Centrifugal separation and collection of red blood cells and plasma

Patent metadata

Field	Value
Publication number	US-12478712-B2
Application number	US-202318391085-A
Country	US
Kind code	B2
Filing date	Dec 20, 2023
Priority date	May 23, 2019
Publication date	Nov 25, 2025
Grant date	Nov 25, 2025

Abstract

Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.

First claim

The invention claimed is:

1 . A controller-implemented blood separation method for a blood separation system comprising a fluid flow circuit mounted to a blood separation device including a centrifugal separator and a spinning membrane separator drive unit, the method comprising:
controlling a pump system of the blood separation device to convey blood through the fluid flow circuit; controlling the centrifugal separator to separate red blood cells and plasma from at least a portion of the blood in the fluid flow circuit; controlling the pump system to collect at least a portion of the separated red blood cells; and controlling the pump system to collect at least a portion of the separated plasma, wherein the method further includes either
controlling the pump system to convey said at least portion of the separated plasma directly from the centrifugal separator to a plasma collection container of the fluid flow circuit,
controlling the pump system to convey said at least a portion of the separated plasma from the centrifugal separator through a spinning membrane separator of the fluid flow circuit associated to the spinning membrane separator drive unit to remove cellular blood components from said at least a portion of the separated plasma prior to collection of said at least a portion of the separated plasma, with at least a portion of the cellular blood components being retained within the spinning membrane separator, or
controlling the pump system to convey said at least a portion of the separated plasma from the centrifugal separator through a spinning membrane separator of the fluid flow circuit associated to the spinning membrane separator drive unit to remove cellular blood components from said at least a portion of the separated plasma prior to collection of said at least a portion of the separated plasma, with at least a portion of the cellular blood components being conveyed to a recipient.

2 . The method of claim 1 , wherein said controlling the centrifugal separator to separate red blood cells and plasma from said at least a portion of the blood in the fluid flow circuit includes controlling the pump system to convey at least a portion of the red blood cells into a return container.

3 . The method of claim 2 , further comprising controlling the pump system to convey at least a portion of the red blood cells in the return container out of the fluid flow circuit while controlling the centrifugal separator to separate red blood cells and plasma from blood.

4 . The method of claim 1 , wherein
said controlling the pump system to collect at least a portion of the separated red blood cells includes
controlling the pump system to mix said at least a portion of the separated red blood cells with an additive solution, and
controlling the pump system to convey the mixture of separated red blood cells and additive solution through a leukocyte removal filter, and
the additive solution is added to said at least a portion of the separated red blood cells at a rate configured to produce a mixture having a predetermined or preselected hematocrit.

5 . The method of claim 1 , wherein said controlling the pump system to convey blood through the fluid flow circuit includes controlling the pump system to convey a portion of the blood into an in-process container and another portion of the blood into the centrifugal separator.

6 . The method of claim 5 , further comprising
controlling the pump system to convey at least a portion of the blood in the in-process container into the centrifugal separator, controlling the centrifugal separator to separate red blood cells and plasma from said at least a portion of the blood from the in-process container, controlling the pump system to collect at least a portion of the plasma separated from the blood from the in-process container, and controlling the pump system to convey at least a portion of the red blood cells separated from the blood from the in-process container out of the fluid flow circuit.

7 . The method of claim 5 , further comprising
controlling the pump system to convey at least a portion of the blood in the in-process container into the centrifugal separator, controlling the centrifugal separator to separate red blood cells and plasma from said at least a portion of the blood from the in-process container, and controlling the pump system to collect at least a portion of the plasma separated from the blood from the in-process container and at least a portion of the red blood cells separated from the blood from the in-process container.

8 . The method of claim 1 , further comprising,
controlling the pump system to convey said at least a portion of the separated plasma into the spinning membrane separator drive unit, and controlling the spinning membrane separator drive unit to separate said at least a portion of the separated plasma into cellular blood components and substantially cell-free plasma.

9 . The method of claim 8 , further comprising controlling the pump system to convey the substantially cell-free plasma out of the spinning membrane separator drive unit without conveying the cellular blood components out of the spinning membrane separator drive unit.

10 . The method of claim 8 , further comprising
controlling the pump system to convey the substantially cell-free plasma out of the spinning membrane separator drive unit, and after conveying the substantially cell-free plasma out of the spinning membrane separator drive unit, controlling the pump system to convey the cellular blood components out of the spinning membrane separator drive unit.

Assignees

• Fenwal Inc

Inventors

• Kusters Benjamin E
• Min Kyungyoon

Classifications

• A61M1/36225

  with blood pumping means or components thereof · CPC title

• A61M1/362261

  at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil · CPC title

• A61M1/362265

  Details of valves · CPC title

• A61M1/36224

  with sensing means or components thereof · CPC title

• A61M1/362227

  the interface providing means for actuating on functional elements of the cassette, e.g. plungers · CPC title