Fiber bundle, method for producing same, and purification column

Patent metadata

Field	Value
Publication number	US-12496387-B2
Application number	US-202017765660-A
Country	US
Kind code	B2
Filing date	Oct 7, 2020
Priority date	Oct 8, 2019
Publication date	Dec 16, 2025
Grant date	Dec 16, 2025

Abstract

An object of the present invention is to provide a purification column which is a small purification column in which a volume of a liquid to be treated is reduced in order to reduce the amount of blood to be taken out and which realizes a low pressure loss and has high adsorption performance. The present invention provides a fiber bundle including a plurality of porous fibers that satisfies the following requirements (A) to (E):
(A) the porous fiber has a non-hollow shape, (B) an arithmetic average roughness (dry Ra value) of a surface of the porous fiber in a dry state is 11 nm or more and 30 nm or less, (C) an arithmetic average roughness (wet Ra value) of a surface of the porous fiber in a wet state is 12 nm or more and 40 nm or less, (D) a value represented by wet Ra/dry Ra is 1.05 or more, and (E) a linear rate of the fiber bundle represented by (length of fiber bundle)/(length of one porous fiber) is 0.97 or more and 1.00 or less.

First claim

The invention claimed is:

1 . A fiber bundle comprising a plurality of porous fibers that satisfies the following requirements (A) to (E):
(A) the porous fiber has a non-hollow shape, (B) an arithmetic average roughness (dry Ra value) of a surface of the porous fiber in a dry state is 11 nm or more and 30 nm or less, (C) an arithmetic average roughness (wet Ra value) of a surface of the porous fiber in a wet state is 12 nm or more and 40 nm or less, (D) a value represented by wet Ra/dry Ra is 1.05 or more, and (E) a linear rate of the fiber bundle represented by (length of fiber bundle)/(length of one porous fiber) is 0.97 or more and 1.00 or less.

2 . The fiber bundle according to claim 1 , wherein when a diameter of an inscribed circle is defined as Di and a diameter of a circumscribed circle is defined as Do in a transverse cross-section of the porous fiber, a modification degree of the transverse cross-section of the porous fiber represented by Do/Di is 1.3 or more and 8.5 or less.

3 . The fiber bundle according to claim 1 , wherein the porous fiber has an average pore radius of 0.8 nm or more and 90 nm or less.

4 . The fiber bundle according to claim 1 , wherein the porous fiber has a homogeneous porous structure in a transverse cross-sectional direction.

5 . The fiber bundle according to claim 1 ,
wherein the porous fiber has a surface opening ratio of 0.1% or more and 30% or less.

6 . The fiber bundle according to claim 1 , wherein an equivalent circle diameter of a transverse cross-section of the porous fiber is 10 μm or more and 1,000 μm or less.

7 . The fiber bundle according to claim 1 ,
wherein an adsorption amount of IgG of the porous fiber is 13 mg/cm 3 or less.

8 . The fiber bundle according to claim 1 , wherein an adsorption amount of a tumor necrosis factor α (TNFα) of the porous fiber is 15 μg/cm 3 or more.

9 . A purification column, wherein
the fiber bundle according to claim 1 is housed substantially in parallel to a longitudinal direction of a tubular case, and the purification column comprises headers, having an inlet port and an outlet port for a liquid to be treated, are attached to both ends of the tubular case, respectively.

Assignees

• Toray Industries

Inventors

• Osuka Tomoaki
• Fujieda Hiroaki
• Ueno Yoshiyuki
• Sakaguchi Hirokazu

Classifications

• B01J20/28023 Primary

  Fibres or filaments (fibres or filaments in the form of membranes B01J20/28038; B01J20/28007 takes precedence) · CPC title

• A61M1/3679 Primary

  by absorption (A61M1/3675 takes precedence) · CPC title

• A61M1/3606 Primary

  Arrangements for blood-volume reduction of extra-corporeal circuits · CPC title

• B01D15/206

  Packing or coating · CPC title

• B01D15/22 Primary

  relating to the construction of the column · CPC title