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Seedless synthesis of anisotropic gold nanoflowers with cellular control and drug delivery applications
US12485484B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12485484-B2 |
| Application number | US-202318197195-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 15, 2023 |
| Priority date | May 17, 2022 |
| Publication date | Dec 2, 2025 |
| Grant date | Dec 2, 2025 |
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Abstract
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A new seedless synthesis of anisotropic nanoscale gold nanoflower (AuNF) particles uses bidentate thiolate ligands to protect the nanoparticle surface and a combination of reagents (for example, ligand, ascorbic acid, and hydroxide) to synthesis AuNF with controlled size and anisotropic properties. Compared to prior art gold nanospheres, AuNF produced approximately a 15-fold improvement in a drug delivery assay.
First claim
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What is claimed is: 1 . A method of synthesizing anisotropic gold nanoparticles, the method comprising: providing aurate ions, a ligand comprising thioctic acid, a reducing agent, and hydroxide and allowing them to react in an aqueous phase, thereby obtaining anisotropic gold nanoparticles having diameters in a range of 15-500 nm. 2 . The method of claim 1 , wherein the reducing agent is ascorbic acid. 3 . The method of claim 1 , wherein the ligand is selected from the group consisting of thioctic acid-NH 2 (TA-NH 2 ), TA-nitrilotriacetic acid (TA-NTA), TA-polyethylene glycol-COOH (TA-PEG-COOH), and TA-polyethylene glycol-NH 2 (TA-PEG-NH 2 ). 4 . The method of claim 1 , wherein, by controlling reaction conditions, one can obtain nanoparticles of greater or smaller size in said range of 15-500 nm in diameter. 5 . A method of synthesizing anisotropic gold nanoparticles, the method comprising: providing aurate ions, a ligand comprising thioctic acid, ascorbic acid, and hydroxide and allowing them to react in an aqueous phase, thereby obtaining anisotropic gold nanoparticles having diameters in a range of 15-500 nm, wherein the ligand is selected from the group consisting of thioctic acid-NH 2 (TA-NH 2 ), TA-nitrilotriacetic acid (TA-NTA), TA-polyethylene glycol-COOH (TA-PEG-COOH), and TA-polyethylene glycol-NH 2 (TA-PEG-NH 2 ).
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Classifications
Silver or gold · CPC title
Particle size above 300 nm up to 1 micrometer · CPC title
Particle size between 1 and 100 nm · CPC title
Reduction reaction in an Ionic Liquid [IL] · CPC title
Particle size above 100 nm up to 300 nm · CPC title
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- What does patent US12485484B2 cover?
- A new seedless synthesis of anisotropic nanoscale gold nanoflower (AuNF) particles uses bidentate thiolate ligands to protect the nanoparticle surface and a combination of reagents (for example, ligand, ascorbic acid, and hydroxide) to synthesis AuNF with controlled size and anisotropic properties. Compared to prior art gold nanospheres, AuNF produced approximately a 15-fold improvement in a dr…
- Who is the assignee on this patent?
- Us Gov Sec Navy
- What technology area does this patent fall under?
- Primary CPC classification B22F9/24. Mapped technology areas include Operations & Transport.
- When was this patent published?
- Publication date Tue Dec 02 2025 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 3 related publications on this page (citations in our corpus or others sharing the same primary CPC).