Polymer-coated substrate and medical analysis device

Patent metadata

Field	Value
Publication number	US-12473455-B2
Application number	US-202318116599-A
Country	US
Kind code	B2
Filing date	Mar 2, 2023
Priority date	Mar 31, 2022
Publication date	Nov 18, 2025
Grant date	Nov 18, 2025

Abstract

Provided are a polymer-coated substrate in which a polymer layer formed on the surface of a substrate is stable for a long period of time even in a liquid environment, and a medical analysis device including the polymer-coated substrate. Included is a polymer-coated substrate which includes a substrate, a silane compound layer formed on a surface of the substrate, and a polymer layer formed on the silane compound layer.

First claim

The invention claimed is:

1 . A polymer-coated substrate, comprising:
a substrate; a silane compound layer formed on a surface of the substrate; and a polymer layer formed on the silane compound layer, wherein the polymer layer is formed of:
(i) at least one selected from the group consisting of polymers represented by the following formula (I):

where R 51 represents a hydrogen atom or a methyl group; R 52 represents an alkyl group; p represents 1 to 8; m represents 1 to 5; and n represents the number of repetitions and n is 15 to 1500, or
(ii) a copolymer of at least one hydrophilic monomer selected from the group consisting of compounds represented by the following formula (II) with an additional monomer:

wherein R 51 represents a hydrogen atom or a methyl group; R 52 represents an alkyl group; p represents 1 to 8; and m represents 1 to 5.

2 . The polymer-coated substrate according to claim 1 , wherein the polymer layer has a thickness of 10 to 1000 nm.

3 . The polymer-coated substrate according to claim 1 , wherein the polymer layer has a scaffold protein adsorbed onto a surface thereof.

4 . The polymer-coated substrate according to claim 3 , wherein the scaffold protein is fibronectin.

5 . The polymer-coated substrate according to claim 1 , wherein the silane compound is an alkoxysilane.

6 . A medical analysis device, comprising the polymer-coated substrate according to claim 1 .

Assignees

• Sumitomo Rubber Ind

Inventors

• Minagawa Yasuhisa
• Takii Mitsuko

Classifications

• G01N33/575

  for cancer · CPC title

• C09D133/08

  Homopolymers or copolymers of acrylic acid esters · CPC title

• C09D4/00

  Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond {; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16} · CPC title

• C09D183/02

  Polysilicates · CPC title

• C08F120/28

  containing no aromatic rings in the alcohol moiety · CPC title