Microcapsules and processes for their preparation

Patent metadata

Field	Value
Publication number	US-12478064-B2
Application number	US-201816766684-A
Country	US
Kind code	B2
Filing date	Nov 22, 2018
Priority date	Nov 23, 2017
Publication date	Nov 25, 2025
Grant date	Nov 25, 2025

Abstract

The present invention provides microcapsules encapsulating hydrophilic or hydrophobic active agents in an inorganic shell, processes for their preparation and compositions comprising them.

First claim

The invention claimed is:

1 . A process for the preparation of microcapsules encapsulating at least one active agent in a metal oxide shell comprising the steps of:
Preparing a non-hydrous emulsion comprising at least one polar phase, at least one non-polar phase, at least one active agent, at least one metal oxide precursor, at least one condensation precursor and at least one surface active agent; Subjecting said non-hydrous emulsion to at least one condition allowing the formation of a metal oxide shell encapsulating said at least one active agent;
thereby forming said microcapsules;
wherein said non-hydrous emulsion further comprises at least one catalyst.

2 . The process according to claim 1 , wherein said non hydrous emulsion is prepared by:
(i) mixing said at least one polar phase and said at least one non-polar phase, wherein said at least one non-polar phase comprises the at least one metal oxide precursor prior to said mixing; or (ii) mixing said at least one polar phase and said at least one non-polar phase, wherein said at least one polar phase comprises the at least one condensation precursor prior to said mixing; or (iii) mixing said at least one polar phase and said at least one non-polar phase, wherein said at least one metal oxide precursor is added after said mixing; or (iv) mixing said at least one polar phase and said at least one non-polar phase, wherein said at the least one condensation precursor is added after said mixing; or (v) mixing said at least one polar phase and said at least one non-polar phase, wherein said at least one non-polar phase comprises at least one surfactant prior to said mixing; or (vi) mixing said at least one polar phase and said at least one non-polar phase, wherein said at least one polar phase comprises at least one surfactant prior to said mixing; or (vii) mixing said at least one polar phase and said at least one non-polar phase, wherein said at least one non-polar phase comprises at least one active agent prior to said mixing; or (viii) mixing said at least one polar phase and said at least one non-polar phase, wherein said at least one polar phase comprises the at least one active agent prior to said mixing.

3 . The process according to claim 1 , wherein said at least one polar phase is selected from a hydrophobic polar phase or a hydrophilic polar phase.

4 . The process according to claim 1 , wherein said at least one non-polar phase is selected from a hydrophobic non-polar phase or a hydrophilic non-polar phase.

5 . The process according to claim 1 , wherein said at least one condition allowing the formation of a metal oxide shell encapsulating the at least one active agent comprises homogenizing, stirring, aging, temperature, ratio between the polar and non-polar phases, surfactant concentration, concentration of condensation precursor.

6 . The process according to claim 1 , wherein said at least one active agent is dissolved in at least one of said polar phase and said non-polar phase.

7 . The process according to claim 1 , wherein said at least one active agent is dispersed in at least one of said polar phase and said non-polar phase.

Assignees

• Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd

Inventors

• Abu-Reziq Raed
• Batarseh Charlie
• Zarour Ahmad
• Schnell Yafit
• Zoabi Amani
• Natour Suzana
• Omar Suheir
• Weiss Esti

Classifications

• B01J35/23

  in a colloidal state · CPC title

• B01J35/45

  Nanoparticles · CPC title

• B01J2531/824

  Palladium · CPC title

• B01J2231/646

  of aromatic or heteroaromatic rings · CPC title

• B01J37/0072

  Preparation of particles, e.g. dispersion of droplets in an oil bath · CPC title