Analyte sensor electrode arrangements

Patent metadata

Field	Value
Publication number	US-12495996-B2
Application number	US-202318126220-A
Country	US
Kind code	B2
Filing date	Mar 24, 2023
Priority date	Jul 16, 2019
Publication date	Dec 16, 2025
Grant date	Dec 16, 2025

Abstract

Various examples are directed to a glucose sensor comprising a working electrode to support an oxidation reaction and a reference electrode to support a redox reaction. The reference electrode may comprise silver and silver chloride. The Glucose sensor may also comprise an anti-mineralization agent positioned at the reference electrode to reduce formation of calcium carbonate at the reference electrode.

First claim

What is claimed is:

1 . A glucose sensor comprising:
a working electrode; and a reference electrode, the reference electrode comprising:
silver particles,
silver chloride particles,
an anti-mineralization agent,
platinum particles, and
a binder material, wherein the silver particles, the silver chloride particles, the platinum particles, and the anti-mineralization agent are incorporated into the binder material.

2 . The glucose sensor of claim 1 , further comprising:
a mediator material at the reference electrode.

3 . The glucose sensor of claim 2 , wherein the mediator material is configured to catalyze oxygen redox at the reference electrode at least in part with the silver.

4 . The glucose sensor of claim 2 , wherein the mediator material comprises a quinone derivative.

5 . The glucose sensor of claim 4 , wherein the quinone derivative selected from the group consisting of biquinone, 1-napthaquinone, 4-napthaquinone.

6 . The glucose sensor of claim 2 , wherein the mediator material is selected from the group consisting of a transition metal porphyrins, a nitroxyl species, and a hydrazine.

7 . The glucose sensor of claim 1 , wherein the anti-mineralization agent is selected from the group consisting of a polyacrylate and a carboxylate-containing polymer.

8 . The glucose sensor of claim 1 , wherein the anti-mineralization agent comprises a polyacrylate.

9 . The glucose sensor of claim 1 , wherein the anti-mineralization agent comprises a carboxylate-containing polymer.

10 . The glucose sensor of claim 9 , wherein the carboxylate-containing polymer is selected from the group consisting of a poly(maleate), a polysulfonate, and a polyphosphonate.

11 . The glucose sensor of claim 1 , further comprising:
a membrane system comprising an anti-mineralization layer positioned at least in part over the reference electrode, the anti-mineralization layer comprising at least a portion of the anti-mineralization agent.

12 . The glucose sensor of claim 11 , wherein the membrane system includes an interference domain positioned at least in part over the working electrode, the interference domain comprising a first interference agent and at least a portion of the anti-mineralization agent.

13 . The glucose sensor of claim 1 , further comprising a membrane system, the membrane system comprising:
a resistance domain positioned at least in part over the reference electrode; and a hydrophilic domain positioned at least in part over the reference electrode.

14 . The glucose sensor of claim 1 , wherein the silver comprises:
microscale silver particles; and nanoscale silver particles.

15 . The glucose sensor of claim 14 , wherein the microscale silver particles have an average width of between about 1 micron and about 10 microns, and the nanoscale silver particles have an average size that is less than 100 nanometers.

16 . The glucose sensor of claim 14 , wherein the nanoscale silver particles make up between about 0.1% and about 10% of the silver by volume.

17 . The glucose sensor of claim 1 , wherein the reference electrode is positioned over an insulating material.

18 . The glucose sensor of claim 1 , further comprising: a flexible layer, wherein the flexible layer is positioned under the reference electrode.

19 . The glucose sensor of claim 1 , wherein the binder material is not electrically conductive.

20 . The glucose sensor of claim 1 , wherein the binder comprises a thermoplastic polymer.

21 . The glucose sensor of claim 1 , wherein the binder comprises a polyurethane.

Assignees

• Dexcom Inc

Inventors

• Bohm Sebastian
• Lan Wenjie
• Porter Thomas Robert
• Rong Daiting
• Halac Jason

Classifications

• G01N27/301

  Reference electrodes · CPC title

• G01N27/3271

  Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood (amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001) · CPC title

• A61B2562/125

  characterised by the manufacture of electrodes · CPC title

• C09D133/08

  Homopolymers or copolymers of acrylic acid esters · CPC title

• A61B5/1468

  using chemical or electrochemical methods, e.g. by polarographic means · CPC title