Multifocal contact lens displaying improved vision attributes

Patent metadata

Field	Value
Publication number	US-12481173-B2
Application number	US-202218060139-A
Country	US
Kind code	B2
Filing date	Nov 30, 2022
Priority date	Aug 30, 2019
Publication date	Nov 25, 2025
Grant date	Nov 25, 2025

Abstract

Described are multifocal contact lenses that contain high energy visible (HEV) light absorbing compounds and their use for improving one or more vision attributes.

First claim

We claim:

1 . A contact lens that is a free radical reaction product of a reactive mixture comprising:
one or more polymerizable compounds suitable for making the contact lens; a high energy visible (HEV) light absorbing compound; and a UV absorbing compound comprising a benzophenone, a benzotriazole, a triazine, a substituted acrylonitrile, a salicyclic acid derivative, a benzoic acid derivative, a cinnamic acid derivative, a chalcone derivative, a dypnone derivative, a crotonic acid derivative, or mixtures thereof,
wherein the contact lens is a multifocal contact lens, wherein the contact lens transmits from 0 percent to 70 percent of light across a wavelength range of 400 to 409 nm, and transmits 45 percent or less of light across a wavelength range of 280 to 399 nm.

2 . The contact lens of claim 1 that transmits at least 80 percent of light across a wavelength range of 450 to 800 nm.

3 . The contact lens of claim 1 that is photostable.

4 . The contact lens of claim 1 that is a multifocal toric contact lens.

5 . The contact lens of claim 1 wherein the high energy visible light absorbing compound is a static compound.

6 . The contact lens of claim 1 wherein the high energy visible light absorbing compound comprises a compound of formula I:

wherein:
m and n are independently 0, 1, 2, 3, or 4;
T is a bond, O, or NR;
Y is a linking group;
P g is a polymerizable group;
R at each occurrence is independently H, C 1 -C 6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or Y—P g ; and

R 1 and R 2 , when present, are independently at each occurrence C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, C 3 -C 7 cycloalkyl, aryl (preferably unsubstituted phenyl or phenyl substituted with alkyl or halo), halo, hydroxy, amino, NR 3 R 4 , or benzyl, wherein R 3 and R 4 are independently H or C 1 -C 6 alkyl, or two adjacent R 1 or R 2 groups, together with the carbon atoms to which they are attached, combine to form a cycloalkyl or aryl ring.

7 . The contact lens of claim 6 wherein m and n are each independently 0 or 1.

8 . The contact lens of claim 6 wherein Y at each occurrence is independently alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene, oxaalkylene, alkylene-amide-alkylene, alkylene-amine-alkylene, or combinations thereof.

9 . The contact lens of claim 6 wherein P g comprises styryl, vinyl carbonate, vinyl ether, vinyl carbamate, N-vinyl lactam, N-vinylamide, (meth)acrylate, or (meth)acrylamide.

10 . The contact lens of claim 1 wherein the polymerizable compound suitable for making the contact lens comprises a hydrophilic component, a silicone-containing component, or mixtures thereof.

11 . A method for improving a vision attribute in a presbyopic contact lens wearer, the method comprising: providing the presbyopic contact lens wearer with a contact lens according to claim 1 , wherein the vision attribute is selected from one or more of quality of vision, clarity of vision, glare reduction, reduction of squinting, and chromatic contrast.

12 . The method of claim 11 wherein improving a vision attribute comprises an improvement in the vision attribute as observed by a presbyopic contact lens wearer when compared to a multifocal contact lens that does not contain a HEV light absorbing compound.

13 . The contact lens of claim 1 , wherein the HEV light absorbing compound comprises: 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl acrylate; N-(2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl)methacrylamide; N-(2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl)acrylamide; 2-(2-cyano-N-methyl-2-(9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; 2-cyano-2-(9H-thioxanthen-9-ylidene)-N-(2-(N-vinylacetamido)ethyl)acetamide; 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetamido)-2-methylpropyl methacrylate; (E)-2-(2-cyano-2-(2,4-dichloro-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; (E)-2-(2-(2-chloro-9H-thioxanthen-9-ylidene)-2-cyanoacetamido)ethyl methacrylate; (E)-2-(2-cyano-2-(2-isopropyl-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; (E)-2-(2-cyano-2-(4-isopropyl-9H-thioxanthen-9-ylidene)acetamido)ethyl methacrylate; 2-(2-cyano-2-(9H-thioxanthen-9-ylidene)acetoxy)ethyl methacrylate; or mixtures thereof.

14 . A method for improving a vision attribute in a presbyopic contact lens wearer, the method comprising:
providing the presbyopic contact lens wearer with a multifocal contact lens that is a free radical reaction product of a reactive mixture comprising:
one or more polymerizable compounds suitable for making the contact lens; and
a high energy visible (HEV) light absorbing compound; and
a UV absorbing compound comprising a benzophenone, a benzotriazole, a triazine, a substituted acrylonitrile, a salicyclic acid derivative, a benzoic acid derivative, a cinnamic acid derivative, a chalcone derivative, a dypnone derivative, a crotonic acid derivative, or mixtures thereof,

wherein the vision attribute is selected from one or more of quality of vision, clarity of vision, glare reduction, reduction of squinting, and chromatic contrast, wherein the contact lens transmits from 0 percent to 70 percent of light across a wavelength range of 400 to 409 nm, and transmits 45 percent or less of light across a wavelength range of 280 to 399 nm.

Assignees

• Johnson & Johnson Vision Care

Inventors

• Mahadevan Shivkumar
• Wright Dawn D
• Clark Ronald J
• Karkkainen Thomas R
• Nankivil Derek

Classifications

• G02C7/049

  Contact lenses having special fitting or structural features achieved by special materials or material structures · CPC title

• G02C7/10

  Filters, e.g. for facilitating adaptation of the eyes to the dark; Sunglasses · CPC title

• C09B23/04

  one >CH- group, e.g. cyanines, isocyanines, pseudocyanines · CPC title

• C09B23/0058

  the substituent being CN · CPC title

• C09B62/44

  with the reactive group not directly attached to a heterocyclic ring · CPC title