Auxetic stents for managing venous stenosis

Patent metadata

Field	Value
Publication number	US-12508139-B2
Application number	US-202318523755-A
Country	US
Kind code	B2
Filing date	Nov 29, 2023
Priority date	Jan 11, 2019
Publication date	Dec 30, 2025
Grant date	Dec 30, 2025

Abstract

Stents useable for treating venous stenosis are disclosed. In embodiments, a stent is configured to be auxetic, expanding axially as it is expanded radially, to prevent the imposition of tension on portions of a blood vessel adjacent to the stented portion of the blood vessel, and thereby prevent a narrowing of the adjacent portions and improving luminal gain. The stent may include one or more cross members that are deformable axially, to allow the axial length of the stent to be adjusted while maintaining a constant diameter, and further to allow the stent to be curved to conform to vessel curvature.

First claim

The invention claimed is:

1 . An apparatus for use in a vein, comprising:
a first member and a second member, each of the first member and the second member comprising a single flexible junction, each flexible junction dividing each respective member into a first segment with a first segment end and a second segment with a second segment end, the first segment and the second segment of each member extending from its respective flexible junction, and each respective first and second segment ends distal from each respective flexible junction; a cross member with a first end connected to the first segment of the first member and a second end, distal from the first end, connected to the first segment of the second member, wherein the cross member is connected to each first segment closer to, but spaced from, each first segment's first segment end than from each member's flexible junction; wherein the first member, the second member, and the cross member define a cell, a first joining member connected to the second segment of the first member closer to, but spaced from, the first member's flexible junction than to the second segment end of the first member, extending from the first member in a first direction outside the cell; and a second joining member connected to the second segment of the second member closer to, but spaced from, the second member's flexible junction than to the second segment end of the second member, extending from the second member in a second direction outside the cell and opposing the first direction, wherein the cross member, the first joining member, and the second joining member are each deformable along a longitudinal axis to permit longitudinal expansion and compression of the apparatus.

2 . The apparatus of claim 1 , wherein:
the first joining member comprises a third end that is distal from the first member; the second joining member comprises a fourth end that is distal from the second member; each first segment end is configured to flexibly join to a second segment end of a first adjacent apparatus; and the third end is configured to join to a fifth end of a second adjacent apparatus.

3 . The apparatus of claim 1 , wherein the apparatus is made from a shape memory material that can be plastically deformed at temperatures below a predetermined temperature, and will return to a non-deformed shape at temperatures above the predetermined temperature.

4 . The apparatus of claim 3 , wherein the apparatus is made from a nickel- titanium alloy.

5 . The apparatus of claim 1 , wherein the first joining member and the second joining member each respectively attach to the first and second members in an acute bend.

6 . The apparatus of claim 1 , wherein each flexible junction forms a bend directed toward an interior of the cell.

7 . The apparatus of claim 1 , wherein the cross-member forms a first acute angle with the first member and a second acute angle with the second member, both the first and second acute angles located in an interior of the cell.

8 . A stent, comprising:
a plurality of cells, each cell comprising:
a first member and a second member, each of the first member and the second member comprising a single flexible junction, each flexible junction dividing each respective member into a first segment with a first segment end and a second segment with a second segment end, the first segment and the second segment of each member extending from its respective flexible junction, and each respective first and second segment ends distal from each respective flexible junction;
a cross member with a first end connected to the first segment of the first member proximate to the first segment end of the first member, and a second end, distal from the first end, connected to the first segment of the second member proximate to, but spaced from, the first segment end of the second member, wherein the cross member is connected to each first segment distal from each member's flexible junction;
a first joining member connected to the second segment of the first member proximate to, but spaced from, the first member's flexible junction and distal from the second segment end of the first member, extending from the first member in a first direction outside the cell; and a second joining member connected to the second segment of the second member proximate to, but spaced from, the second member's flexible junction and distal from the second segment end of the second member, extending from the second member in a second direction outside the cell and opposing the first direction, wherein the plurality of cells are interconnected to each other via one or more of each cell's first segment ends, second segment ends, first joining member, and/or second joining member to permit longitudinal expansion and compression of the stent.

9 . The stent of claim 8 , wherein the plurality of cells are interconnected to form a tubular structure.

10 . The stent of claim 9 , wherein:
the plurality of cells comprises a first set of cells, a second set of cells, and a third set of cells; each of the first, second, and third sets of cells comprises a tubular structure, the first set of cells is axially attached to a first end of the second set of cells, and the third set of cells is axially attached to a second end of the second set of cells.

11 . The stent of claim 9 , wherein the stent has a first end and a second end, and one of the ends comprises a plurality of barbs.

12 . The stent of claim 9 , wherein the stent comprises a plurality of barbs disposed axially along the stent.

13 . The stent of claim 9 , wherein each of the plurality of cells is made from a shape memory material that can be plastically deformed at temperatures below a predetermined temperature, and will return to a non-deformed shape at temperatures above the predetermined temperature.

14 . The stent of claim 13 , wherein the stent is made from a nickel-titanium alloy.

15 . The stent of claim 8 , wherein each first joining member and second joining member of each cell is connected to its respective first member and second member in an acute bend.

Assignees

• Univ Oregon Health & Science

Inventors

• Al-Hakim Ramsey
• Farsad Khashayar
• Kaufman John
• Bonsignore Craig

Classifications

• A61F2220/0016

  with sharp anchoring protrusions, e.g. barbs, pins, spikes · CPC title

• A61F2210/0019

  operated at only one temperature whilst inside or touching the human body, e.g. constrained in a non-operative shape during surgery, another temperature only occurring before the operation · CPC title

• A61F2002/91575

  connected peak to trough · CPC title

• A61F2250/0048

  differing in mechanical expandability, e.g. in mechanical, self- or balloon expandability · CPC title

• A61F2002/8483

  Barbs · CPC title