and R 9 are selected from a group comprising alkyl, alkenyl, cycloalkyl, cycloalkenyl, —COOR 12 (R 12 being alkyl), aryl, heteroaryl, which are in each case non-substituted or substituted; or where R 8 and R 9 are joined to form an alkyl ring system,
which can be interrupted by one or multiple oxygen atoms, sulphur atoms, substituted and/or unsubstituted nitrogen atoms and/or by one or multiple groups of the type —C(O)O—, —OC(O)—, —C(O)—, —NHC(O)O—, —OC(O)NH— and/or —OC(O)O,
wherein the at least one first compartment comprises at least one immobilized Sn-containing reagent of general formulae (Ia) or general formulae (Ib), wherein general formulae (Ia) is R 1 R 2 R 3 Sn—CH 2 —X—(CR 4 R 5 ) n —(CR 6 R 7 ) m —N═Y-carrier and general formulae (Ib) is R 1 R 2 R 3 Sn—CHXR 10 —(CR 4 R 5 ) n —(CR 6 R 7 ) m —N═Y-carrier, wherein R 1 , R 2 , R 3 , R 10 are selected from a group comprising alkyl, wherein R 1 , R 2 , R 3 can be the same or different;
X is selected from a group comprising O, protected N, S;
R 4 , R 5 , R 6 , R 7 are selected from a group comprising H, alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, wherein R 4 , R 5 , R 6 , R 7 can be the same or different; and/or
at least one of R 4 , R 5 and at least one of R 6 , R 7 together form an alkyl or (hetero-) aryl ring system, or
at least two of R 4 and R 5 or at least two of R 6 , R 7 together form a alkyl or aryl spirocyclic ring system,
which can be interrupted by one or multiple oxygen atoms, sulphur atoms, substituted and/or unsubstituted nitrogen atoms and/or by one or multiple groups of the type —C(O)O—, —OC(O)—, —C(O)—, —NHC(O)O—, —OC(O)NH— and/or —OC(O)O,
n, m=1-6,
Y═P(R 11 ) 2 , wherein R 11 can

Assignees

• Eth Zuerich

Inventors

• Bode Jeffrey William
• Wanner Benedikt Matthias
• Chen Kuang-Yen
• Pattabiraman Vijaya
• Nichols Paula Louise

Classifications

• C07D295/027

  containing only one hetero ring · CPC title

• C07D213/36

  Radicals substituted by singly-bound nitrogen atoms (nitro radicals C07D213/26) · CPC title

• B01J2219/00191

  Control algorithm · CPC title

• B01J47/024

  where the ion-exchangers are in a removable cartridge · CPC title

• B01J20/26

  Synthetic macromolecular compounds · CPC title