Recombinant microorganisms and methods for producing cannabinoids and cannabinoid derivatives
US-10563211-B2 · Feb 18, 2020 · US
Biosynthesis of cannabinoids from cannabigerolic acid using novel cannabinoid synthases
US12497600B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12497600-B2 |
| Application number | US-202017767764-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 12, 2020 |
| Priority date | Oct 11, 2019 |
| Publication date | Dec 16, 2025 |
| Grant date | Dec 16, 2025 |
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- Title
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Abstract
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A method for producing a cannabinoid by contacting cannabigerolic acid with a cannabinoid synthase orthologue. The cannabinoid synthase orthologue is from an organism other than Cannabis sativa . Also disclosed is a recombinant cell of Saccharomyces cerevisiae or Pichia pastoris that includes in its genome a nucleic acid encoding the above cannabinoid synthase orthologue. The cannabinoid synthase orthologue is expressed in the recombinant cell in an active form.
First claim
Opening claim text (preview).
What is claimed is: 1 . A method for producing one or more cannabinoids, the method comprising contacting cannabigerolic acid (CBGA) with a cannabinoid synthase orthologue, wherein the orthologue includes an amino acid sequence selected from the group consisting of SEQ ID NOs: 16, 23, 47, 57, 87, 107 and 117 and wherein the cannabinoids produced have a molecular weight of 358.5 g/mol, 374.5 g/mol, or 330.5 g/mol. 2 . The method of claim 1 , wherein the cannabinoids produced include cannabielsoic acid and cannabielsoin. 3 . The method of claim 1 , wherein the cannabinoid synthase orthologue is a recombinant enzyme produced in Saccharomyces cerevisiae, Yarrowia lipolytica, Kluyveromyces marxianus , or Pichia pastoris.
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Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid · CPC title
containing a six-membered hetero ring, e.g. fluorescein · CPC title
- C12P17/04Primary
containing a five-membered hetero ring, e.g. griseofulvin {, vitamin C} · CPC title
for yeasts other than Saccharomyces · CPC title
Saccharomyces cerevisiae · CPC title
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- What does patent US12497600B2 cover?
- A method for producing a cannabinoid by contacting cannabigerolic acid with a cannabinoid synthase orthologue. The cannabinoid synthase orthologue is from an organism other than Cannabis sativa . Also disclosed is a recombinant cell of Saccharomyces cerevisiae or Pichia pastoris that includes in its genome a nucleic acid encoding the above cannabinoid synthase orthologue. The cannabinoid s…
- Who is the assignee on this patent?
- Nat Univ Singapore
- What technology area does this patent fall under?
- Primary CPC classification C12P17/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Dec 16 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 2 related publications on this page (citations in our corpus or others sharing the same primary CPC).