3D Printable Hydrogel Materials
US-2017327813-A1 · Nov 16, 2017 · US
Elastomeric nanocomposite hydrogels
US12503559B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12503559-B2 |
| Application number | US-201816218051-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 12, 2018 |
| Priority date | Aug 21, 2017 |
| Publication date | Dec 23, 2025 |
| Grant date | Dec 23, 2025 |
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- Title
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Abstract
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An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products.
First claim
Opening claim text (preview).
Having described the invention, we claim: 1 . A composition comprising: an elastomeric nanocomposite hybrid hydrogel that includes first natural polymer macromers covalently crosslinked with second natural polymer macromers and the first natural polymer macromers are ionically crosslinked with a plurality of inorganic nanoparticles, wherein the plurality of inorganic nanoparticles ionically form reversible physical crosslinks with carboxylic groups of the first natural polymer macromers; the elastomeric nanocomposite hybrid hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products; wherein the first natural polymer macromers are acrylated and/or methacrylated polysaccharides, which are optionally oxidized and the second natural polymer macromers include an acrylate group and/or methacrylate group; and wherein the acrylate and/or methacrylate groups of the first natural polymer macromers react with the acrylate and/or methacrylate groups of the second natural polymer macromers polymers to form the covalent crosslinks. 2 . The composition of claim 1 , wherein the elasticity of the hydrogel is substantially maintained during degradation. 3 . The composition of claim 1 , wherein the first natural polymer macromers are photocrosslinked with the second natural polymer macromers. 4 . The composition of claim 1 , wherein the first natural polymer macromers comprise acrylated and/or methacrylated alginates, which are optionally oxidized. 5 . The composition of claim 1 , wherein the second natural polymer macromers comprise acrylated and/or methacrylated gelatin. 6 . The composition of claim 1 , wherein the first natural polymer macromers comprise acrylated and/or methacrylated alginates, which are optionally oxidized, and the second natural polymer macromers comprise acrylated and/or methacrylated gelatin and wherein methacrylate and/or acrylate groups of the optionally oxidized acrylated and/or methacrylated alginates react with methacrylate and/or acrylate groups of the acrylated and/or methacrylated gelatin to form the covalent crosslinks. 7 . The composition of claim 1 , wherein the inorganic nanoparticles comprise calcium based nanoparticles. 8 . The composition of claim 7 , wherein the inorganic nanoparticles comprise hydroxyapatite nanoparticles. 9 . The composition of claim 1 , further comprising at least one bioactive agent. 10 . The composition of claim 1 , further comprising a plurality of cells dispersed on and/or within the hydrogel. 11 . The composition of claim 10 , wherein the cells comprise progenitor cells, undifferentiated cells and/or differentiated cells. 12 . The composition of claim 11 , wherein the cells include mesenchymal stem cells. 13 . A composition comprising: an elastomeric nanocomposite hybrid hydrogel that includes first natural polymer macromers covalently crosslinked with second natural polymer macromers and the first natural polymer macromers are ionically crosslinked with a plurality of inorganic nanoparticles, wherein the plurality of inorganic nanoparticles ionically form reversible physical crosslinks with carboxylic groups of the first natural polymer macromers; the elastomeric nanocomposite hybrid hydrogel being cytocompatible, and, upon degradation, produce substantially non-toxic products, and wherein the elasticity of the elastomeric nanocomposite hybrid hydrogel is substantially maintained during degradation; and wherein the first natural polymer macromers are acrylated and/or methacrylated polysaccharides, which are optionally oxidized; the second natural polymer macromers are different from the first natural polymer macromers and include an acrylate group and/or methacrylate group; and wherein the acrylate and/or methacrylate groups of the first natural polymer macromers react with the acrylate and/or methacrylate groups of the second natural polymer macromers to form the covalent crosslinks. 14 . The composition of claim 13 , wherein the first natural polymer macromers comprise acrylated and/or methacrylated alginates, which are optionally oxidized, and the second natural polymer macromers comprise acrylated and/or methacrylated gelatin and wherein methacrylate and/or acrylate groups of optionally oxidized acrylated and/or methacrylated alginates react with methacrylate and/or acrylate groups of the acrylated and/or methacrylated gelatin to form the covalent crosslinks. 15 . The composition of claim 13 , wherein the inorganic nanoparticles comprise calcium based nanoparticles. 16 . The composition of claim 15 , wherein the inorganic nanoparticles comprise hydroxyapatite nanoparticles. 17 . The composition of claim 13 , further comprising at least one bioactive agent. 18 . The composition of claim 13 , further comprising a plurality of cells dispersed on and/or within the hydrogel.
Assignees
Inventors
Classifications
Gelatin · CPC title
derived from leather or skin {, e.g. gelatin} · CPC title
derived from horn, hoofs, hair, skin or leather · CPC title
Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title
Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces · CPC title
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Frequently asked questions
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- What does patent US12503559B2 cover?
- An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products.
- Who is the assignee on this patent?
- Univ Case Western Reserve
- What technology area does this patent fall under?
- Primary CPC classification C08L5/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 23 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).