Clot retrieval system for removing occlusive clot from a blood vessel

Patent metadata

Field	Value
Publication number	US-12502189-B2
Application number	US-202418643243-A
Country	US
Kind code	B2
Filing date	Apr 23, 2024
Priority date	Nov 26, 2014
Publication date	Dec 23, 2025
Grant date	Dec 23, 2025

Abstract

A clot removal device for removing clot from a body vessel comprising an expandable structure and an elongate member. The elongate member can have a proximal end and a distal end, the elongate member being connected to the expandable structure at its distal end. The expandable structure can have a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration. At least a portion of the expandable structure can be configured to engage clot in the expanded deployed configuration and to pinch clot on movement from the deployed configuration to the clot pinching configuration.

First claim

The invention claimed is:

1 . A clot removal device for removing a clot from a body vessel, comprising:
an expandable structure comprising a network of interconnected struts configured to engage with the clot and comprising a constrained delivery configuration, an expanded clot engaging deployed configuration, the network of interconnected struts being configured in the expanded clot engaging deployed configuration so at least a portion of the network interpenetrates the clot, the expandable structure comprising:
a distal section comprising an open distal end; and
a non-cylindrical proximal pinch section proximal of the distal section and comprising a diameter less than a diameter of the distal section, the proximal pinch section configured to pinch the clot on movement from the expanded clot engaging deployed configuration to the at least partially constrained clot pinching configuration,
the proximal pinch section being further configured such that when the network of interconnected struts is collapsed while in a state of interpenetration with the clot that at least a portion of the proximal pinch section pinches at least a portion of the clot; and an elongate member comprising a proximal end and a distal end connected to the proximal pinch section;
at least a first cell and at least one second cell formed by the network of interconnected struts, each comprising a collapsed delivery configuration; and
a distal fragment protector located at least partially within the distal section;
a clot engaging element configured to exert an outward radial force when deployed within the blood vessel having an inner diameter which is lower than that of the expanded deployed configuration, the clot engaging element being configured to exert an outward radial force varying in a generally sinusoidal pattern along a length of the clot engaging element; and a deployed expanded configuration with each cell further comprising an orifice, the orifice of at least some of the cells being configured to allow at least a portion of the clot to interpenetrate the structure, the expandable structure being configured to interpenetrate the clot defined by an extrusion of at least a portion of the clot through at least one of the first cells.

2 . The device of claim 1 , the distal section further comprising a distal barrel section flared outwardly to form a barrel shape with the open distal end, and
wherein the network of interconnected struts comprises at least a plurality of proximally facing struts and a plurality of distally facing struts,
a length of at least some of the proximally facing struts being larger than a length of at least some of the distally facing struts thereby varying an outward radial force of the device in the expanded clot engaging deployed configuration.

3 . The device of claim 2 , wherein the distal barrel section comprises distal radiopaque markers attached to distal most ends of at least two of the interconnected struts that form the distal barrel section.

4 . The device of claim 2 , further comprising:
a plurality of radiopaque markers positioned at a transition between the proximal pinch section and the distal barrel section.

5 . The device of claim 1 , wherein the proximal pinch section comprises a spiral form comprising a spiral pitch ranging between approximately 10-25 mm.

6 . The device of claim 1 , further comprising a longitudinal axis extended through the distal section, the proximal pinch section extending around the longitudinal axis in a spiral.

7 . The device of claim 1 , wherein the elongate member is configured to retract the network with the network both interpenetrating the clot and at least a portion of the network pinching on at least a portion of the clot.

8 . The device of claim 1 , wherein the network of interconnected struts extends between crowns and are configured to pinch clot located in at least one of the first cells as the device is moved from the expanded deployed configuration to the at least partially constrained clot pinching configuration, wherein each of the cells has a proximally facing crown and a distally facing crown and wherein the proximally facing crown has a diameter which is larger than a diameter of the distally facing crown.

9 . The device of claim 1 , wherein the generally sinusoidal pattern comprises a wave pattern comprising an amplitude that decreases along a length of the clot engaging element, the amplitude being higher at a proximal end and lower at a distal end of the clot engaging element.

10 . The device of claim 9 , the clot engaging element further comprising a plurality of adjacent segments configured such that the outward radial force exerted by at least two adjacent segments differs from each other.

11 . The device of claim 1 , wherein at least some of the struts and/or crowns of the expandable structure are aligned with the generally sinusoidal pattern to enhance embedding of the clot.

12 . The device of claim 1 , wherein a size of a clot-receiving cell towards a proximal end of the expandable structure is smaller than a cell towards a distal end of the expandable structure.

13 . The device of claim 1 further comprising a proximal joint between the elongate member and the expandable structure, the proximal joint comprising a step at the distal end of the elongate member.

14 . The device of claim 13 , wherein the proximal joint comprises a locking collar for engagement with the elongate member and the proximal end of the expandable structure.

15 . The device of claim 1 , wherein the distal end of the expandable structure comprises a recess configured for engagement with a step at the distal end of the elongate member.

16 . The device of claim 1 , wherein the distal end of the expandable structure comprises a slot configured for engagement with a step at the distal end of the elongate member.

17 . The device of claim 1 , wherein a distal end of the distal fragment protector is proximal of the open distal end of the distal section.

18 . The device of claim 1 , wherein the distal fragment protector comprises a closed distal end.

19 . The device of claim 18 , wherein the distal fragment protector comprises a net.

20 . A clot removal device for removing a clot from a body vessel, comprising:
an expandable structure comprising a network of interconnected struts configured to engage with the clot and comprising a constrained delivery configuration, an expanded clot engaging deployed configuration, the network of interconnected struts being configured in the expanded clot engaging deployed configuration so at least a portion of the network interpenetrates the clot, the expandable structure comprising:
a distal section comprising an open distal end; and
a non-cylindrical proximal pinch section proximal of the distal section and comprising a diameter less than a diameter of the distal section, the proximal pinch section configured to pinch the clot on movement from the expanded clot engaging deployed configuration to the at least partially constrained clot pinching configuration,
the proximal pinch section being further configured such that when the network of interconnected struts is collapsed while in a state of interpenetration with the clot that at least a portion of the proximal pinch section pinches at least a portion of the clot; and an elongate member comprising a proximal end and a distal end connected to the proximal pinch section; and
at least a first cell and at least one second cell formed by the networ

Assignees

• Neuravi Ltd

Inventors

• Casey Brendan
• Vale David
• Holian Maeve
• Hardiman David
• O'Connor Grainne

Classifications

• A61B2017/2215

  having an open distal end · CPC title

• A61B2017/2212

  having a closed distal end, e.g. a loop · CPC title

• A61B2017/22034

  for gripping the obstruction or the tissue part from inside · CPC title

• A61B2017/00778

  Operations on blood vessels (A61B2017/22097, A61B2017/320741 take precedence) · CPC title

• A61B2017/00526

  Methods of manufacturing · CPC title