Particle containing lipid nanoparticles and method for producing same

Patent metadata

Field	Value
Publication number	US-12508223-B2
Application number	US-202117998895-A
Country	US
Kind code	B2
Filing date	May 18, 2021
Priority date	May 20, 2020
Publication date	Dec 30, 2025
Grant date	Dec 30, 2025

Abstract

A particle includes at least one or more kinds of substrate and lipid nanoparticles. The lipid nanoparticles are dispersed in the substrate and contain a physiologically active substance. The lipid nanoparticles are one or more kinds selected from liposomes, lipid emulsions, and solid lipid nanoparticles. A corresponding powder inhalant contains the particle. A production method for the particle includes granulating and drying, in which a suspension containing the substrate and the lipid nanoparticles are granulated and dried in a gas medium.

First claim

The invention claimed is:

1 . A production method for a particle, the particle comprising:
at least one or more kinds of a substrate, and at least one or more kinds of lipid nanoparticles, wherein the lipid nanoparticles are dispersed in the substrate, wherein the lipid nanoparticles are selected from the group consisting of liposomes, lipid emulsions and solid lipid nanoparticles, and contain a physiologically active substance; wherein the physiologically active substance has a property of irreversibly changing physiological activity by heating, cooling, or external stress; wherein the production method comprises granulating and drying, in which a suspension containing the substrate and the lipid nanoparticles is granulated and dried in a gas medium; wherein the granulating and drying includes droplet discharging, in which vibration is imparted to the suspension containing the substrate and the lipid nanoparticles accommodated in a liquid column resonance liquid chamber, to form a stationary wave due to liquid column resonance, and the suspension is discharged as droplets from a discharge port formed in an amplitude direction of the stationary wave in an antinode region of the stationary wave, and particle forming, in which the discharged suspension is dried to form particles.

2 . The production method according to claim 1 , wherein the substrate contains a water soluble material.

3 . The production method according to claim 1 , wherein the substrate includes at least one sugar selected from the group consisting of: monosaccharides, disaccharides, polysaccharides, sugar alcohols, and derivatives thereof.

4 . The production method according to claim 1 , wherein the substrate includes at least one sugar selected from the group consisting of: lactose and mannitol.

5 . The production method according to claim 1 , wherein the volume average particle size of the particle comprising the at least one or more kinds of the substrate and the at least one or more kinds of lipid nanoparticles is 0.5 μm or more and 100 μm or less.

6 . The production method according to claim 5 , wherein the volume average particle size of the particle comprising the at least one or more kinds of the substrate and the at least one or more kinds of lipid nanoparticles is 1 μm or more and 25 μm or less.

Assignees

• Moritani Tatsuru
• Shizuoka Prefectural Univ Corporation
• Ricoh Co Ltd

Inventors

• Moritani Tatsuru
• Onoue Satomi
• Sato Hideyuki

Classifications

• A61K38/13

  Cyclosporins · CPC title

• A61K9/5123

  Organic compounds, e.g. fats, sugars · CPC title

• A61K9/5089

  Processes · CPC title

• A61K9/1617

  Organic compounds, e.g. phospholipids, fats · CPC title

• A61K9/0075 Primary

  for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles · CPC title